Location of monoclonal peak as a tool in checking specimen integrity
Objectives: Serum protein electrophoresis is a commonly used test in the diagnosis and follow-up of patients with monoclonal gammopathies. The practice of documenting the location of the peak may serve as delta check flags in SPEP samples. Methods: We report on the inconsistent finding on two tests...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-08-01
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| Series: | Practical Laboratory Medicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235255171630052X |
| _version_ | 1819085390563246080 |
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| author | Shikhar G. Vyas Gurmukh Singh |
| author_facet | Shikhar G. Vyas Gurmukh Singh |
| author_sort | Shikhar G. Vyas |
| collection | DOAJ |
| description | Objectives: Serum protein electrophoresis is a commonly used test in the diagnosis and follow-up of patients with monoclonal gammopathies. The practice of documenting the location of the peak may serve as delta check flags in SPEP samples. Methods: We report on the inconsistent finding on two tests performed about three months apart. The inconsistency was discovered due to recognition of the change in the location of the monoclonal immunoglobulin on protein electrophoresis. Results: Repeat testing with a third specimen revealed that the first test was run on a wrong specimen. Conclusion: Recording the location of the monoclonal spike is recommended to serve as an additional “delta” check. Keywords: Monoclonal gammopathies, M-peak location, Delta check, Specimen Mislabeling |
| first_indexed | 2024-12-21T21:03:36Z |
| format | Article |
| id | doaj.art-f07640999f57420bac348b2198d6f892 |
| institution | Directory Open Access Journal |
| issn | 2352-5517 |
| language | English |
| last_indexed | 2024-12-21T21:03:36Z |
| publishDate | 2017-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Practical Laboratory Medicine |
| spelling | doaj.art-f07640999f57420bac348b2198d6f8922022-12-21T18:50:23ZengElsevierPractical Laboratory Medicine2352-55172017-08-0184951Location of monoclonal peak as a tool in checking specimen integrityShikhar G. Vyas0Gurmukh Singh1Resident in Pathology, Medical College of Georgia at Augusta University, 1120, 15th Street BI 2008A, Augusta, GA 30912, USA; Corresponding author.Shepeard Chair in Clinical Pathology, Department of Pathology, BI 2008A, Medical College of Georgia at Augusta University, 1120, 15th Street BI 2008A, Augusta, GA 30912, USAObjectives: Serum protein electrophoresis is a commonly used test in the diagnosis and follow-up of patients with monoclonal gammopathies. The practice of documenting the location of the peak may serve as delta check flags in SPEP samples. Methods: We report on the inconsistent finding on two tests performed about three months apart. The inconsistency was discovered due to recognition of the change in the location of the monoclonal immunoglobulin on protein electrophoresis. Results: Repeat testing with a third specimen revealed that the first test was run on a wrong specimen. Conclusion: Recording the location of the monoclonal spike is recommended to serve as an additional “delta” check. Keywords: Monoclonal gammopathies, M-peak location, Delta check, Specimen Mislabelinghttp://www.sciencedirect.com/science/article/pii/S235255171630052X |
| spellingShingle | Shikhar G. Vyas Gurmukh Singh Location of monoclonal peak as a tool in checking specimen integrity Practical Laboratory Medicine |
| title | Location of monoclonal peak as a tool in checking specimen integrity |
| title_full | Location of monoclonal peak as a tool in checking specimen integrity |
| title_fullStr | Location of monoclonal peak as a tool in checking specimen integrity |
| title_full_unstemmed | Location of monoclonal peak as a tool in checking specimen integrity |
| title_short | Location of monoclonal peak as a tool in checking specimen integrity |
| title_sort | location of monoclonal peak as a tool in checking specimen integrity |
| url | http://www.sciencedirect.com/science/article/pii/S235255171630052X |
| work_keys_str_mv | AT shikhargvyas locationofmonoclonalpeakasatoolincheckingspecimenintegrity AT gurmukhsingh locationofmonoclonalpeakasatoolincheckingspecimenintegrity |