Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications
Gelatin, a denatured form of collagen, is an attractive biomaterial for biotechnology. In particular, gelatin particles have been noted due to their attractive properties as drug carriers. The drug release from gelatin particles can be easily controlled by the crosslinking degree of gelatin molecule...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/22/6795 |
| _version_ | 1797509189940019200 |
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| author | Teruki Nii |
| author_facet | Teruki Nii |
| author_sort | Teruki Nii |
| collection | DOAJ |
| description | Gelatin, a denatured form of collagen, is an attractive biomaterial for biotechnology. In particular, gelatin particles have been noted due to their attractive properties as drug carriers. The drug release from gelatin particles can be easily controlled by the crosslinking degree of gelatin molecule, responding to the purpose of the research. The gelatin particles capable of drug release are effective in wound healing, drug screening models. For example, a sustained release of growth factors for tissue regeneration at the injured sites can heal a wound. In the case of the drug screening model, a tissue-like model composed of cells with high activity by the sustained release of drug or growth factor provides reliable results of drug effects. Gelatin particles are effective in drug delivery and the culture of spheroids or cell sheets because the particles prevent hypoxia-derived cell death. This review introduces recent research on gelatin microparticles-based strategies for regenerative therapy and drug screening models. |
| first_indexed | 2024-03-10T05:15:18Z |
| format | Article |
| id | doaj.art-f07697e925264decb94817d39280b785 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T05:15:18Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f07697e925264decb94817d39280b7852023-11-23T00:33:50ZengMDPI AGMolecules1420-30492021-11-012622679510.3390/molecules26226795Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening ApplicationsTeruki Nii0Graduate School of Systems Life Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, JapanGelatin, a denatured form of collagen, is an attractive biomaterial for biotechnology. In particular, gelatin particles have been noted due to their attractive properties as drug carriers. The drug release from gelatin particles can be easily controlled by the crosslinking degree of gelatin molecule, responding to the purpose of the research. The gelatin particles capable of drug release are effective in wound healing, drug screening models. For example, a sustained release of growth factors for tissue regeneration at the injured sites can heal a wound. In the case of the drug screening model, a tissue-like model composed of cells with high activity by the sustained release of drug or growth factor provides reliable results of drug effects. Gelatin particles are effective in drug delivery and the culture of spheroids or cell sheets because the particles prevent hypoxia-derived cell death. This review introduces recent research on gelatin microparticles-based strategies for regenerative therapy and drug screening models.https://www.mdpi.com/1420-3049/26/22/6795biotechnologydrug deliverydrug research modelgelatinregenerative medicine |
| spellingShingle | Teruki Nii Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications Molecules biotechnology drug delivery drug research model gelatin regenerative medicine |
| title | Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications |
| title_full | Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications |
| title_fullStr | Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications |
| title_full_unstemmed | Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications |
| title_short | Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications |
| title_sort | strategies using gelatin microparticles for regenerative therapy and drug screening applications |
| topic | biotechnology drug delivery drug research model gelatin regenerative medicine |
| url | https://www.mdpi.com/1420-3049/26/22/6795 |
| work_keys_str_mv | AT terukinii strategiesusinggelatinmicroparticlesforregenerativetherapyanddrugscreeningapplications |