The Effects of Red Grape Juice and Exercise on Parkinson's Disease in Male Rats
Background: Neural degeneration is induced by production of oxidant agents in neural pools. Red grape juice has antioxidant agents. Exercise can be able to protect dopaminergic neurons of brain. Therefore, it seems that red grape juice and exercise can prevent neural impairment in neurodegenerative...
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Isfahan University of Medical Sciences
2012-01-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/444 |
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| author | Fatemeh Eshraghi Jazi Hojjatollah Alaei Hamid Azizi Malekabadi Ali Asghar Pilehvarian Mahin Gharavi Naeini Mohammad Saleh Ahmadi Emad Shah-Mansouri Zahra Ciahmard |
| author_facet | Fatemeh Eshraghi Jazi Hojjatollah Alaei Hamid Azizi Malekabadi Ali Asghar Pilehvarian Mahin Gharavi Naeini Mohammad Saleh Ahmadi Emad Shah-Mansouri Zahra Ciahmard |
| author_sort | Fatemeh Eshraghi Jazi |
| collection | DOAJ |
| description | Background: Neural degeneration is induced by production of oxidant agents in neural pools. Red grape juice has antioxidant agents. Exercise can be able to protect dopaminergic neurons of brain. Therefore, it seems that red grape juice and exercise can prevent neural impairment in neurodegenerative diseases. In this study, neuroprotective effects of red grape juice and exercise on Parkinson's disease in male rats were compared.
Methods: In order to create Parkinson's in rats, they were received unilateral infusion of
6-hydroxydopamine (6-OHDA) into substantia nigra pars compacta by a stereotaxic apparatus. Two weeks after surgery, the rats were treated with red grape juice and exercise for 1 month. In order to estimate the extent of lesion, they received intraperitoneal apomorphine. The number of rotations until 1 hour after injection was calculated as the main parameter for evaluation of Parkinson's disease.
Findings: Our results showed that red grape juice decreased the signs of Parkinson's disease compared to other groups. In addition, groups with Parkinson's disease which did not receive red grape juice presented the highest numbers of rotations. The results also indicated that injection of 6-OHDA induced Parkinson's disease whose signs occurred as rotations resulted by the administration of dopamine agonist agents. These effects were reduced using red grape juice. Exercise also reduced rotations in treated groups with Parkinson's disease. Moreover, red grape juice reduced rotations in Parkinson's disease rats significantly more than exercise.
Conclusion: The main place of release of dopamine in the brain is substantia nigra nucleus. This nucleus has an important role in controlling and coordination of voluntary activities of skeletal muscles. Injection of 6-OHDA into this area decreased the release of dopamine and finally induced Parkinson's disease. Using red grape juice probably treats this disease via compensation of dopamine concentration in other areas of central nervous system. In addition, exercise probably treated Parkinson's disease by increasing levels of dopamine in the brain. However, since exercise produces stress in the body, it was less successful in treating the disease compared to red grape juice. |
| first_indexed | 2024-03-12T11:14:11Z |
| format | Article |
| id | doaj.art-f076ba032d3c4e55a7ac5ca05955e59d |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T11:14:11Z |
| publishDate | 2012-01-01 |
| publisher | Isfahan University of Medical Sciences |
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| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-f076ba032d3c4e55a7ac5ca05955e59d2023-09-02T02:24:43ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2012-01-012916219081917796The Effects of Red Grape Juice and Exercise on Parkinson's Disease in Male RatsFatemeh Eshraghi Jazi0Hojjatollah Alaei1Hamid Azizi Malekabadi2Ali Asghar Pilehvarian3Mahin Gharavi Naeini4Mohammad Saleh Ahmadi5Emad Shah-Mansouri6Zahra Ciahmard7Department of Biology, Payam-e-Noor University, Isfahan, IranProfessor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Biology, Khorasgan Branch, Islamic Azad University, Isfahan, IranAssistant Professor, Department of Biology, Payam-e-Noor University, Isfahan, IranDepartment of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBaneh Agricultural Jihad, Baneh, IranMedical Plants Research Center, Isfahan Agricultural Jihad, Isfahan, IranDepartment of Biology, Payam-e-Noor University, Isfahan, IranBackground: Neural degeneration is induced by production of oxidant agents in neural pools. Red grape juice has antioxidant agents. Exercise can be able to protect dopaminergic neurons of brain. Therefore, it seems that red grape juice and exercise can prevent neural impairment in neurodegenerative diseases. In this study, neuroprotective effects of red grape juice and exercise on Parkinson's disease in male rats were compared. Methods: In order to create Parkinson's in rats, they were received unilateral infusion of 6-hydroxydopamine (6-OHDA) into substantia nigra pars compacta by a stereotaxic apparatus. Two weeks after surgery, the rats were treated with red grape juice and exercise for 1 month. In order to estimate the extent of lesion, they received intraperitoneal apomorphine. The number of rotations until 1 hour after injection was calculated as the main parameter for evaluation of Parkinson's disease. Findings: Our results showed that red grape juice decreased the signs of Parkinson's disease compared to other groups. In addition, groups with Parkinson's disease which did not receive red grape juice presented the highest numbers of rotations. The results also indicated that injection of 6-OHDA induced Parkinson's disease whose signs occurred as rotations resulted by the administration of dopamine agonist agents. These effects were reduced using red grape juice. Exercise also reduced rotations in treated groups with Parkinson's disease. Moreover, red grape juice reduced rotations in Parkinson's disease rats significantly more than exercise. Conclusion: The main place of release of dopamine in the brain is substantia nigra nucleus. This nucleus has an important role in controlling and coordination of voluntary activities of skeletal muscles. Injection of 6-OHDA into this area decreased the release of dopamine and finally induced Parkinson's disease. Using red grape juice probably treats this disease via compensation of dopamine concentration in other areas of central nervous system. In addition, exercise probably treated Parkinson's disease by increasing levels of dopamine in the brain. However, since exercise produces stress in the body, it was less successful in treating the disease compared to red grape juice.http://jims.mui.ac.ir/index.php/jims/article/view/444Parkinson's diseaseRed grape juiceExerciseApomorphine6-hydroxydopamine |
| spellingShingle | Fatemeh Eshraghi Jazi Hojjatollah Alaei Hamid Azizi Malekabadi Ali Asghar Pilehvarian Mahin Gharavi Naeini Mohammad Saleh Ahmadi Emad Shah-Mansouri Zahra Ciahmard The Effects of Red Grape Juice and Exercise on Parkinson's Disease in Male Rats مجله دانشکده پزشکی اصفهان Parkinson's disease Red grape juice Exercise Apomorphine 6-hydroxydopamine |
| title | The Effects of Red Grape Juice and Exercise on Parkinson's Disease in Male Rats |
| title_full | The Effects of Red Grape Juice and Exercise on Parkinson's Disease in Male Rats |
| title_fullStr | The Effects of Red Grape Juice and Exercise on Parkinson's Disease in Male Rats |
| title_full_unstemmed | The Effects of Red Grape Juice and Exercise on Parkinson's Disease in Male Rats |
| title_short | The Effects of Red Grape Juice and Exercise on Parkinson's Disease in Male Rats |
| title_sort | effects of red grape juice and exercise on parkinson s disease in male rats |
| topic | Parkinson's disease Red grape juice Exercise Apomorphine 6-hydroxydopamine |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/444 |
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