Highly pathogenic avian influenza A(H5N1) virus in a common bottlenose dolphin (Tursiops truncatus) in Florida
Abstract Since late 2021, highly pathogenic avian influenza (HPAI) viruses of A/goose/Guangdong/1/1996 (H5N1) lineage have caused widespread mortality in wild birds and poultry in the United States. Concomitant with the spread of HPAI viruses in birds are increasing numbers of mammalian infections,...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-06173-x |
| _version_ | 1827277002050109440 |
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| author | Allison Murawski Thomas Fabrizio Robert Ossiboff Christina Kackos Trushar Jeevan Jeremy C. Jones Ahmed Kandeil David Walker Jasmine C. M. Turner Christopher Patton Elena A. Govorkova Helena Hauck Suzanna Mickey Brittany Barbeau Y. Reddy Bommineni Mia Torchetti Kristina Lantz Lisa Kercher Andrew B. Allison Peter Vogel Michael Walsh Richard J. Webby |
| author_facet | Allison Murawski Thomas Fabrizio Robert Ossiboff Christina Kackos Trushar Jeevan Jeremy C. Jones Ahmed Kandeil David Walker Jasmine C. M. Turner Christopher Patton Elena A. Govorkova Helena Hauck Suzanna Mickey Brittany Barbeau Y. Reddy Bommineni Mia Torchetti Kristina Lantz Lisa Kercher Andrew B. Allison Peter Vogel Michael Walsh Richard J. Webby |
| author_sort | Allison Murawski |
| collection | DOAJ |
| description | Abstract Since late 2021, highly pathogenic avian influenza (HPAI) viruses of A/goose/Guangdong/1/1996 (H5N1) lineage have caused widespread mortality in wild birds and poultry in the United States. Concomitant with the spread of HPAI viruses in birds are increasing numbers of mammalian infections, including wild and captive mesocarnivores and carnivores with central nervous system involvement. Here we report HPAI, A(H5N1) of clade 2.3.4.4b, in a common bottlenose dolphin (Tursiops truncatus) from Florida, United States. Pathological findings include neuronal necrosis and inflammation of the brain and meninges, and quantitative real time RT-PCR reveal the brain carried the highest viral load. Virus isolated from the brain contains a S246N neuraminidase substitution which leads to reduced inhibition by neuraminidase inhibitor oseltamivir. The increased prevalence of A(H5N1) viruses in atypical avian hosts and its cross-species transmission into mammalian species highlights the public health importance of continued disease surveillance and biosecurity protocols. |
| first_indexed | 2024-04-24T07:13:36Z |
| format | Article |
| id | doaj.art-f077851e17244c52914bd58d8ee3025c |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-24T07:13:36Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-f077851e17244c52914bd58d8ee3025c2024-04-21T11:27:29ZengNature PortfolioCommunications Biology2399-36422024-04-017111110.1038/s42003-024-06173-xHighly pathogenic avian influenza A(H5N1) virus in a common bottlenose dolphin (Tursiops truncatus) in FloridaAllison Murawski0Thomas Fabrizio1Robert Ossiboff2Christina Kackos3Trushar Jeevan4Jeremy C. Jones5Ahmed Kandeil6David Walker7Jasmine C. M. Turner8Christopher Patton9Elena A. Govorkova10Helena Hauck11Suzanna Mickey12Brittany Barbeau13Y. Reddy Bommineni14Mia Torchetti15Kristina Lantz16Lisa Kercher17Andrew B. Allison18Peter Vogel19Michael Walsh20Richard J. Webby21Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of FloridaDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of FloridaDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of FloridaDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of FloridaDepartment of Large Animal Clinical Sciences, College of Veterinary Medicine, University of FloridaBronson Animal Disease Diagnostic LaboratoryNational Veterinary Services Laboratories, Animal and Plant Health Inspection Service (APHIS), U.S. Department of Agriculture (USDA)National Veterinary Services Laboratories, Animal and Plant Health Inspection Service (APHIS), U.S. Department of Agriculture (USDA)Department of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of FloridaComparative Pathology Core, St. Jude Children’s Research HospitalDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of FloridaDepartment of Infectious Diseases, St. Jude Children’s Research HospitalAbstract Since late 2021, highly pathogenic avian influenza (HPAI) viruses of A/goose/Guangdong/1/1996 (H5N1) lineage have caused widespread mortality in wild birds and poultry in the United States. Concomitant with the spread of HPAI viruses in birds are increasing numbers of mammalian infections, including wild and captive mesocarnivores and carnivores with central nervous system involvement. Here we report HPAI, A(H5N1) of clade 2.3.4.4b, in a common bottlenose dolphin (Tursiops truncatus) from Florida, United States. Pathological findings include neuronal necrosis and inflammation of the brain and meninges, and quantitative real time RT-PCR reveal the brain carried the highest viral load. Virus isolated from the brain contains a S246N neuraminidase substitution which leads to reduced inhibition by neuraminidase inhibitor oseltamivir. The increased prevalence of A(H5N1) viruses in atypical avian hosts and its cross-species transmission into mammalian species highlights the public health importance of continued disease surveillance and biosecurity protocols.https://doi.org/10.1038/s42003-024-06173-x |
| spellingShingle | Allison Murawski Thomas Fabrizio Robert Ossiboff Christina Kackos Trushar Jeevan Jeremy C. Jones Ahmed Kandeil David Walker Jasmine C. M. Turner Christopher Patton Elena A. Govorkova Helena Hauck Suzanna Mickey Brittany Barbeau Y. Reddy Bommineni Mia Torchetti Kristina Lantz Lisa Kercher Andrew B. Allison Peter Vogel Michael Walsh Richard J. Webby Highly pathogenic avian influenza A(H5N1) virus in a common bottlenose dolphin (Tursiops truncatus) in Florida Communications Biology |
| title | Highly pathogenic avian influenza A(H5N1) virus in a common bottlenose dolphin (Tursiops truncatus) in Florida |
| title_full | Highly pathogenic avian influenza A(H5N1) virus in a common bottlenose dolphin (Tursiops truncatus) in Florida |
| title_fullStr | Highly pathogenic avian influenza A(H5N1) virus in a common bottlenose dolphin (Tursiops truncatus) in Florida |
| title_full_unstemmed | Highly pathogenic avian influenza A(H5N1) virus in a common bottlenose dolphin (Tursiops truncatus) in Florida |
| title_short | Highly pathogenic avian influenza A(H5N1) virus in a common bottlenose dolphin (Tursiops truncatus) in Florida |
| title_sort | highly pathogenic avian influenza a h5n1 virus in a common bottlenose dolphin tursiops truncatus in florida |
| url | https://doi.org/10.1038/s42003-024-06173-x |
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