Macrophages Interaction and MicroRNA Interplay in the Modulation of Cancer Development and Metastasis
Advancement in cancer research has shown that the tumor microenvironment plays a crucial role in the installation, progression, and dissemination of cancer cells. Among the heterogeneous panel of cells within the malignant microenvironment are tumor-associated macrophages that are sustaining the mal...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.00870/full |
| _version_ | 1818019854987296768 |
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| author | Ioana Iurca Ioana Iurca Alexandru Tirpe Alexandru Tirpe Alina-Andreea Zimta Cristian Moldovan Diana Gulei Ondřej Slabý Ondřej Slabý Gerolama Condorelli Ioana Berindan-Neagoe Ioana Berindan-Neagoe Ioana Berindan-Neagoe |
| author_facet | Ioana Iurca Ioana Iurca Alexandru Tirpe Alexandru Tirpe Alina-Andreea Zimta Cristian Moldovan Diana Gulei Ondřej Slabý Ondřej Slabý Gerolama Condorelli Ioana Berindan-Neagoe Ioana Berindan-Neagoe Ioana Berindan-Neagoe |
| author_sort | Ioana Iurca |
| collection | DOAJ |
| description | Advancement in cancer research has shown that the tumor microenvironment plays a crucial role in the installation, progression, and dissemination of cancer cells. Among the heterogeneous panel of cells within the malignant microenvironment are tumor-associated macrophages that are sustaining the malignant cells through strict feedback mechanisms and spatial distribution. Considering that the presence of metastasis is one of the main feature associated with decreased survival rates among patients, in the present article we briefly present the involvement of tumor-associated macrophages in the hallmarks of metastasis and their microRNA-related regulation with a focus on lung cancer in order to coordinate the vast information under one pathology. As shown, these cells have emerged as coordinators of immunosuppression, angiogenesis and lymphangiogenesis, vessel intravasation and extravasation of cancer cells, and premetastatic niche formation, transforming the macrophages in potential therapeutic targets and also prognostic markers according to their density within the tumor and polarization phenotype. An indirect therapeutic approach on tumor-associated macrophages can be also represented by regulation of microRNAs involved in their polarization and implicit oncogenic features. Examples of these microRNAs consist in the highly studied miR-21 and miR-155, but also other microRNA with less feedback in the literature: miR-1207-5p, miR-193b, miR-320a, and others. |
| first_indexed | 2024-04-14T07:58:05Z |
| format | Article |
| id | doaj.art-f077c6bbe3fd4a548c16552d44b615ef |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T07:58:05Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f077c6bbe3fd4a548c16552d44b615ef2022-12-22T02:04:59ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-05-011110.3389/fimmu.2020.00870536677Macrophages Interaction and MicroRNA Interplay in the Modulation of Cancer Development and MetastasisIoana Iurca0Ioana Iurca1Alexandru Tirpe2Alexandru Tirpe3Alina-Andreea Zimta4Cristian Moldovan5Diana Gulei6Ondřej Slabý7Ondřej Slabý8Gerolama Condorelli9Ioana Berindan-Neagoe10Ioana Berindan-Neagoe11Ioana Berindan-Neagoe12Tumor Biology Department, The Oncology Institute “Prof. Dr. Ion Chiricuta”, Cluj-Napoca, RomaniaResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaFaculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaResearch Center for Advanced Medicine—Medfuture, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaResearch Center for Advanced Medicine—Medfuture, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaResearch Center for Advanced Medicine—Medfuture, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaCentre for Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech RepublicDepartment of Comprehensive Cancer Care, Faculty of Medicine, Masaryk Memorial Cancer Institute, Masaryk University, Brno, Czech RepublicDepartment of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, Naples, ItalyResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaResearch Center for Advanced Medicine—Medfuture, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Functional Genomics and Experimental Pathology, The Oncology Institute “Prof. Dr. Ion Chiricuta,”Cluj-Napoca, RomaniaAdvancement in cancer research has shown that the tumor microenvironment plays a crucial role in the installation, progression, and dissemination of cancer cells. Among the heterogeneous panel of cells within the malignant microenvironment are tumor-associated macrophages that are sustaining the malignant cells through strict feedback mechanisms and spatial distribution. Considering that the presence of metastasis is one of the main feature associated with decreased survival rates among patients, in the present article we briefly present the involvement of tumor-associated macrophages in the hallmarks of metastasis and their microRNA-related regulation with a focus on lung cancer in order to coordinate the vast information under one pathology. As shown, these cells have emerged as coordinators of immunosuppression, angiogenesis and lymphangiogenesis, vessel intravasation and extravasation of cancer cells, and premetastatic niche formation, transforming the macrophages in potential therapeutic targets and also prognostic markers according to their density within the tumor and polarization phenotype. An indirect therapeutic approach on tumor-associated macrophages can be also represented by regulation of microRNAs involved in their polarization and implicit oncogenic features. Examples of these microRNAs consist in the highly studied miR-21 and miR-155, but also other microRNA with less feedback in the literature: miR-1207-5p, miR-193b, miR-320a, and others.https://www.frontiersin.org/article/10.3389/fimmu.2020.00870/fullmacrophagecancermetastasismicroRNAinvasion |
| spellingShingle | Ioana Iurca Ioana Iurca Alexandru Tirpe Alexandru Tirpe Alina-Andreea Zimta Cristian Moldovan Diana Gulei Ondřej Slabý Ondřej Slabý Gerolama Condorelli Ioana Berindan-Neagoe Ioana Berindan-Neagoe Ioana Berindan-Neagoe Macrophages Interaction and MicroRNA Interplay in the Modulation of Cancer Development and Metastasis Frontiers in Immunology macrophage cancer metastasis microRNA invasion |
| title | Macrophages Interaction and MicroRNA Interplay in the Modulation of Cancer Development and Metastasis |
| title_full | Macrophages Interaction and MicroRNA Interplay in the Modulation of Cancer Development and Metastasis |
| title_fullStr | Macrophages Interaction and MicroRNA Interplay in the Modulation of Cancer Development and Metastasis |
| title_full_unstemmed | Macrophages Interaction and MicroRNA Interplay in the Modulation of Cancer Development and Metastasis |
| title_short | Macrophages Interaction and MicroRNA Interplay in the Modulation of Cancer Development and Metastasis |
| title_sort | macrophages interaction and microrna interplay in the modulation of cancer development and metastasis |
| topic | macrophage cancer metastasis microRNA invasion |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.00870/full |
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