PREVALENCE OF ANTI-HBC IN HBSAG-NEGATIVE POPULATION
Background. Among the various serological markers employed in the hepatitis B virus (HBV) differential laboratory diagnosis, serum HBsAg is considered the most reliable. In order to characterise the HBV infection, another important diagnostic marker is employed – the HBc antibody (anti-HBc). There...
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| Format: | Article |
| Language: | English |
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National Center of Infectious and Parasitic Diseases
2020-05-01
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| Series: | Problems of Infectious and Parasitic Diseases |
| Subjects: | |
| Online Access: | https://pipd.ncipd.org/index.php/pipd/article/view/31 |
| _version_ | 1827946674614435840 |
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| author | Daniel Ivanov Tencho Tenev Elica Golkocheva-Markova |
| author_facet | Daniel Ivanov Tencho Tenev Elica Golkocheva-Markova |
| author_sort | Daniel Ivanov |
| collection | DOAJ |
| description |
Background. Among the various serological markers employed in the hepatitis B virus (HBV) differential laboratory diagnosis, serum HBsAg is considered the most reliable. In order to characterise the HBV infection, another important diagnostic marker is employed – the HBc antibody (anti-HBc). There are three categories of anti-HBc-positive individuals: patients with HBV immunity, patients with chronic HBV and individuals with the so-called isolated anti-HBc pattern. The current study aimed to evaluate the presence of anti-HBc in patients negative for HBsAg whose clinical diagnosis was acute viral hepatitis.
Material and methods. A total of 88 specimens were examined, of which 75 sera were from prospective patients diagnosed with acute viral hepatitis, and 13 sera from breast milk donors. Antibodies against the hepatitis B core antigen were detected by enzyme-linked immunosorbent assay (ELISA).
Results. Twenty-eight (32%) of all tested samples were positive for anti-HBc. Nineteen samples belonged to male and 9 to female patients. One positive sample was from a breast milk donor. Two age groups, namely 46-55 years and 56-65 years, demonstrated the highest rate of anti-HBc positivity. Among the other age groups positivity rates varied from 15% to 36%. The results demonstrated a linear trend of increasing anti-HBc prevalence with increasing age.
Conclusions. Considering the highest rate of anti-HBc positivity being demonstrated in the age range 46-65 years, it could be assumed that a sufficient number of risk factors accumulate over time resulting in greater population susceptibility to HBV infection.
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| first_indexed | 2024-03-13T11:04:57Z |
| format | Article |
| id | doaj.art-f07aa1969f5e42f79be3ff57019d6461 |
| institution | Directory Open Access Journal |
| issn | 0204-9155 2815-2808 |
| language | English |
| last_indexed | 2024-03-13T11:04:57Z |
| publishDate | 2020-05-01 |
| publisher | National Center of Infectious and Parasitic Diseases |
| record_format | Article |
| series | Problems of Infectious and Parasitic Diseases |
| spelling | doaj.art-f07aa1969f5e42f79be3ff57019d64612023-05-16T09:17:20ZengNational Center of Infectious and Parasitic DiseasesProblems of Infectious and Parasitic Diseases0204-91552815-28082020-05-0148110.58395/pipd.v48i1.31PREVALENCE OF ANTI-HBC IN HBSAG-NEGATIVE POPULATIONDaniel Ivanov0Tencho Tenev1Elica Golkocheva-Markova2Sofia University “St. Kliment Ohridski”National Centre of Infectious and Parasitic DiseasesNational Centre of Infectious and Parasitic Diseases Background. Among the various serological markers employed in the hepatitis B virus (HBV) differential laboratory diagnosis, serum HBsAg is considered the most reliable. In order to characterise the HBV infection, another important diagnostic marker is employed – the HBc antibody (anti-HBc). There are three categories of anti-HBc-positive individuals: patients with HBV immunity, patients with chronic HBV and individuals with the so-called isolated anti-HBc pattern. The current study aimed to evaluate the presence of anti-HBc in patients negative for HBsAg whose clinical diagnosis was acute viral hepatitis. Material and methods. A total of 88 specimens were examined, of which 75 sera were from prospective patients diagnosed with acute viral hepatitis, and 13 sera from breast milk donors. Antibodies against the hepatitis B core antigen were detected by enzyme-linked immunosorbent assay (ELISA). Results. Twenty-eight (32%) of all tested samples were positive for anti-HBc. Nineteen samples belonged to male and 9 to female patients. One positive sample was from a breast milk donor. Two age groups, namely 46-55 years and 56-65 years, demonstrated the highest rate of anti-HBc positivity. Among the other age groups positivity rates varied from 15% to 36%. The results demonstrated a linear trend of increasing anti-HBc prevalence with increasing age. Conclusions. Considering the highest rate of anti-HBc positivity being demonstrated in the age range 46-65 years, it could be assumed that a sufficient number of risk factors accumulate over time resulting in greater population susceptibility to HBV infection. https://pipd.ncipd.org/index.php/pipd/article/view/31HBVanti-HBcacute hepatitis |
| spellingShingle | Daniel Ivanov Tencho Tenev Elica Golkocheva-Markova PREVALENCE OF ANTI-HBC IN HBSAG-NEGATIVE POPULATION Problems of Infectious and Parasitic Diseases HBV anti-HBc acute hepatitis |
| title | PREVALENCE OF ANTI-HBC IN HBSAG-NEGATIVE POPULATION |
| title_full | PREVALENCE OF ANTI-HBC IN HBSAG-NEGATIVE POPULATION |
| title_fullStr | PREVALENCE OF ANTI-HBC IN HBSAG-NEGATIVE POPULATION |
| title_full_unstemmed | PREVALENCE OF ANTI-HBC IN HBSAG-NEGATIVE POPULATION |
| title_short | PREVALENCE OF ANTI-HBC IN HBSAG-NEGATIVE POPULATION |
| title_sort | prevalence of anti hbc in hbsag negative population |
| topic | HBV anti-HBc acute hepatitis |
| url | https://pipd.ncipd.org/index.php/pipd/article/view/31 |
| work_keys_str_mv | AT danielivanov prevalenceofantihbcinhbsagnegativepopulation AT tenchotenev prevalenceofantihbcinhbsagnegativepopulation AT elicagolkochevamarkova prevalenceofantihbcinhbsagnegativepopulation |