Cadmium Induced Apoptosis in MG63 Cells by Increasing ROS, Activation of p38 MAPK and Inhibition of ERK 1/2 Pathways

Cadmium Induced Apoptosis in MG63 Cells by Increasing ROS, Activation of p38 MAPK and Inhibition of ERK 1/2 Pathways

Background/Aims: Cadmium (Cd) induces apoptosis in different kinds of cells, including osteoblasts, both in vivo and in vitro. However, little is known about the mechanisms by which Cd induces apoptosis. Methods: In the present study, we used the human osteosarcoma cell line MG63, which has characte...

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Bibliographic Details
Main Authors: Kong-He Hu, Wen-Xue Li, Min-Ying Sun, She-Bing Zhang, Cai-Xia Fan, Qiang Wu, Wei Zhu, Xin Xu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
p38MAPK
ERK1/2
Reactive oxygen species (ROS)
Apoptosis
MG63 cell
Cadmium
Online Access:http://www.karger.com/Article/FullText/430127

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