Organ-on-a-Chip: Design and Simulation of Various Microfluidic Channel Geometries for the Influence of Fluid Dynamic Parameters
Shear stress, pressure, and flow rate are fluid dynamic parameters that can lead to changes in the morphology, proliferation, function, and survival of many cell types and have a determinant impact on tissue function and viability. Microfluidic devices are promising tools to investigate these parame...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/8/3829 |
| _version_ | 1797437056806289408 |
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| author | Francesca Pisapia Wamadeva Balachandran Manoochehr Rasekh |
| author_facet | Francesca Pisapia Wamadeva Balachandran Manoochehr Rasekh |
| author_sort | Francesca Pisapia |
| collection | DOAJ |
| description | Shear stress, pressure, and flow rate are fluid dynamic parameters that can lead to changes in the morphology, proliferation, function, and survival of many cell types and have a determinant impact on tissue function and viability. Microfluidic devices are promising tools to investigate these parameters and fluid behaviour within different microchannel geometries. This study discusses and analyses different designed microfluidic channel geometries regarding the influence of fluid dynamic parameters on their microenvironment at specified fluidic parameters. The results demonstrate that in the circular microchamber, the velocity and shear stress profiles assume a parabolic shape with a maximum velocity occurring in the centre of the chamber and a minimum velocity at the walls. The longitudinal microchannel shows a uniform velocity and shear stress profile throughout the microchannel. Simulation studies for the two geometries with three parallel microchannels showed that in proximity to the micropillars, the velocity and shear stress profiles decreased. Moreover, the pressure is inversely proportional to the width and directly proportional to the flow rate within the microfluidic channels. The simulations showed that the velocity and wall shear stress indicated different values at different flow rates. It was also found that the width and height of the microfluidic channels could affect both velocity and shear stress profiles, contributing to the control of shear stress. The study has demonstrated strategies to predict and control the effects of these forces and the potential as an alternative to conventional cell culture as well as to recapitulate the cell- and organ-specific microenvironment. |
| first_indexed | 2024-03-09T11:13:29Z |
| format | Article |
| id | doaj.art-f07c0746e1cf4774b2b8b4c2c510f4eb |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T11:13:29Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-f07c0746e1cf4774b2b8b4c2c510f4eb2023-12-01T00:39:39ZengMDPI AGApplied Sciences2076-34172022-04-01128382910.3390/app12083829Organ-on-a-Chip: Design and Simulation of Various Microfluidic Channel Geometries for the Influence of Fluid Dynamic ParametersFrancesca Pisapia0Wamadeva Balachandran1Manoochehr Rasekh2College of Engineering, Design and Physical Sciences, Brunel University London, Uxbridge, London UB8 3PH, UKCollege of Engineering, Design and Physical Sciences, Brunel University London, Uxbridge, London UB8 3PH, UKCollege of Engineering, Design and Physical Sciences, Brunel University London, Uxbridge, London UB8 3PH, UKShear stress, pressure, and flow rate are fluid dynamic parameters that can lead to changes in the morphology, proliferation, function, and survival of many cell types and have a determinant impact on tissue function and viability. Microfluidic devices are promising tools to investigate these parameters and fluid behaviour within different microchannel geometries. This study discusses and analyses different designed microfluidic channel geometries regarding the influence of fluid dynamic parameters on their microenvironment at specified fluidic parameters. The results demonstrate that in the circular microchamber, the velocity and shear stress profiles assume a parabolic shape with a maximum velocity occurring in the centre of the chamber and a minimum velocity at the walls. The longitudinal microchannel shows a uniform velocity and shear stress profile throughout the microchannel. Simulation studies for the two geometries with three parallel microchannels showed that in proximity to the micropillars, the velocity and shear stress profiles decreased. Moreover, the pressure is inversely proportional to the width and directly proportional to the flow rate within the microfluidic channels. The simulations showed that the velocity and wall shear stress indicated different values at different flow rates. It was also found that the width and height of the microfluidic channels could affect both velocity and shear stress profiles, contributing to the control of shear stress. The study has demonstrated strategies to predict and control the effects of these forces and the potential as an alternative to conventional cell culture as well as to recapitulate the cell- and organ-specific microenvironment.https://www.mdpi.com/2076-3417/12/8/3829shear stressvelocityflow ratemicropillarsmicrochannelsmicrofluidic devices |
| spellingShingle | Francesca Pisapia Wamadeva Balachandran Manoochehr Rasekh Organ-on-a-Chip: Design and Simulation of Various Microfluidic Channel Geometries for the Influence of Fluid Dynamic Parameters Applied Sciences shear stress velocity flow rate micropillars microchannels microfluidic devices |
| title | Organ-on-a-Chip: Design and Simulation of Various Microfluidic Channel Geometries for the Influence of Fluid Dynamic Parameters |
| title_full | Organ-on-a-Chip: Design and Simulation of Various Microfluidic Channel Geometries for the Influence of Fluid Dynamic Parameters |
| title_fullStr | Organ-on-a-Chip: Design and Simulation of Various Microfluidic Channel Geometries for the Influence of Fluid Dynamic Parameters |
| title_full_unstemmed | Organ-on-a-Chip: Design and Simulation of Various Microfluidic Channel Geometries for the Influence of Fluid Dynamic Parameters |
| title_short | Organ-on-a-Chip: Design and Simulation of Various Microfluidic Channel Geometries for the Influence of Fluid Dynamic Parameters |
| title_sort | organ on a chip design and simulation of various microfluidic channel geometries for the influence of fluid dynamic parameters |
| topic | shear stress velocity flow rate micropillars microchannels microfluidic devices |
| url | https://www.mdpi.com/2076-3417/12/8/3829 |
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