A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent.

A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent.

Diffuse intrinsic pontine gliomas (DIPGs) represent a particularly lethal type of pediatric brain cancer with no effective therapeutic options. Our laboratory has previously reported the development of genetically engineered DIPG mouse models using the RCAS/tv-a system, including a model driven by P...

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Bibliographic Details
Main Authors: Kyle G Halvorson, Kelly L Barton, Kristin Schroeder, Katherine L Misuraca, Christine Hoeman, Alex Chung, Donna M Crabtree, Francisco J Cordero, Raj Singh, Ivan Spasojevic, Noah Berlow, Ranadip Pal, Oren J Becher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4352073?pdf=render

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