Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction

Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction

Single nucleotide variants (SNVs) are prevalent genetic factors shaping individual trait profiles and disease susceptibility. The recent development and optimizations of base editors, rubber and pencil genome editing tools now promise to enable direct functional assessment of SNVs in model organisms...

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Bibliographic Details
Main Authors: Alex Cornean, Jakob Gierten, Bettina Welz, Juan Luis Mateo, Thomas Thumberger, Joachim Wittbrodt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
medaka
base editing
disease variant validation
SNV
Online Access:https://elifesciences.org/articles/72124

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