Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation

Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation

Background: Coagulopathy and inflammation are hallmarks of Coronavirus disease 2019 (COVID-19) and are associated with increased mortality. Clinical and experimental data have revealed a role for neutrophil extracellular traps (NETs) in COVID-19 disease. The mechanisms that drive thrombo-inflammatio...

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Bibliographic Details
Main Authors: Hanna Englert, Chandini Rangaswamy, Carsten Deppermann, Jan-Peter Sperhake, Christoph Krisp, Danny Schreier, Emma Gordon, Sandra Konrath, Munif Haddad, Giordano Pula, Reiner K. Mailer, Hartmut Schlüter, Stefan Kluge, Florian Langer, Klaus Püschel, Kosta Panousis, Evi X. Stavrou, Coen Maas, Thomas Renné, Maike Frye
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:EBioMedicine
Subjects:
COVID-19
Thrombosis
FXII
NETs
Pulmonary thrombo-inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421001754

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