Comparative Study of Oct Angiographic Finding in Diabetic Macular Edema After Intravitreal Triamicinilone Acetonide Injection and Intravitreal Ranibizumab Injection
Background: Diabetic macular edema [DME] is a major factor contributing to the visual deterioration in most developed nations. OCTA helps visualization of diabetic microvascular changes such as microaneurysms, FAZ enlargement, and capillary non-perfusion areas.Aim of the work: This study aims to ass...
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| Format: | Article |
| Language: | English |
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Al-Azhar University, Faculty of Medicine (Damietta)
2022-10-01
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| Series: | International Journal of Medical Arts |
| Subjects: | |
| Online Access: | https://ijma.journals.ekb.eg/article_282349_babbb813a6d226e3f058947996caa39e.pdf |
| _version_ | 1827389373454221312 |
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| author | Mohamad Abu El-Maaty Hossam Mansour Abd Elmagid Tag El-Din |
| author_facet | Mohamad Abu El-Maaty Hossam Mansour Abd Elmagid Tag El-Din |
| author_sort | Mohamad Abu El-Maaty |
| collection | DOAJ |
| description | Background: Diabetic macular edema [DME] is a major factor contributing to the visual deterioration in most developed nations. OCTA helps visualization of diabetic microvascular changes such as microaneurysms, FAZ enlargement, and capillary non-perfusion areas.Aim of the work: This study aims to assess the changes in the macular perfusion of diabetic patients before and after intravitreal triamcinolone acetonide injection compared to intravitreal ranibizumab injection by OCTA. Patients and methods: This comparative study included 40 eyes having DME scheduled at Al-Azhar university hospital, Damietta. Twenty eyes underwent intravitreal ranibizumab injection [Group I] and Twenty eyes underwent intravitreal triamcinolone acetonide injection [Group II].Results: This study demonstrated that BCVA and CMT significantly improved in 1st week up to 3 months in both groups. There was no statistically significant difference between the 2 groups as regards BCVA and CMT improvement [P value > 0.05]. As regards SCP [superficial capillary plexus], and DCP [Deep capillary plexus], there was some improvement in the macular perfusion of DCP in the ranibizumab group with no difference in macular perfusion of SCP in both groups and mild worsening of DCP in the triamcinolone group. The difference between the 2 groups was not significant statistically all over follow-up periods [P value > 0.05]. Also, the difference between the baseline macular perfusion and postoperative one in each group was not significant statistically [P value > 0.05].Conclusion: Our study showed no significant changes in macular perfusion [SCP or DCP] following ranibizumab or triamcinolone injection in DME. In both groups. |
| first_indexed | 2024-03-08T16:35:48Z |
| format | Article |
| id | doaj.art-f080fa71eaa84294b49e33266448440b |
| institution | Directory Open Access Journal |
| issn | 2636-4174 2682-3780 |
| language | English |
| last_indexed | 2024-03-08T16:35:48Z |
| publishDate | 2022-10-01 |
| publisher | Al-Azhar University, Faculty of Medicine (Damietta) |
| record_format | Article |
| series | International Journal of Medical Arts |
| spelling | doaj.art-f080fa71eaa84294b49e33266448440b2024-01-05T19:38:04ZengAl-Azhar University, Faculty of Medicine (Damietta)International Journal of Medical Arts2636-41742682-37802022-10-014102741274810.21608/ijma.2023.176143.1559282349Comparative Study of Oct Angiographic Finding in Diabetic Macular Edema After Intravitreal Triamicinilone Acetonide Injection and Intravitreal Ranibizumab InjectionMohamad Abu El-Maaty0Hossam Mansour1Abd Elmagid Tag El-Din2Department of Ophthalmology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, EgyptDepartment of Ophthalmology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, EgyptDepartment of Ophthalmology, Faculty of Medicine, Al-Azhar University, Cairo, EgyptBackground: Diabetic macular edema [DME] is a major factor contributing to the visual deterioration in most developed nations. OCTA helps visualization of diabetic microvascular changes such as microaneurysms, FAZ enlargement, and capillary non-perfusion areas.Aim of the work: This study aims to assess the changes in the macular perfusion of diabetic patients before and after intravitreal triamcinolone acetonide injection compared to intravitreal ranibizumab injection by OCTA. Patients and methods: This comparative study included 40 eyes having DME scheduled at Al-Azhar university hospital, Damietta. Twenty eyes underwent intravitreal ranibizumab injection [Group I] and Twenty eyes underwent intravitreal triamcinolone acetonide injection [Group II].Results: This study demonstrated that BCVA and CMT significantly improved in 1st week up to 3 months in both groups. There was no statistically significant difference between the 2 groups as regards BCVA and CMT improvement [P value > 0.05]. As regards SCP [superficial capillary plexus], and DCP [Deep capillary plexus], there was some improvement in the macular perfusion of DCP in the ranibizumab group with no difference in macular perfusion of SCP in both groups and mild worsening of DCP in the triamcinolone group. The difference between the 2 groups was not significant statistically all over follow-up periods [P value > 0.05]. Also, the difference between the baseline macular perfusion and postoperative one in each group was not significant statistically [P value > 0.05].Conclusion: Our study showed no significant changes in macular perfusion [SCP or DCP] following ranibizumab or triamcinolone injection in DME. In both groups.https://ijma.journals.ekb.eg/article_282349_babbb813a6d226e3f058947996caa39e.pdfdmeranibizumabtriamcinoloneocta |
| spellingShingle | Mohamad Abu El-Maaty Hossam Mansour Abd Elmagid Tag El-Din Comparative Study of Oct Angiographic Finding in Diabetic Macular Edema After Intravitreal Triamicinilone Acetonide Injection and Intravitreal Ranibizumab Injection International Journal of Medical Arts dme ranibizumab triamcinolone octa |
| title | Comparative Study of Oct Angiographic Finding in Diabetic Macular Edema After Intravitreal Triamicinilone Acetonide Injection and Intravitreal Ranibizumab Injection |
| title_full | Comparative Study of Oct Angiographic Finding in Diabetic Macular Edema After Intravitreal Triamicinilone Acetonide Injection and Intravitreal Ranibizumab Injection |
| title_fullStr | Comparative Study of Oct Angiographic Finding in Diabetic Macular Edema After Intravitreal Triamicinilone Acetonide Injection and Intravitreal Ranibizumab Injection |
| title_full_unstemmed | Comparative Study of Oct Angiographic Finding in Diabetic Macular Edema After Intravitreal Triamicinilone Acetonide Injection and Intravitreal Ranibizumab Injection |
| title_short | Comparative Study of Oct Angiographic Finding in Diabetic Macular Edema After Intravitreal Triamicinilone Acetonide Injection and Intravitreal Ranibizumab Injection |
| title_sort | comparative study of oct angiographic finding in diabetic macular edema after intravitreal triamicinilone acetonide injection and intravitreal ranibizumab injection |
| topic | dme ranibizumab triamcinolone octa |
| url | https://ijma.journals.ekb.eg/article_282349_babbb813a6d226e3f058947996caa39e.pdf |
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