No association between antenatal common mental disorders in low-obstetric risk women and adverse birth outcomes in their offspring: results from the CDS study in Ghana and Côte D'Ivoire.
<h4>Background</h4>Evidence linking common mental disorders (CMD) in pregnant women to adverse birth outcomes is inconsistent, and studies often failed to control for pregnancy complications. This study aimed to explore the association between antenatal depression and anxiety symptoms an...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24260460/?tool=EBI |
| _version_ | 1818338212045651968 |
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| author | Carola Bindt Nan Guo Marguerite Te Bonle John Appiah-Poku Rebecca Hinz Dana Barthel Stefanie Schoppen Torsten Feldt Claus Barkmann Mathurin Koffi Wibke Loag Samuel Blay Nguah Kirsten A Eberhardt Harry Tagbor Eliezer N'goran Stephan Ehrhardt International CDS Study Group |
| author_facet | Carola Bindt Nan Guo Marguerite Te Bonle John Appiah-Poku Rebecca Hinz Dana Barthel Stefanie Schoppen Torsten Feldt Claus Barkmann Mathurin Koffi Wibke Loag Samuel Blay Nguah Kirsten A Eberhardt Harry Tagbor Eliezer N'goran Stephan Ehrhardt International CDS Study Group |
| author_sort | Carola Bindt |
| collection | DOAJ |
| description | <h4>Background</h4>Evidence linking common mental disorders (CMD) in pregnant women to adverse birth outcomes is inconsistent, and studies often failed to control for pregnancy complications. This study aimed to explore the association between antenatal depression and anxiety symptoms and birth outcomes in a low-obstetric risk sample of mother/child dyads in Ghana and Côte d'Ivoire.<h4>Methods</h4>In 2010-2011, a prospective cohort of 1030 women in their third trimester in Ghana and Côte d'Ivoire was enrolled. Depression and anxiety were assessed in the third trimester using the Patient Health Questionnaire depression module and the 7-item Generalized Anxiety Disorder scale. 719 mother/child dyads were included in the analysis. We constructed multivariate regression models to estimate the association between CMD and low birth weight (LBW), and preterm birth (PTB) to control for potential confounders.<h4>Results</h4>The prevalence of depression and anxiety symptoms were 28.9% and 14.2% respectively. The mean birth weight was 3172.1g (SD 440.6) and the prevalence of LBW was 1.7%. The mean gestational age was 39.6 weeks and the proportion of PTB was 4%. Multivariate linear regression revealed no significant association between maternal depression (B=52.2, 95% CI -18.2 122.6, p=0.15) or anxiety (B=17.1, 95% CI -74.6 108.7, p=0.72) and birth weight. Yet, low socio-economic status, female sex of the child, and younger maternal age were associated with lower birth weight. Multivariate logistic regression suggested no significant association between maternal depression (OR: 2.1, 95% CI 0.8 5.6, p=0.15) or anxiety (OR: 1.8, 95% CI 0.6 5.5, p=0.29) with PTB.<h4>Conclusions</h4>Our data suggests that depression and/or anxiety in the 3(rd) trimester of pregnancy are not independent predictors of adverse birth outcomes in low obstetric risk women. The role of pregnancy complications as confounders or effect modifiers in studies of maternal CMD and their impact on birth outcomes should be investigated. |
| first_indexed | 2024-12-13T15:07:31Z |
| format | Article |
| id | doaj.art-f082505aaf324bcfa1ef35ae35bbff9b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T15:07:31Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f082505aaf324bcfa1ef35ae35bbff9b2022-12-21T23:40:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e8071110.1371/journal.pone.0080711No association between antenatal common mental disorders in low-obstetric risk women and adverse birth outcomes in their offspring: results from the CDS study in Ghana and Côte D'Ivoire.Carola BindtNan GuoMarguerite Te BonleJohn Appiah-PokuRebecca HinzDana BarthelStefanie SchoppenTorsten FeldtClaus BarkmannMathurin KoffiWibke LoagSamuel Blay NguahKirsten A EberhardtHarry TagborEliezer N'goranStephan EhrhardtInternational CDS Study Group<h4>Background</h4>Evidence linking common mental disorders (CMD) in pregnant women to adverse birth outcomes is inconsistent, and studies often failed to control for pregnancy complications. This study aimed to explore the association between antenatal depression and anxiety symptoms and birth outcomes in a low-obstetric risk sample of mother/child dyads in Ghana and Côte d'Ivoire.<h4>Methods</h4>In 2010-2011, a prospective cohort of 1030 women in their third trimester in Ghana and Côte d'Ivoire was enrolled. Depression and anxiety were assessed in the third trimester using the Patient Health Questionnaire depression module and the 7-item Generalized Anxiety Disorder scale. 719 mother/child dyads were included in the analysis. We constructed multivariate regression models to estimate the association between CMD and low birth weight (LBW), and preterm birth (PTB) to control for potential confounders.<h4>Results</h4>The prevalence of depression and anxiety symptoms were 28.9% and 14.2% respectively. The mean birth weight was 3172.1g (SD 440.6) and the prevalence of LBW was 1.7%. The mean gestational age was 39.6 weeks and the proportion of PTB was 4%. Multivariate linear regression revealed no significant association between maternal depression (B=52.2, 95% CI -18.2 122.6, p=0.15) or anxiety (B=17.1, 95% CI -74.6 108.7, p=0.72) and birth weight. Yet, low socio-economic status, female sex of the child, and younger maternal age were associated with lower birth weight. Multivariate logistic regression suggested no significant association between maternal depression (OR: 2.1, 95% CI 0.8 5.6, p=0.15) or anxiety (OR: 1.8, 95% CI 0.6 5.5, p=0.29) with PTB.<h4>Conclusions</h4>Our data suggests that depression and/or anxiety in the 3(rd) trimester of pregnancy are not independent predictors of adverse birth outcomes in low obstetric risk women. The role of pregnancy complications as confounders or effect modifiers in studies of maternal CMD and their impact on birth outcomes should be investigated.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24260460/?tool=EBI |
| spellingShingle | Carola Bindt Nan Guo Marguerite Te Bonle John Appiah-Poku Rebecca Hinz Dana Barthel Stefanie Schoppen Torsten Feldt Claus Barkmann Mathurin Koffi Wibke Loag Samuel Blay Nguah Kirsten A Eberhardt Harry Tagbor Eliezer N'goran Stephan Ehrhardt International CDS Study Group No association between antenatal common mental disorders in low-obstetric risk women and adverse birth outcomes in their offspring: results from the CDS study in Ghana and Côte D'Ivoire. PLoS ONE |
| title | No association between antenatal common mental disorders in low-obstetric risk women and adverse birth outcomes in their offspring: results from the CDS study in Ghana and Côte D'Ivoire. |
| title_full | No association between antenatal common mental disorders in low-obstetric risk women and adverse birth outcomes in their offspring: results from the CDS study in Ghana and Côte D'Ivoire. |
| title_fullStr | No association between antenatal common mental disorders in low-obstetric risk women and adverse birth outcomes in their offspring: results from the CDS study in Ghana and Côte D'Ivoire. |
| title_full_unstemmed | No association between antenatal common mental disorders in low-obstetric risk women and adverse birth outcomes in their offspring: results from the CDS study in Ghana and Côte D'Ivoire. |
| title_short | No association between antenatal common mental disorders in low-obstetric risk women and adverse birth outcomes in their offspring: results from the CDS study in Ghana and Côte D'Ivoire. |
| title_sort | no association between antenatal common mental disorders in low obstetric risk women and adverse birth outcomes in their offspring results from the cds study in ghana and cote d ivoire |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24260460/?tool=EBI |
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