High flavivirus structural plasticity demonstrated by a non-spherical morphological variant
Dengue (DENV) and Zika (ZIKV) viruses normally display as smooth spherical particles, while DENV can also become bumpy-surfaced, resulting in immune evasion. Here, Morrone et al. report DENV and ZIKV infectious club-shaped particles (clubSP) that display distinct antibody binding properties.
Bibliographic Details
| Main Authors: |
Seamus R. Morrone,
Valerie S. Y. Chew,
Xin-Ni Lim,
Thiam-Seng Ng,
Victor A. Kostyuchenko,
Shuijun Zhang,
Melissa Wirawan,
Pau-Ling Chew,
Jaime Lee,
Joanne L. Tan,
Jiaqi Wang,
Ter Yong Tan,
Jian Shi,
Gavin Screaton,
Marc C. Morais,
Shee-Mei Lok |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2020-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-16925-y
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