AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation

AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation

Abstract Background Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Metastasis and relapse are the leading causes of death in MB patients. The initiation of the SHH subgroup of MB (SHH-MB) is due to the aberrant activation of Sonic Hedgehog (Shh) signaling. However,...

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Bibliographic Details
Main Authors: Jing Cai, Yue Wang, Xinfa Wang, Zihe Ai, Tianyuan Li, Xiaohong Pu, Xin Yang, Yixing Yao, Junping He, Steven Y. Cheng, Tingting Yu, Chen Liu, Shen Yue
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Cell & Bioscience
Subjects:
AMPK
Shh signaling
Medulloblastoma
Gli1
NF-κB
Online Access:https://doi.org/10.1186/s13578-023-00963-2

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