FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells
A synthetic lethal interaction is reported between the R-loop helicase Senataxin (SETX) and Fanconi anemia pathway proteins, with SETX deficiency increasing replication stress-induced chromosome fragility & activation of mitotic DNA synthesis.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-04360-2 |
| _version_ | 1797977305358794752 |
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| author | Maha Said Viviana Barra Elisa Balzano Ibtissam Talhaoui Franca Pelliccia Simona Giunta Valeria Naim |
| author_facet | Maha Said Viviana Barra Elisa Balzano Ibtissam Talhaoui Franca Pelliccia Simona Giunta Valeria Naim |
| author_sort | Maha Said |
| collection | DOAJ |
| description | A synthetic lethal interaction is reported between the R-loop helicase Senataxin (SETX) and Fanconi anemia pathway proteins, with SETX deficiency increasing replication stress-induced chromosome fragility & activation of mitotic DNA synthesis. |
| first_indexed | 2024-04-11T05:05:53Z |
| format | Article |
| id | doaj.art-f0849d7c7fe646b286b7e3c11e31f83c |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-11T05:05:53Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-f0849d7c7fe646b286b7e3c11e31f83c2022-12-25T12:25:58ZengNature PortfolioCommunications Biology2399-36422022-12-015111310.1038/s42003-022-04360-2FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cellsMaha Said0Viviana Barra1Elisa Balzano2Ibtissam Talhaoui3Franca Pelliccia4Simona Giunta5Valeria Naim6CNRS UMR9019, Université Paris-Saclay, Gustave RoussyDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of PalermoDepartment of Biology & Biotechnology “Charles Darwin”, University of Rome SapienzaCNRS UMR9019, Université Paris-Saclay, Gustave RoussyDepartment of Biology & Biotechnology “Charles Darwin”, University of Rome SapienzaDepartment of Biology & Biotechnology “Charles Darwin”, University of Rome SapienzaCNRS UMR9019, Université Paris-Saclay, Gustave RoussyA synthetic lethal interaction is reported between the R-loop helicase Senataxin (SETX) and Fanconi anemia pathway proteins, with SETX deficiency increasing replication stress-induced chromosome fragility & activation of mitotic DNA synthesis.https://doi.org/10.1038/s42003-022-04360-2 |
| spellingShingle | Maha Said Viviana Barra Elisa Balzano Ibtissam Talhaoui Franca Pelliccia Simona Giunta Valeria Naim FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells Communications Biology |
| title | FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells |
| title_full | FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells |
| title_fullStr | FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells |
| title_full_unstemmed | FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells |
| title_short | FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells |
| title_sort | fancd2 promotes mitotic rescue from transcription mediated replication stress in setx deficient cancer cells |
| url | https://doi.org/10.1038/s42003-022-04360-2 |
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