Assessment of the Salivary Level of Malondialdehyde in Localized Periodontitis Versus Generalized Periodontitis: An Analytical Cross-Sectional Study
Introduction: We aimed to compare the salivary level of malondialdehyde (MDA) in localized periodontitis versus generalized periodontitis. Methods: Nineteen healthy participants, 35 cases of generalized periodontitis, and 36 cases of localized periodontitis included in the study. The enzyme-linked i...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Dental Hypotheses |
| Subjects: | |
| Online Access: | http://www.dentalhypotheses.com/article.asp?issn=2155-8213;year=2023;volume=14;issue=3;spage=75;epage=77;aulast=Miran |
| _version_ | 1827783364772364288 |
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| author | Alla Ali Jan Miran Hadeel Mazin Akram |
| author_facet | Alla Ali Jan Miran Hadeel Mazin Akram |
| author_sort | Alla Ali Jan Miran |
| collection | DOAJ |
| description | Introduction: We aimed to compare the salivary level of malondialdehyde (MDA) in localized periodontitis versus generalized periodontitis. Methods: Nineteen healthy participants, 35 cases of generalized periodontitis, and 36 cases of localized periodontitis included in the study. The enzyme-linked immunosorbent (ELISA) assay was used to blindly quantify the amounts of MDA in saliva. Data analyzed using one-way ANOVA and Tukey’s post hoc test via R software. Results: Ninety subjects completed the study. There was a statistically significant difference among study groups (P < 0.001). The Tukey’s post hoc test showed a statistically significant difference for all pairwise compressions (P < 0.001) Conclusion: The salivary levels of MDA increase in periodontitis patients. Within limitations of this cross-sectional study, it could be concluded that salivary MDA levels may possibly be a potential biomarker to examine oxidative stress in periodontal disease. |
| first_indexed | 2024-03-11T15:46:34Z |
| format | Article |
| id | doaj.art-f084a03eadda402d9476cec429bd01ea |
| institution | Directory Open Access Journal |
| issn | 2155-8213 |
| language | English |
| last_indexed | 2024-03-11T15:46:34Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dental Hypotheses |
| spelling | doaj.art-f084a03eadda402d9476cec429bd01ea2023-10-26T06:27:42ZengWolters Kluwer Medknow PublicationsDental Hypotheses2155-82132023-01-01143757710.4103/denthyp.denthyp_16_23Assessment of the Salivary Level of Malondialdehyde in Localized Periodontitis Versus Generalized Periodontitis: An Analytical Cross-Sectional StudyAlla Ali Jan MiranHadeel Mazin AkramIntroduction: We aimed to compare the salivary level of malondialdehyde (MDA) in localized periodontitis versus generalized periodontitis. Methods: Nineteen healthy participants, 35 cases of generalized periodontitis, and 36 cases of localized periodontitis included in the study. The enzyme-linked immunosorbent (ELISA) assay was used to blindly quantify the amounts of MDA in saliva. Data analyzed using one-way ANOVA and Tukey’s post hoc test via R software. Results: Ninety subjects completed the study. There was a statistically significant difference among study groups (P < 0.001). The Tukey’s post hoc test showed a statistically significant difference for all pairwise compressions (P < 0.001) Conclusion: The salivary levels of MDA increase in periodontitis patients. Within limitations of this cross-sectional study, it could be concluded that salivary MDA levels may possibly be a potential biomarker to examine oxidative stress in periodontal disease.http://www.dentalhypotheses.com/article.asp?issn=2155-8213;year=2023;volume=14;issue=3;spage=75;epage=77;aulast=Miranelisa assaygeneralized periodontitislocalized periodontitismalondialdehydesalivaoxidative stress |
| spellingShingle | Alla Ali Jan Miran Hadeel Mazin Akram Assessment of the Salivary Level of Malondialdehyde in Localized Periodontitis Versus Generalized Periodontitis: An Analytical Cross-Sectional Study Dental Hypotheses elisa assay generalized periodontitis localized periodontitis malondialdehyde saliva oxidative stress |
| title | Assessment of the Salivary Level of Malondialdehyde in Localized Periodontitis Versus Generalized Periodontitis: An Analytical Cross-Sectional Study |
| title_full | Assessment of the Salivary Level of Malondialdehyde in Localized Periodontitis Versus Generalized Periodontitis: An Analytical Cross-Sectional Study |
| title_fullStr | Assessment of the Salivary Level of Malondialdehyde in Localized Periodontitis Versus Generalized Periodontitis: An Analytical Cross-Sectional Study |
| title_full_unstemmed | Assessment of the Salivary Level of Malondialdehyde in Localized Periodontitis Versus Generalized Periodontitis: An Analytical Cross-Sectional Study |
| title_short | Assessment of the Salivary Level of Malondialdehyde in Localized Periodontitis Versus Generalized Periodontitis: An Analytical Cross-Sectional Study |
| title_sort | assessment of the salivary level of malondialdehyde in localized periodontitis versus generalized periodontitis an analytical cross sectional study |
| topic | elisa assay generalized periodontitis localized periodontitis malondialdehyde saliva oxidative stress |
| url | http://www.dentalhypotheses.com/article.asp?issn=2155-8213;year=2023;volume=14;issue=3;spage=75;epage=77;aulast=Miran |
| work_keys_str_mv | AT allaalijanmiran assessmentofthesalivarylevelofmalondialdehydeinlocalizedperiodontitisversusgeneralizedperiodontitisananalyticalcrosssectionalstudy AT hadeelmazinakram assessmentofthesalivarylevelofmalondialdehydeinlocalizedperiodontitisversusgeneralizedperiodontitisananalyticalcrosssectionalstudy |