Development and In Vitro-In Vivo Evaluation of a Novel Sustained-Release Loxoprofen Pellet with Double Coating Layer

Development and In Vitro-In Vivo Evaluation of a Novel Sustained-Release Loxoprofen Pellet with Double Coating Layer

This study aimed to develop a novel sustained release pellet of loxoprofen sodium (LXP) by coating a dissolution-rate controlling sub-layer containing hydroxypropyl methyl cellulose (HPMC) and citric acid, and a second diffusion-rate controlling layer containing aqueous dispersion of ethyl cellulose...

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Bibliographic Details
Main Authors: Dongwei Wan, Min Zhao, Jingjing Zhang, Libiao Luan
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Pharmaceutics
Subjects:
sustained release pellets
double coating layer
loxoprofen
citric acid
pharmacokinetic studies
Online Access:https://www.mdpi.com/1999-4923/11/6/260

Internet

https://www.mdpi.com/1999-4923/11/6/260

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