Assessment of antidiabetic potential of Shilajatvadi Lauha processed with Daruharidra in streptozotocin-nicotinamide-induced diabetic rats
Objectives: To assess the antidiabetic potential of Shilajatvadi Lauha (SL) processed with Daruharidra (modified SL [MSL]) in streptozotocin (STZ)-nicotinamide (NA)-induced diabetic rats. Materials and Methods: Animals were divided into diabetic and nondiabetic groups. Type 2 diabetes in rats was i...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Indian Journal of Health Sciences and Biomedical Research KLEU |
| Subjects: | |
| Online Access: | http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2016;volume=9;issue=3;spage=308;epage=314;aulast=Singh |
| _version_ | 1819026863368962048 |
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| author | Thakur Rakesh Singh Laxmi Narayan Gupta Neeraj Kumar Vikas Kumar |
| author_facet | Thakur Rakesh Singh Laxmi Narayan Gupta Neeraj Kumar Vikas Kumar |
| author_sort | Thakur Rakesh Singh |
| collection | DOAJ |
| description | Objectives: To assess the antidiabetic potential of Shilajatvadi Lauha (SL) processed with Daruharidra (modified SL [MSL]) in streptozotocin (STZ)-nicotinamide (NA)-induced diabetic rats.
Materials and Methods: Animals were divided into diabetic and nondiabetic groups. Type 2 diabetes in rats was induced with a single dose of STZ (65 mg/kg) NA (110 mg/kg) intraperitoneal diabetic rats were treated with formulation MSL (10, 30, and 100 mg/kg) and glibenclamide (10 mg/kg) once daily for 14 days orally. After 14 days treatment, fasting blood glucose and plasma insulin were assayed. Different biochemical parameters such as total cholesterol (TC), triglycerides (TGs), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and very LDL-C (VLDL-C) were also examined.
Results: MSL significantly lowered the blood glucose and increases insulin level, which was comparable to the standard antidiabetic drug, glibenclamide. Treatment with MSL showed a significantly reduction in the levels of TC, TG, LDL-C, and VLDL-C and increases the level of HDL-C.
Conclusion: MSL possess significant antidiabetic and antihyperlipidemic activity in Type 2 diabetes mellitus rats. The results are encouraging and further studies can be used to evaluate the exact mechanism of action to develop a novel molecule that will benefit the ailing. |
| first_indexed | 2024-12-21T05:33:20Z |
| format | Article |
| id | doaj.art-f08646acb6d94ecaa0c7a2d4b7105593 |
| institution | Directory Open Access Journal |
| issn | 2542-6214 2542-6222 |
| language | English |
| last_indexed | 2024-12-21T05:33:20Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Health Sciences and Biomedical Research KLEU |
| spelling | doaj.art-f08646acb6d94ecaa0c7a2d4b71055932022-12-21T19:14:29ZengWolters Kluwer Medknow PublicationsIndian Journal of Health Sciences and Biomedical Research KLEU2542-62142542-62222016-01-019330831410.4103/2349-5006.196334Assessment of antidiabetic potential of Shilajatvadi Lauha processed with Daruharidra in streptozotocin-nicotinamide-induced diabetic ratsThakur Rakesh SinghLaxmi Narayan GuptaNeeraj KumarVikas KumarObjectives: To assess the antidiabetic potential of Shilajatvadi Lauha (SL) processed with Daruharidra (modified SL [MSL]) in streptozotocin (STZ)-nicotinamide (NA)-induced diabetic rats. Materials and Methods: Animals were divided into diabetic and nondiabetic groups. Type 2 diabetes in rats was induced with a single dose of STZ (65 mg/kg) NA (110 mg/kg) intraperitoneal diabetic rats were treated with formulation MSL (10, 30, and 100 mg/kg) and glibenclamide (10 mg/kg) once daily for 14 days orally. After 14 days treatment, fasting blood glucose and plasma insulin were assayed. Different biochemical parameters such as total cholesterol (TC), triglycerides (TGs), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and very LDL-C (VLDL-C) were also examined. Results: MSL significantly lowered the blood glucose and increases insulin level, which was comparable to the standard antidiabetic drug, glibenclamide. Treatment with MSL showed a significantly reduction in the levels of TC, TG, LDL-C, and VLDL-C and increases the level of HDL-C. Conclusion: MSL possess significant antidiabetic and antihyperlipidemic activity in Type 2 diabetes mellitus rats. The results are encouraging and further studies can be used to evaluate the exact mechanism of action to develop a novel molecule that will benefit the ailing.http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2016;volume=9;issue=3;spage=308;epage=314;aulast=SinghAntidiabeticantihyperlipidemicDaruharidraherbomineral formulationShilajatvadi Lauha |
| spellingShingle | Thakur Rakesh Singh Laxmi Narayan Gupta Neeraj Kumar Vikas Kumar Assessment of antidiabetic potential of Shilajatvadi Lauha processed with Daruharidra in streptozotocin-nicotinamide-induced diabetic rats Indian Journal of Health Sciences and Biomedical Research KLEU Antidiabetic antihyperlipidemic Daruharidra herbomineral formulation Shilajatvadi Lauha |
| title | Assessment of antidiabetic potential of Shilajatvadi Lauha processed with Daruharidra in streptozotocin-nicotinamide-induced diabetic rats |
| title_full | Assessment of antidiabetic potential of Shilajatvadi Lauha processed with Daruharidra in streptozotocin-nicotinamide-induced diabetic rats |
| title_fullStr | Assessment of antidiabetic potential of Shilajatvadi Lauha processed with Daruharidra in streptozotocin-nicotinamide-induced diabetic rats |
| title_full_unstemmed | Assessment of antidiabetic potential of Shilajatvadi Lauha processed with Daruharidra in streptozotocin-nicotinamide-induced diabetic rats |
| title_short | Assessment of antidiabetic potential of Shilajatvadi Lauha processed with Daruharidra in streptozotocin-nicotinamide-induced diabetic rats |
| title_sort | assessment of antidiabetic potential of shilajatvadi lauha processed with daruharidra in streptozotocin nicotinamide induced diabetic rats |
| topic | Antidiabetic antihyperlipidemic Daruharidra herbomineral formulation Shilajatvadi Lauha |
| url | http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2016;volume=9;issue=3;spage=308;epage=314;aulast=Singh |
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