Analysis of clinical characteristics of 554 patients with IgA nephropathy
Objective To investigate the characteristics of IgA nephropathy and clinical characteristics of different stages of renal function. Methods A total of 554 patients with clinical biopsy-proven IgA nephropathy were included in this study. Baseline clinical and laboratory data were collected. The compo...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of New Medicine
2022-06-01
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| Series: | Xin yixue |
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| Online Access: | https://www.xinyixue.cn/fileup/0253-9802/PDF/1658129417413-1816392953.pdf |
| _version_ | 1811316377191972864 |
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| author | Chen Jiexin, Tang Ruiying, Liang Bo, Xu Qingdong |
| author_facet | Chen Jiexin, Tang Ruiying, Liang Bo, Xu Qingdong |
| author_sort | Chen Jiexin, Tang Ruiying, Liang Bo, Xu Qingdong |
| collection | DOAJ |
| description | Objective To investigate the characteristics of IgA nephropathy and clinical characteristics of different stages of renal function. Methods A total of 554 patients with clinical biopsy-proven IgA nephropathy were included in this study. Baseline clinical and laboratory data were collected. The composition ratio of clinical manifestations in patients with IgA nephropathy of different ages was analyzed, clinical characteristics of patients with different CKD stages were assessed, and the correlation between serum creatinine levels and clinical indicators in IgA nephropathy patients complicated with progressive renal failure was evaluated. Results Proteinuria or hematuria were the most common clinical manifestations of patients with IgA nephropathy, followed by progressive chronic renal failure. Hematuria mainly occurred in patients aged 14-40 years. The most prevalent clinical manifestations of the young and middle-aged patients were proteinuria or proteinuria complicated with hematuria, and progressive chronic renal failure was the most common among those aged over 50 years old. The higher the pre-CKD4 stage, the higher the proteinuria level （all P < 0.05）. With the increasing CKD stage, the uric acid and CRP levels were significantly elevated, whereas the hemoglobin and albumin levels were remarkably declined （all P < 0.05）. Serum creatinine was positively correlated with age, proteinuria, triglycerides, serum uric acid, and CRP （all P < 0.05）. Conclusion High proteinuria, CRP, triglycerides and serum uric acid levels might indicate poor renal function in patients with IgA nephropathy. |
| first_indexed | 2024-04-13T11:47:46Z |
| format | Article |
| id | doaj.art-f08920efd448445e95f56f63add1278c |
| institution | Directory Open Access Journal |
| issn | 0253-9802 |
| language | zho |
| last_indexed | 2024-04-13T11:47:46Z |
| publishDate | 2022-06-01 |
| publisher | Editorial Office of Journal of New Medicine |
| record_format | Article |
| series | Xin yixue |
| spelling | doaj.art-f08920efd448445e95f56f63add1278c2022-12-22T02:48:08ZzhoEditorial Office of Journal of New MedicineXin yixue0253-98022022-06-0153643644010.3969/j.issn.0253-9802.2022.06.010Analysis of clinical characteristics of 554 patients with IgA nephropathyChen Jiexin, Tang Ruiying, Liang Bo, Xu Qingdong0△Guangzhou Medical University, Guangzhou 511436, ChinaObjective To investigate the characteristics of IgA nephropathy and clinical characteristics of different stages of renal function. Methods A total of 554 patients with clinical biopsy-proven IgA nephropathy were included in this study. Baseline clinical and laboratory data were collected. The composition ratio of clinical manifestations in patients with IgA nephropathy of different ages was analyzed, clinical characteristics of patients with different CKD stages were assessed, and the correlation between serum creatinine levels and clinical indicators in IgA nephropathy patients complicated with progressive renal failure was evaluated. Results Proteinuria or hematuria were the most common clinical manifestations of patients with IgA nephropathy, followed by progressive chronic renal failure. Hematuria mainly occurred in patients aged 14-40 years. The most prevalent clinical manifestations of the young and middle-aged patients were proteinuria or proteinuria complicated with hematuria, and progressive chronic renal failure was the most common among those aged over 50 years old. The higher the pre-CKD4 stage, the higher the proteinuria level （all P < 0.05）. With the increasing CKD stage, the uric acid and CRP levels were significantly elevated, whereas the hemoglobin and albumin levels were remarkably declined （all P < 0.05）. Serum creatinine was positively correlated with age, proteinuria, triglycerides, serum uric acid, and CRP （all P < 0.05）. Conclusion High proteinuria, CRP, triglycerides and serum uric acid levels might indicate poor renal function in patients with IgA nephropathy.https://www.xinyixue.cn/fileup/0253-9802/PDF/1658129417413-1816392953.pdf|iga nephropathy|progression of renal function|proteinuria|uric acid |
| spellingShingle | Chen Jiexin, Tang Ruiying, Liang Bo, Xu Qingdong Analysis of clinical characteristics of 554 patients with IgA nephropathy Xin yixue |iga nephropathy|progression of renal function|proteinuria|uric acid |
| title | Analysis of clinical characteristics of 554 patients with IgA nephropathy |
| title_full | Analysis of clinical characteristics of 554 patients with IgA nephropathy |
| title_fullStr | Analysis of clinical characteristics of 554 patients with IgA nephropathy |
| title_full_unstemmed | Analysis of clinical characteristics of 554 patients with IgA nephropathy |
| title_short | Analysis of clinical characteristics of 554 patients with IgA nephropathy |
| title_sort | analysis of clinical characteristics of 554 patients with iga nephropathy |
| topic | |iga nephropathy|progression of renal function|proteinuria|uric acid |
| url | https://www.xinyixue.cn/fileup/0253-9802/PDF/1658129417413-1816392953.pdf |
| work_keys_str_mv | AT chenjiexintangruiyingliangboxuqingdong analysisofclinicalcharacteristicsof554patientswithiganephropathy |