Precise Regulation of the Basal PKCγ Activity by DGKγ Is Crucial for Motor Coordination

Precise Regulation of the Basal PKCγ Activity by DGKγ Is Crucial for Motor Coordination

Diacylglycerol kinase γ (DGKγ) is a lipid kinase to convert diacylglycerol (DG) to phosphatidic acid (PA) and indirectly regulates protein kinase C γ (PKCγ) activity. We previously reported that the basal PKCγ upregulation impairs cerebellar long-term depression (LTD) in the conventional DGKγ knocko...

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Bibliographic Details
Main Authors: Ryosuke Tsumagari, Kenta Maruo, Sho Kakizawa, Shuji Ueda, Minoru Yamanoue, Hiromitsu Saito, Noboru Suzuki, Yasuhito Shirai
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
DGKγ
PKCγ
LTD
motor coordination
TRPC3
Online Access:https://www.mdpi.com/1422-0067/21/21/7866

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