Individual Radiosensitivity as a Risk Factor for the Radiation-Induced Acute Radiodermatitis
Background: Up to 95% of irradiated patients suffer from ionizing radiation (IR) induced early skin reaction, acute radiation dermatitis (ARD). Some experts think that additional skin hydration can reduce acute skin reactions. Individual radiosensitivity (IRS) determined from lymphocytes may help to...
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MDPI AG
2021-12-01
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| Online Access: | https://www.mdpi.com/2075-1729/12/1/20 |
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| author | Juras Kišonas Jonas Venius Olga Sevriukova Mindaugas Grybauskas Daiva Dabkevičienė Arvydas Burneckis Ričardas Rotomskis |
| author_facet | Juras Kišonas Jonas Venius Olga Sevriukova Mindaugas Grybauskas Daiva Dabkevičienė Arvydas Burneckis Ričardas Rotomskis |
| author_sort | Juras Kišonas |
| collection | DOAJ |
| description | Background: Up to 95% of irradiated patients suffer from ionizing radiation (IR) induced early skin reaction, acute radiation dermatitis (ARD). Some experts think that additional skin hydration can reduce acute skin reactions. Individual radiosensitivity (IRS) determined from lymphocytes may help to predict acute radiation toxicity. The purpose of this study is to evaluate the clinical manifestation of ARD in different skincare groups during whole breast radiotherapy depending on IRS and other risk factors. Methods: A total of 108 early-stage breast cancer patients were randomized into best supportive care (BSC) and additional skincare (ASC) groups. IRS was evaluated using a G2 assay modified with caffeine-induced G2 checkpoint arrest. All patients received a 50 Gy dose to the breast planning target volume (PTV). Clinical assessment of ARD symptoms according to the CTCAE grading scale was performed once a week. Results: IRS was successfully determined for 91 out of 108 patients. A total of 10 patients (11%) had normal IRS, 47 patients (52%) were categorized as radiosensitive, and 34 (37%) as highly radiosensitive. There was no significant difference in the manifestation of ARD between patient groups by skincare or IRS. According to logistic regression, patients with bigger breasts were prone to more severe ARD (<i>p</i> = 0.002). Conclusions: The additional skincare did not improve skin condition during RT. A total of 89% of patients had increased radiosensitivity. IRS determined before RT did not show the predictive value for the manifestation of ARD. Logistic regression revealed that breast volume was the most significant risk factor for the manifestation of ARD. |
| first_indexed | 2024-03-10T01:07:53Z |
| format | Article |
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| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T01:07:53Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-f08b285fc377418d9ea289cab0720e5c2023-11-23T14:23:40ZengMDPI AGLife2075-17292021-12-011212010.3390/life12010020Individual Radiosensitivity as a Risk Factor for the Radiation-Induced Acute RadiodermatitisJuras Kišonas0Jonas Venius1Olga Sevriukova2Mindaugas Grybauskas3Daiva Dabkevičienė4Arvydas Burneckis5Ričardas Rotomskis6Department of Radiation Oncology, National Cancer Institute, LT-08660 Vilnius, LithuaniaMedical Physics Department, National Cancer Institute, LT-08660 Vilnius, LithuaniaRadiation Protection Centre, LT-08352 Vilnius, LithuaniaDepartment of Radiation Oncology, National Cancer Institute, LT-08660 Vilnius, LithuaniaBiobank, National Cancer Institute, LT-08660 Vilnius, LithuaniaDepartment of Radiation Oncology, National Cancer Institute, LT-08660 Vilnius, LithuaniaBiomedical Physics Laboratory, National Cancer Institute, LT-08660 Vilnius, LithuaniaBackground: Up to 95% of irradiated patients suffer from ionizing radiation (IR) induced early skin reaction, acute radiation dermatitis (ARD). Some experts think that additional skin hydration can reduce acute skin reactions. Individual radiosensitivity (IRS) determined from lymphocytes may help to predict acute radiation toxicity. The purpose of this study is to evaluate the clinical manifestation of ARD in different skincare groups during whole breast radiotherapy depending on IRS and other risk factors. Methods: A total of 108 early-stage breast cancer patients were randomized into best supportive care (BSC) and additional skincare (ASC) groups. IRS was evaluated using a G2 assay modified with caffeine-induced G2 checkpoint arrest. All patients received a 50 Gy dose to the breast planning target volume (PTV). Clinical assessment of ARD symptoms according to the CTCAE grading scale was performed once a week. Results: IRS was successfully determined for 91 out of 108 patients. A total of 10 patients (11%) had normal IRS, 47 patients (52%) were categorized as radiosensitive, and 34 (37%) as highly radiosensitive. There was no significant difference in the manifestation of ARD between patient groups by skincare or IRS. According to logistic regression, patients with bigger breasts were prone to more severe ARD (<i>p</i> = 0.002). Conclusions: The additional skincare did not improve skin condition during RT. A total of 89% of patients had increased radiosensitivity. IRS determined before RT did not show the predictive value for the manifestation of ARD. Logistic regression revealed that breast volume was the most significant risk factor for the manifestation of ARD.https://www.mdpi.com/2075-1729/12/1/20individual radiosensitivitybreast cancer radiotherapyacute radiation dermatitisrisk factorsradiation induced skin toxicity |
| spellingShingle | Juras Kišonas Jonas Venius Olga Sevriukova Mindaugas Grybauskas Daiva Dabkevičienė Arvydas Burneckis Ričardas Rotomskis Individual Radiosensitivity as a Risk Factor for the Radiation-Induced Acute Radiodermatitis Life individual radiosensitivity breast cancer radiotherapy acute radiation dermatitis risk factors radiation induced skin toxicity |
| title | Individual Radiosensitivity as a Risk Factor for the Radiation-Induced Acute Radiodermatitis |
| title_full | Individual Radiosensitivity as a Risk Factor for the Radiation-Induced Acute Radiodermatitis |
| title_fullStr | Individual Radiosensitivity as a Risk Factor for the Radiation-Induced Acute Radiodermatitis |
| title_full_unstemmed | Individual Radiosensitivity as a Risk Factor for the Radiation-Induced Acute Radiodermatitis |
| title_short | Individual Radiosensitivity as a Risk Factor for the Radiation-Induced Acute Radiodermatitis |
| title_sort | individual radiosensitivity as a risk factor for the radiation induced acute radiodermatitis |
| topic | individual radiosensitivity breast cancer radiotherapy acute radiation dermatitis risk factors radiation induced skin toxicity |
| url | https://www.mdpi.com/2075-1729/12/1/20 |
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