Increased Immunity against the Oral Germs <i>Porphyromonas gingivalis</i> and <i>Prevotella intermedia</i> in Different Categories of Juvenile Idiopathic Arthritis
(1) Background: The link between periodontal disease and rheumatoid arthritis (RA) is now widely reported. Several studies suggest the role of <i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>) in the pathophysiology of RA and some observations highlight the improvement o...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/10/2613 |
| _version_ | 1827651419370422272 |
|---|---|
| author | Franck Zekre Rolando Cimaz Mireille Paul Teresa Giani Louis Waeckel Anne-Emmanuelle Berger Jean-Louis Stephan Myriam Normand Stéphane Paul Hubert Marotte |
| author_facet | Franck Zekre Rolando Cimaz Mireille Paul Teresa Giani Louis Waeckel Anne-Emmanuelle Berger Jean-Louis Stephan Myriam Normand Stéphane Paul Hubert Marotte |
| author_sort | Franck Zekre |
| collection | DOAJ |
| description | (1) Background: The link between periodontal disease and rheumatoid arthritis (RA) is now widely reported. Several studies suggest the role of <i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>) in the pathophysiology of RA and some observations highlight the improvement of the disease activity induced by therapies against <i>P. gingivalis</i>. We have very little data on the prevalence of <i>P. gingivalis</i> carriage in patients with juvenile idiopathic arthritis (JIA) and its possible involvement in the pathophysiology of inflammatory joint diseases in children. (2) Methods: The specific IgG responses against <i>P. gingivalis</i> and <i>Prevotella intermedia</i> (<i>P. intermedia</i>) were determined in a cohort of 101 patients with JIA and 19 patients with other autoimmune diseases (inflammatory bowel disease and type 1 diabetes). (3) Results: Specific anti-<i>P. gingivalis</i> and anti-<i>P. intermedia</i> IgG titers were higher in JIA group than in control groups. These differences were mainly observed in the oligoarthritis group. The same pattern was observed in enthesitis-related arthritis (ERA). (4) Conclusions: Children with oligoarticular and ERA subsets had higher IgG titers to <i>P. gingivalis</i> and <i>P. intermedia</i>. These results suggest involvement of an oral dysbiosis in the occurrence of JIA in these subgroups. |
| first_indexed | 2024-03-09T20:38:26Z |
| format | Article |
| id | doaj.art-f08d0aed9d7148cea983921e87c9e4a3 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:38:26Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-f08d0aed9d7148cea983921e87c9e4a32023-11-23T23:05:57ZengMDPI AGBiomedicines2227-90592022-10-011010261310.3390/biomedicines10102613Increased Immunity against the Oral Germs <i>Porphyromonas gingivalis</i> and <i>Prevotella intermedia</i> in Different Categories of Juvenile Idiopathic ArthritisFranck Zekre0Rolando Cimaz1Mireille Paul2Teresa Giani3Louis Waeckel4Anne-Emmanuelle Berger5Jean-Louis Stephan6Myriam Normand7Stéphane Paul8Hubert Marotte9LBTO Team, INSERM, 1059, SAINBIOSE (SAnté INgéniérie BIOlogie St-Etienne), Université Jean Monnet, 42055 Saint-Etienne, FranceDepartment of Clinical Sciences and Community Health, University of Milano, 20122 Milano, ItalyLBTO Team, INSERM, 1059, SAINBIOSE (SAnté INgéniérie BIOlogie St-Etienne), Université Jean Monnet, 42055 Saint-Etienne, FranceDepartment of Medical Biotechnology, University of Siena, 53100 Siena, ItalyCIRI (Centre International de Recherche en Infectiologie), Équipe GIMAP (Team 15), INSERM U1111, CNRS, ENS, UCBL1, Université Jean Monnet, Université de Lyon, 42055 Saint-Etienne, FranceLaboratoire d’Immunologie, Hôpital Nord, University Hospital Saint-Etienne, 42055 Saint-Etienne, FranceDepartment of Pediatric, Hôpital Nord, University Hospital Saint-Etienne, 42055 Saint-Etienne, FranceLBTO Team, INSERM, 1059, SAINBIOSE (SAnté INgéniérie BIOlogie St-Etienne), Université Jean Monnet, 42055 Saint-Etienne, FranceCIRI (Centre International de Recherche en Infectiologie), Équipe GIMAP (Team 15), INSERM U1111, CNRS, ENS, UCBL1, Université Jean Monnet, Université de Lyon, 42055 Saint-Etienne, FranceLBTO Team, INSERM, 1059, SAINBIOSE (SAnté INgéniérie BIOlogie St-Etienne), Université Jean Monnet, 42055 Saint-Etienne, France(1) Background: The link between periodontal disease and rheumatoid arthritis (RA) is now widely reported. Several studies suggest the role of <i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>) in the pathophysiology of RA and some observations highlight the improvement of the disease activity induced by therapies against <i>P. gingivalis</i>. We have very little data on the prevalence of <i>P. gingivalis</i> carriage in patients with juvenile idiopathic arthritis (JIA) and its possible involvement in the pathophysiology of inflammatory joint diseases in children. (2) Methods: The specific IgG responses against <i>P. gingivalis</i> and <i>Prevotella intermedia</i> (<i>P. intermedia</i>) were determined in a cohort of 101 patients with JIA and 19 patients with other autoimmune diseases (inflammatory bowel disease and type 1 diabetes). (3) Results: Specific anti-<i>P. gingivalis</i> and anti-<i>P. intermedia</i> IgG titers were higher in JIA group than in control groups. These differences were mainly observed in the oligoarthritis group. The same pattern was observed in enthesitis-related arthritis (ERA). (4) Conclusions: Children with oligoarticular and ERA subsets had higher IgG titers to <i>P. gingivalis</i> and <i>P. intermedia</i>. These results suggest involvement of an oral dysbiosis in the occurrence of JIA in these subgroups.https://www.mdpi.com/2227-9059/10/10/2613juvenile idiopathic arthritisoligoarthritisenthesis related arthritisanti-<i>Porphyromonas gingivalis</i> antibodyanti-<i>Prevotella intermedia</i> antibody |
| spellingShingle | Franck Zekre Rolando Cimaz Mireille Paul Teresa Giani Louis Waeckel Anne-Emmanuelle Berger Jean-Louis Stephan Myriam Normand Stéphane Paul Hubert Marotte Increased Immunity against the Oral Germs <i>Porphyromonas gingivalis</i> and <i>Prevotella intermedia</i> in Different Categories of Juvenile Idiopathic Arthritis Biomedicines juvenile idiopathic arthritis oligoarthritis enthesis related arthritis anti-<i>Porphyromonas gingivalis</i> antibody anti-<i>Prevotella intermedia</i> antibody |
| title | Increased Immunity against the Oral Germs <i>Porphyromonas gingivalis</i> and <i>Prevotella intermedia</i> in Different Categories of Juvenile Idiopathic Arthritis |
| title_full | Increased Immunity against the Oral Germs <i>Porphyromonas gingivalis</i> and <i>Prevotella intermedia</i> in Different Categories of Juvenile Idiopathic Arthritis |
| title_fullStr | Increased Immunity against the Oral Germs <i>Porphyromonas gingivalis</i> and <i>Prevotella intermedia</i> in Different Categories of Juvenile Idiopathic Arthritis |
| title_full_unstemmed | Increased Immunity against the Oral Germs <i>Porphyromonas gingivalis</i> and <i>Prevotella intermedia</i> in Different Categories of Juvenile Idiopathic Arthritis |
| title_short | Increased Immunity against the Oral Germs <i>Porphyromonas gingivalis</i> and <i>Prevotella intermedia</i> in Different Categories of Juvenile Idiopathic Arthritis |
| title_sort | increased immunity against the oral germs i porphyromonas gingivalis i and i prevotella intermedia i in different categories of juvenile idiopathic arthritis |
| topic | juvenile idiopathic arthritis oligoarthritis enthesis related arthritis anti-<i>Porphyromonas gingivalis</i> antibody anti-<i>Prevotella intermedia</i> antibody |
| url | https://www.mdpi.com/2227-9059/10/10/2613 |
| work_keys_str_mv | AT franckzekre increasedimmunityagainsttheoralgermsiporphyromonasgingivalisiandiprevotellaintermediaiindifferentcategoriesofjuvenileidiopathicarthritis AT rolandocimaz increasedimmunityagainsttheoralgermsiporphyromonasgingivalisiandiprevotellaintermediaiindifferentcategoriesofjuvenileidiopathicarthritis AT mireillepaul increasedimmunityagainsttheoralgermsiporphyromonasgingivalisiandiprevotellaintermediaiindifferentcategoriesofjuvenileidiopathicarthritis AT teresagiani increasedimmunityagainsttheoralgermsiporphyromonasgingivalisiandiprevotellaintermediaiindifferentcategoriesofjuvenileidiopathicarthritis AT louiswaeckel increasedimmunityagainsttheoralgermsiporphyromonasgingivalisiandiprevotellaintermediaiindifferentcategoriesofjuvenileidiopathicarthritis AT anneemmanuelleberger increasedimmunityagainsttheoralgermsiporphyromonasgingivalisiandiprevotellaintermediaiindifferentcategoriesofjuvenileidiopathicarthritis AT jeanlouisstephan increasedimmunityagainsttheoralgermsiporphyromonasgingivalisiandiprevotellaintermediaiindifferentcategoriesofjuvenileidiopathicarthritis AT myriamnormand increasedimmunityagainsttheoralgermsiporphyromonasgingivalisiandiprevotellaintermediaiindifferentcategoriesofjuvenileidiopathicarthritis AT stephanepaul increasedimmunityagainsttheoralgermsiporphyromonasgingivalisiandiprevotellaintermediaiindifferentcategoriesofjuvenileidiopathicarthritis AT hubertmarotte increasedimmunityagainsttheoralgermsiporphyromonasgingivalisiandiprevotellaintermediaiindifferentcategoriesofjuvenileidiopathicarthritis |