Genotoxicity of Graphene-Based Materials
Graphene-based materials (GBMs) are a broad family of novel carbon-based nanomaterials with many nanotechnology applications. The increasing market of GBMs raises concerns on their possible impact on human health. Here, we review the existing literature on the genotoxic potential of GBMs over the la...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/11/1795 |
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| author | Josefa Domenech Adriana Rodríguez-Garraus Adela López de Cerain Amaya Azqueta Julia Catalán |
| author_facet | Josefa Domenech Adriana Rodríguez-Garraus Adela López de Cerain Amaya Azqueta Julia Catalán |
| author_sort | Josefa Domenech |
| collection | DOAJ |
| description | Graphene-based materials (GBMs) are a broad family of novel carbon-based nanomaterials with many nanotechnology applications. The increasing market of GBMs raises concerns on their possible impact on human health. Here, we review the existing literature on the genotoxic potential of GBMs over the last ten years. A total of 50 articles including in vitro, in vivo, in silico, and human biomonitoring studies were selected. Graphene oxides were the most analyzed materials, followed by reduced graphene oxides. Most of the evaluations were performed in vitro using the comet assay (detecting DNA damage). The micronucleus assay (detecting chromosome damage) was the most used validated assay, whereas only two publications reported results on mammalian gene mutations. The same material was rarely assessed with more than one assay. Despite inhalation being the main exposure route in occupational settings, only one in vivo study used intratracheal instillation, and another one reported human biomonitoring data. Based on the studies, some GBMs have the potential to induce genetic damage, although the type of damage depends on the material. The broad variability of GBMs, cellular systems and methods used in the studies precludes the identification of physico-chemical properties that could drive the genotoxicity response to GBMs. |
| first_indexed | 2024-03-10T01:03:02Z |
| format | Article |
| id | doaj.art-f0910bd9485447f08dcb8d3066458d38 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T01:03:02Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-f0910bd9485447f08dcb8d3066458d382023-11-23T14:32:23ZengMDPI AGNanomaterials2079-49912022-05-011211179510.3390/nano12111795Genotoxicity of Graphene-Based MaterialsJosefa Domenech0Adriana Rodríguez-Garraus1Adela López de Cerain2Amaya Azqueta3Julia Catalán4Finnish Institute of Occupational Health, Box 40, Työterveyslaitos, 00032 Helsinki, FinlandFinnish Institute of Occupational Health, Box 40, Työterveyslaitos, 00032 Helsinki, FinlandDepartment of Pharmacology and Toxicology, Faculty of Pharmacy and Nutrition, Universidad de Navarra, Irunlarrea 1, 31008 Pamplona, SpainDepartment of Pharmacology and Toxicology, Faculty of Pharmacy and Nutrition, Universidad de Navarra, Irunlarrea 1, 31008 Pamplona, SpainFinnish Institute of Occupational Health, Box 40, Työterveyslaitos, 00032 Helsinki, FinlandGraphene-based materials (GBMs) are a broad family of novel carbon-based nanomaterials with many nanotechnology applications. The increasing market of GBMs raises concerns on their possible impact on human health. Here, we review the existing literature on the genotoxic potential of GBMs over the last ten years. A total of 50 articles including in vitro, in vivo, in silico, and human biomonitoring studies were selected. Graphene oxides were the most analyzed materials, followed by reduced graphene oxides. Most of the evaluations were performed in vitro using the comet assay (detecting DNA damage). The micronucleus assay (detecting chromosome damage) was the most used validated assay, whereas only two publications reported results on mammalian gene mutations. The same material was rarely assessed with more than one assay. Despite inhalation being the main exposure route in occupational settings, only one in vivo study used intratracheal instillation, and another one reported human biomonitoring data. Based on the studies, some GBMs have the potential to induce genetic damage, although the type of damage depends on the material. The broad variability of GBMs, cellular systems and methods used in the studies precludes the identification of physico-chemical properties that could drive the genotoxicity response to GBMs.https://www.mdpi.com/2079-4991/12/11/1795graphene-based materialsgenotoxicitymutagenicity |
| spellingShingle | Josefa Domenech Adriana Rodríguez-Garraus Adela López de Cerain Amaya Azqueta Julia Catalán Genotoxicity of Graphene-Based Materials Nanomaterials graphene-based materials genotoxicity mutagenicity |
| title | Genotoxicity of Graphene-Based Materials |
| title_full | Genotoxicity of Graphene-Based Materials |
| title_fullStr | Genotoxicity of Graphene-Based Materials |
| title_full_unstemmed | Genotoxicity of Graphene-Based Materials |
| title_short | Genotoxicity of Graphene-Based Materials |
| title_sort | genotoxicity of graphene based materials |
| topic | graphene-based materials genotoxicity mutagenicity |
| url | https://www.mdpi.com/2079-4991/12/11/1795 |
| work_keys_str_mv | AT josefadomenech genotoxicityofgraphenebasedmaterials AT adrianarodriguezgarraus genotoxicityofgraphenebasedmaterials AT adelalopezdecerain genotoxicityofgraphenebasedmaterials AT amayaazqueta genotoxicityofgraphenebasedmaterials AT juliacatalan genotoxicityofgraphenebasedmaterials |