Pancreaticobiliary Cancers and Aeromonas Isolates Carrying Type Ⅲ Secretion System Genes ascF-ascG Are Associated With Increased Mortality: An Analysis of 164 Aeromonas Infection Episodes in Southern Taiwan
This prospective study aimed to investigate the clinical and microbiological characteristics of different Aeromonas species. Clinical isolates of Aeromonas species between 2016 to 2018 were collected in a university hospital in southern Taiwan. The species was determined by rpoD or gyrB sequencing....
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.749269/full |
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| author | Ying-Wen Chen Shu-Li Su Chia-Wen Li Chia-Wen Li Chia-Wen Li Chin-Shiang Tsai Chin-Shiang Tsai Ching-Lung Lo Ching-Lung Lo Ling-Shan Syue Ling-Shan Syue Min-Chi Li Min-Chi Li Min-Chi Li Ching-Chi Lee Ching-Chi Lee Nan-Yao Lee Nan-Yao Lee Nan-Yao Lee Wen-Chien Ko Wen-Chien Ko Wen-Chien Ko Po-Lin Chen Po-Lin Chen Po-Lin Chen |
| author_facet | Ying-Wen Chen Shu-Li Su Chia-Wen Li Chia-Wen Li Chia-Wen Li Chin-Shiang Tsai Chin-Shiang Tsai Ching-Lung Lo Ching-Lung Lo Ling-Shan Syue Ling-Shan Syue Min-Chi Li Min-Chi Li Min-Chi Li Ching-Chi Lee Ching-Chi Lee Nan-Yao Lee Nan-Yao Lee Nan-Yao Lee Wen-Chien Ko Wen-Chien Ko Wen-Chien Ko Po-Lin Chen Po-Lin Chen Po-Lin Chen |
| author_sort | Ying-Wen Chen |
| collection | DOAJ |
| description | This prospective study aimed to investigate the clinical and microbiological characteristics of different Aeromonas species. Clinical isolates of Aeromonas species between 2016 to 2018 were collected in a university hospital in southern Taiwan. The species was determined by rpoD or gyrB sequencing. A total of 222 Aeromonas isolates from 160 patients in 164 episodes were identified. The crude in-hospital mortality was 17.2%. The most frequently isolated species was Aeromonas veronii (30.6%), followed by A. caviae (24.8%), A. hydrophila (23%), and A. dhakensis (16.7%). The major clinical manifestations were primary bacteremia (31.1%), skin and soft tissue infection (22.6%), and biliary tract infection (18.3%). The most common underlying diseases were malignancy (45.1%), diabetes mellitus (27.4%), and liver cirrhosis or chronic hepatitis (26.2%). A. hydrophila and A. dhakensis predominated in the skin and soft tissue infection (p<0.0001), whereas A. vernoii and A. caviae prevailed in primary bacteremia and biliary tract infections (p=0.012). Pneumonia, malignancy, and ascF-ascG genotype were independent factors associated with mortality. Ertapenem susceptibility was decreased in A. sobria (42.9%), A. veronii (66.7%), A. dhakensis (73%), and A. hydrophila (84.3%). Cefotaxime resistance was found in 30.9% of A. caviae and 18.9% of A. dhakensis isolates, much more prevalent than the other species. The metallo-β-lactamase blaCphA was almost invariably present in A. dhakensis, A. hydrophila, and A. veronii (100%, 100% and 89.9%, respectively). Amp-C β-lactamases such as blaMOX and blaAQU-1 were identified in all A. caviae and 91.9% of A. dhakensis isolates. Cefepime, fluoroquinolones and tigecycline showed good in vitro activity against aeromonads. |
| first_indexed | 2024-12-19T17:32:56Z |
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| id | doaj.art-f091b4cddc3e4fc09eaa667f0692e928 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-19T17:32:56Z |
| publishDate | 2021-10-01 |
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| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-f091b4cddc3e4fc09eaa667f0692e9282022-12-21T20:12:24ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-10-011110.3389/fcimb.2021.749269749269Pancreaticobiliary Cancers and Aeromonas Isolates Carrying Type Ⅲ Secretion System Genes ascF-ascG Are Associated With Increased Mortality: An Analysis of 164 Aeromonas Infection Episodes in Southern TaiwanYing-Wen Chen0Shu-Li Su1Chia-Wen Li2Chia-Wen Li3Chia-Wen Li4Chin-Shiang Tsai5Chin-Shiang Tsai6Ching-Lung Lo7Ching-Lung Lo8Ling-Shan Syue9Ling-Shan Syue10Min-Chi Li11Min-Chi Li12Min-Chi Li13Ching-Chi Lee14Ching-Chi Lee15Nan-Yao Lee16Nan-Yao Lee17Nan-Yao Lee18Wen-Chien Ko19Wen-Chien Ko20Wen-Chien Ko21Po-Lin Chen22Po-Lin Chen23Po-Lin Chen24Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDiagnostic Microbiology and Antimicrobial Resistance Laboratory, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanInfection Control Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Medicine, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanInfection Control Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanInfection Control Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanInfection Control Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanInfection Control Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Medicine, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanClinical Medicine Research Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanInfection Control Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Medicine, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanInfection Control Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Medicine, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanInfection Control Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, TaiwanThis prospective study aimed to investigate the clinical and microbiological characteristics of different Aeromonas species. Clinical isolates of Aeromonas species between 2016 to 2018 were collected in a university hospital in southern Taiwan. The species was determined by rpoD or gyrB sequencing. A total of 222 Aeromonas isolates from 160 patients in 164 episodes were identified. The crude in-hospital mortality was 17.2%. The most frequently isolated species was Aeromonas veronii (30.6%), followed by A. caviae (24.8%), A. hydrophila (23%), and A. dhakensis (16.7%). The major clinical manifestations were primary bacteremia (31.1%), skin and soft tissue infection (22.6%), and biliary tract infection (18.3%). The most common underlying diseases were malignancy (45.1%), diabetes mellitus (27.4%), and liver cirrhosis or chronic hepatitis (26.2%). A. hydrophila and A. dhakensis predominated in the skin and soft tissue infection (p<0.0001), whereas A. vernoii and A. caviae prevailed in primary bacteremia and biliary tract infections (p=0.012). Pneumonia, malignancy, and ascF-ascG genotype were independent factors associated with mortality. Ertapenem susceptibility was decreased in A. sobria (42.9%), A. veronii (66.7%), A. dhakensis (73%), and A. hydrophila (84.3%). Cefotaxime resistance was found in 30.9% of A. caviae and 18.9% of A. dhakensis isolates, much more prevalent than the other species. The metallo-β-lactamase blaCphA was almost invariably present in A. dhakensis, A. hydrophila, and A. veronii (100%, 100% and 89.9%, respectively). Amp-C β-lactamases such as blaMOX and blaAQU-1 were identified in all A. caviae and 91.9% of A. dhakensis isolates. Cefepime, fluoroquinolones and tigecycline showed good in vitro activity against aeromonads.https://www.frontiersin.org/articles/10.3389/fcimb.2021.749269/fullAeromonasidentificationrpoD sequencingascF-ascGtype 3 secretion systemantimicrobial resistance |
| spellingShingle | Ying-Wen Chen Shu-Li Su Chia-Wen Li Chia-Wen Li Chia-Wen Li Chin-Shiang Tsai Chin-Shiang Tsai Ching-Lung Lo Ching-Lung Lo Ling-Shan Syue Ling-Shan Syue Min-Chi Li Min-Chi Li Min-Chi Li Ching-Chi Lee Ching-Chi Lee Nan-Yao Lee Nan-Yao Lee Nan-Yao Lee Wen-Chien Ko Wen-Chien Ko Wen-Chien Ko Po-Lin Chen Po-Lin Chen Po-Lin Chen Pancreaticobiliary Cancers and Aeromonas Isolates Carrying Type Ⅲ Secretion System Genes ascF-ascG Are Associated With Increased Mortality: An Analysis of 164 Aeromonas Infection Episodes in Southern Taiwan Frontiers in Cellular and Infection Microbiology Aeromonas identification rpoD sequencing ascF-ascG type 3 secretion system antimicrobial resistance |
| title | Pancreaticobiliary Cancers and Aeromonas Isolates Carrying Type Ⅲ Secretion System Genes ascF-ascG Are Associated With Increased Mortality: An Analysis of 164 Aeromonas Infection Episodes in Southern Taiwan |
| title_full | Pancreaticobiliary Cancers and Aeromonas Isolates Carrying Type Ⅲ Secretion System Genes ascF-ascG Are Associated With Increased Mortality: An Analysis of 164 Aeromonas Infection Episodes in Southern Taiwan |
| title_fullStr | Pancreaticobiliary Cancers and Aeromonas Isolates Carrying Type Ⅲ Secretion System Genes ascF-ascG Are Associated With Increased Mortality: An Analysis of 164 Aeromonas Infection Episodes in Southern Taiwan |
| title_full_unstemmed | Pancreaticobiliary Cancers and Aeromonas Isolates Carrying Type Ⅲ Secretion System Genes ascF-ascG Are Associated With Increased Mortality: An Analysis of 164 Aeromonas Infection Episodes in Southern Taiwan |
| title_short | Pancreaticobiliary Cancers and Aeromonas Isolates Carrying Type Ⅲ Secretion System Genes ascF-ascG Are Associated With Increased Mortality: An Analysis of 164 Aeromonas Infection Episodes in Southern Taiwan |
| title_sort | pancreaticobiliary cancers and aeromonas isolates carrying type iii secretion system genes ascf ascg are associated with increased mortality an analysis of 164 aeromonas infection episodes in southern taiwan |
| topic | Aeromonas identification rpoD sequencing ascF-ascG type 3 secretion system antimicrobial resistance |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.749269/full |
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