Cognitive Impairments in Multiple System Atrophy of the Cerebellar Type
Background and Purpose We investigated the cognitive profiles in a large sample of patients with multiple system atrophy-cerebellar ataxia (MSA-C) and compared directly them in patients with clinical diagnosis of probable MSA-C without dementia and control subjects with intact cognition. Methods We...
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Format: | Article |
Language: | English |
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Korean Movement Disorder Society
2011-05-01
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Series: | Journal of Movement Disorders |
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Online Access: | http://e-jmd.org/upload/jmd-4-1-41-7.pdf |
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author | Hyun J. Hong Sook Keun. Song Phil Hyu Lee Young Ho Sohn Ji E. Lee |
author_facet | Hyun J. Hong Sook Keun. Song Phil Hyu Lee Young Ho Sohn Ji E. Lee |
author_sort | Hyun J. Hong |
collection | DOAJ |
description | Background and Purpose We investigated the cognitive profiles in a large sample of patients with multiple system atrophy-cerebellar ataxia (MSA-C) and compared directly them in patients with clinical diagnosis of probable MSA-C without dementia and control subjects with intact cognition. Methods We prospectively enrolled 26 patients with clinical diagnosis of probable MSA-C. All patients underwent a standardized neuropsychological test of the Seoul Neuropsychological Screening Battery. Results The score of Korean version of the Mini- Mental State Examination was significantly lower in patients with MSA-C (27.2 ± 2.5) than in control subjects (28.9 ± 1.0, p = 0.003). Patients with MSA-C showed a significantly worse performance in visuospatial function, 3 words recall, verbal immediate, delayed and recognition memory, visual delayed memory, phonemic and sementic Controlled Oral Word Association Test, and ideomotor praxis (p < 0.05). Conclusions Patients with MSA-C show more severe and more widespread cognitive dysfunctions than controls. Our results also indicate that cognitive dysfunction in patients with MCA-C is suggestive of disruption of the cerebellocortical circuits. |
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format | Article |
id | doaj.art-f091e2175cb5455aa7a817fbb1ecd3b3 |
institution | Directory Open Access Journal |
issn | 2005-940X 2093-4939 |
language | English |
last_indexed | 2024-03-12T08:16:19Z |
publishDate | 2011-05-01 |
publisher | Korean Movement Disorder Society |
record_format | Article |
series | Journal of Movement Disorders |
spelling | doaj.art-f091e2175cb5455aa7a817fbb1ecd3b32023-09-02T18:56:15ZengKorean Movement Disorder SocietyJournal of Movement Disorders2005-940X2093-49392011-05-0141414510.14802/jmd.1100732Cognitive Impairments in Multiple System Atrophy of the Cerebellar TypeHyun J. HongSook Keun. SongPhil Hyu LeeYoung Ho SohnJi E. LeeBackground and Purpose We investigated the cognitive profiles in a large sample of patients with multiple system atrophy-cerebellar ataxia (MSA-C) and compared directly them in patients with clinical diagnosis of probable MSA-C without dementia and control subjects with intact cognition. Methods We prospectively enrolled 26 patients with clinical diagnosis of probable MSA-C. All patients underwent a standardized neuropsychological test of the Seoul Neuropsychological Screening Battery. Results The score of Korean version of the Mini- Mental State Examination was significantly lower in patients with MSA-C (27.2 ± 2.5) than in control subjects (28.9 ± 1.0, p = 0.003). Patients with MSA-C showed a significantly worse performance in visuospatial function, 3 words recall, verbal immediate, delayed and recognition memory, visual delayed memory, phonemic and sementic Controlled Oral Word Association Test, and ideomotor praxis (p < 0.05). Conclusions Patients with MSA-C show more severe and more widespread cognitive dysfunctions than controls. Our results also indicate that cognitive dysfunction in patients with MCA-C is suggestive of disruption of the cerebellocortical circuits.http://e-jmd.org/upload/jmd-4-1-41-7.pdfMultiple system atrophy |
spellingShingle | Hyun J. Hong Sook Keun. Song Phil Hyu Lee Young Ho Sohn Ji E. Lee Cognitive Impairments in Multiple System Atrophy of the Cerebellar Type Journal of Movement Disorders Multiple system atrophy |
title | Cognitive Impairments in Multiple System Atrophy of the Cerebellar Type |
title_full | Cognitive Impairments in Multiple System Atrophy of the Cerebellar Type |
title_fullStr | Cognitive Impairments in Multiple System Atrophy of the Cerebellar Type |
title_full_unstemmed | Cognitive Impairments in Multiple System Atrophy of the Cerebellar Type |
title_short | Cognitive Impairments in Multiple System Atrophy of the Cerebellar Type |
title_sort | cognitive impairments in multiple system atrophy of the cerebellar type |
topic | Multiple system atrophy |
url | http://e-jmd.org/upload/jmd-4-1-41-7.pdf |
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