Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia

Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia

Abstract Stem cell memory T (TSCM) and central memory T (TCM) cells can rapidly differentiate into effector memory (TEM) and terminal effector (TEF) T cells, and have the most potential for immunotherapy. In this study, we found that the frequency of TSCM and TCM cells in the CD8+ population dramati...

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Bibliographic Details
Main Authors: Ling Xu, Danlin Yao, Jiaxiong Tan, Zifan He, Zhi Yu, Jie Chen, Gengxin Luo, Chunli Wang, Fenfang Zhou, Xianfeng Zha, Shaohua Chen, Yangqiu Li
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Hematology & Oncology
Subjects:
Stem cell memory T cells
Central memory T cells
Effector memory T cells
CD8+ T cells
Acute myeloid leukemia
Bone marrow
Online Access:http://link.springer.com/article/10.1186/s13045-018-0636-y
Description
Summary:Abstract Stem cell memory T (TSCM) and central memory T (TCM) cells can rapidly differentiate into effector memory (TEM) and terminal effector (TEF) T cells, and have the most potential for immunotherapy. In this study, we found that the frequency of TSCM and TCM cells in the CD8+ population dramatically decreased together with increases in TEM and TEF cells, particularly in younger patients with acute myeloid leukemia (AML) (< 60 years). These alterations persisted in patients who achieved complete remission after chemotherapy. The decrease in TSCM and TCM together with the increase in differentiated TEM and TEF subsets in CD8+ T cells may explain the reduced T cell response and subdued anti-leukemia capacity in AML patients.
ISSN:1756-8722

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