Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto-Kakizaki rats

Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto-Kakizaki rats

We previously reported that the type 2 diabetic Goto-Kakizaki (GK) rats at young adult ages (6-12 weeks) exhibited increased visceral fat mass and hyperleptinemia, due to hyperphagia caused primarily by neuropeptide Y (NPY) overexpression in the hypothalamic arcuate nucleus. Later, we found that GK...

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Bibliographic Details
Main Authors: Fumihiko eMaekawa, Ken eFujiwara, Masako eToriya, Yuko eMaejima, Takashi eNishio, Yukiyasu eToyoda, Keiko eNohara, Takashi eYashiro, Toshihiko eYada
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Adiposity
Glucose
BDNF
type 2 diabetes
visceral fat
VMH
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsyn.2013.00007/full

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