Genetics of COVID‐19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review
Abstract COVID‐19 and ME/CFS present with some similar symptoms, especially physical and mental fatigue. In order to understand the basis of these similarities and the possibility of underlying common genetic components, we performed a systematic review of all published genetic association and cohor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51631 |
| _version_ | 1798022752828915712 |
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| author | Maria Tziastoudi Christos Cholevas Ioannis Stefanidis Theoharis C. Theoharides |
| author_facet | Maria Tziastoudi Christos Cholevas Ioannis Stefanidis Theoharis C. Theoharides |
| author_sort | Maria Tziastoudi |
| collection | DOAJ |
| description | Abstract COVID‐19 and ME/CFS present with some similar symptoms, especially physical and mental fatigue. In order to understand the basis of these similarities and the possibility of underlying common genetic components, we performed a systematic review of all published genetic association and cohort studies regarding COVID‐19 and ME/CFS and extracted the genes along with the genetic variants investigated. We then performed gene ontology and pathway analysis of those genes that gave significant results in the individual studies to yield functional annotations of the studied genes using protein analysis through evolutionary relationships (PANTHER) VERSION 17.0 software. Finally, we identified the common genetic components of these two conditions. Seventy‐one studies for COVID‐19 and 26 studies for ME/CFS were included in the systematic review in which the expression of 97 genes for COVID‐19 and 429 genes for ME/CFS were significantly affected. We found that ACE, HLA‐A, HLA‐C, HLA‐DQA1, HLA‐DRB1, and TYK2 are the common genes that gave significant results. The findings of the pathway analysis highlight the contribution of inflammation mediated by chemokine and cytokine signaling pathways, and the T cell activation and Toll receptor signaling pathways. Protein class analysis revealed the contribution of defense/immunity proteins, as well as protein‐modifying enzymes. Our results suggest that the pathogenesis of both syndromes could involve some immune dysfunction. |
| first_indexed | 2024-04-11T17:35:07Z |
| format | Article |
| id | doaj.art-f09441ce8a6a49de91c9f157eed4ef17 |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-04-11T17:35:07Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-f09441ce8a6a49de91c9f157eed4ef172022-12-22T04:11:40ZengWileyAnnals of Clinical and Translational Neurology2328-95032022-11-019111838185710.1002/acn3.51631Genetics of COVID‐19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic reviewMaria Tziastoudi0Christos Cholevas1Ioannis Stefanidis2Theoharis C. Theoharides3Department of Nephrology, Faculty of Medicine, School of Health Sciences University of Thessaly Larissa GreeceFirst Department of Ophthalmology, Faculty of Health Sciences Aristotle University, AHEPA Hospital Thessaloniki GreeceDepartment of Nephrology, Faculty of Medicine, School of Health Sciences University of Thessaly Larissa GreeceInstitute of Neuro-Immune Medicine Nova Southeastern University Clearwater FL USAAbstract COVID‐19 and ME/CFS present with some similar symptoms, especially physical and mental fatigue. In order to understand the basis of these similarities and the possibility of underlying common genetic components, we performed a systematic review of all published genetic association and cohort studies regarding COVID‐19 and ME/CFS and extracted the genes along with the genetic variants investigated. We then performed gene ontology and pathway analysis of those genes that gave significant results in the individual studies to yield functional annotations of the studied genes using protein analysis through evolutionary relationships (PANTHER) VERSION 17.0 software. Finally, we identified the common genetic components of these two conditions. Seventy‐one studies for COVID‐19 and 26 studies for ME/CFS were included in the systematic review in which the expression of 97 genes for COVID‐19 and 429 genes for ME/CFS were significantly affected. We found that ACE, HLA‐A, HLA‐C, HLA‐DQA1, HLA‐DRB1, and TYK2 are the common genes that gave significant results. The findings of the pathway analysis highlight the contribution of inflammation mediated by chemokine and cytokine signaling pathways, and the T cell activation and Toll receptor signaling pathways. Protein class analysis revealed the contribution of defense/immunity proteins, as well as protein‐modifying enzymes. Our results suggest that the pathogenesis of both syndromes could involve some immune dysfunction.https://doi.org/10.1002/acn3.51631 |
| spellingShingle | Maria Tziastoudi Christos Cholevas Ioannis Stefanidis Theoharis C. Theoharides Genetics of COVID‐19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review Annals of Clinical and Translational Neurology |
| title | Genetics of COVID‐19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review |
| title_full | Genetics of COVID‐19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review |
| title_fullStr | Genetics of COVID‐19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review |
| title_full_unstemmed | Genetics of COVID‐19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review |
| title_short | Genetics of COVID‐19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review |
| title_sort | genetics of covid 19 and myalgic encephalomyelitis chronic fatigue syndrome a systematic review |
| url | https://doi.org/10.1002/acn3.51631 |
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