Factors Associated With Delayed and Late Initiation of Antiretroviral Therapy Among Patients With HIV in Beijing, China, 2010–2020
Objectives: To determine factors associated with late and delayed antiretroviral therapy (ART) initiation in China and provide evidence for HIV prevention.Methods: Logistics regression model was used to determine factors associated with three outcomes: late (CD4 cell count <200 cells/µL or cl...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | International Journal of Public Health |
| Subjects: | |
| Online Access: | https://www.ssph-journal.org/articles/10.3389/ijph.2023.1605824/full |
| _version_ | 1797798241437220864 |
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| author | Yuanqi Mi Mengge Zhou Mengge Zhou Yuhong Zeng Peicheng Wang Liangmin Gao Feng Cheng |
| author_facet | Yuanqi Mi Mengge Zhou Mengge Zhou Yuhong Zeng Peicheng Wang Liangmin Gao Feng Cheng |
| author_sort | Yuanqi Mi |
| collection | DOAJ |
| description | Objectives: To determine factors associated with late and delayed antiretroviral therapy (ART) initiation in China and provide evidence for HIV prevention.Methods: Logistics regression model was used to determine factors associated with three outcomes: late (CD4 cell count <200 cells/µL or clinical AIDS diagnosis prior to ART initiation), delayed (more than 1 month between HIV diagnosis date and ART initiation) and either late or delayed ART initiation.Results: Multivariable analysis revealed that male, heterosexual, HIV diagnosis before 2014, HBV/HCV seropositive, and tuberculosis were associated with increased odds of all three outcomes. Conversely, married or cohabiting patients were less likely to have delayed ART initiation and either late or delayed ART initiation, while people who inject drugs were more likely to have these two outcomes. Additionally, older age was associated with an increased risk of having either late or delayed ART initiation, but a decreased risk of delayed ART initiation.Conclusion: The proportion of late and delayed ART initiation decreased significantly after the release of the 2016 guidelines in China. To further improve late diagnosis and early treatment, precise interventions for key populations are required. |
| first_indexed | 2024-03-13T04:00:34Z |
| format | Article |
| id | doaj.art-f094e9abca604505bd40c38858c197e2 |
| institution | Directory Open Access Journal |
| issn | 1661-8564 |
| language | English |
| last_indexed | 2024-03-13T04:00:34Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | International Journal of Public Health |
| spelling | doaj.art-f094e9abca604505bd40c38858c197e22023-06-21T16:48:37ZengFrontiers Media S.A.International Journal of Public Health1661-85642023-06-016810.3389/ijph.2023.16058241605824Factors Associated With Delayed and Late Initiation of Antiretroviral Therapy Among Patients With HIV in Beijing, China, 2010–2020Yuanqi Mi0Mengge Zhou1Mengge Zhou2Yuhong Zeng3Peicheng Wang4Liangmin Gao5Feng Cheng6Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United StatesDepartment of Epidemiology and Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Epidemiology and Biostatistics, School of Basic Medicine, Peking Union Medical College, Beijing, ChinaDepartment of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, ChinaVanke School of Public Health, Tsinghua University, Beijing, ChinaInstitute for International and Areas Studies, Tsinghua University, Beijing, ChinaVanke School of Public Health, Tsinghua University, Beijing, ChinaObjectives: To determine factors associated with late and delayed antiretroviral therapy (ART) initiation in China and provide evidence for HIV prevention.Methods: Logistics regression model was used to determine factors associated with three outcomes: late (CD4 cell count <200 cells/µL or clinical AIDS diagnosis prior to ART initiation), delayed (more than 1 month between HIV diagnosis date and ART initiation) and either late or delayed ART initiation.Results: Multivariable analysis revealed that male, heterosexual, HIV diagnosis before 2014, HBV/HCV seropositive, and tuberculosis were associated with increased odds of all three outcomes. Conversely, married or cohabiting patients were less likely to have delayed ART initiation and either late or delayed ART initiation, while people who inject drugs were more likely to have these two outcomes. Additionally, older age was associated with an increased risk of having either late or delayed ART initiation, but a decreased risk of delayed ART initiation.Conclusion: The proportion of late and delayed ART initiation decreased significantly after the release of the 2016 guidelines in China. To further improve late diagnosis and early treatment, precise interventions for key populations are required.https://www.ssph-journal.org/articles/10.3389/ijph.2023.1605824/fullassociated factorsChinaantiretroviral therapyHIVCD4 |
| spellingShingle | Yuanqi Mi Mengge Zhou Mengge Zhou Yuhong Zeng Peicheng Wang Liangmin Gao Feng Cheng Factors Associated With Delayed and Late Initiation of Antiretroviral Therapy Among Patients With HIV in Beijing, China, 2010–2020 International Journal of Public Health associated factors China antiretroviral therapy HIV CD4 |
| title | Factors Associated With Delayed and Late Initiation of Antiretroviral Therapy Among Patients With HIV in Beijing, China, 2010–2020 |
| title_full | Factors Associated With Delayed and Late Initiation of Antiretroviral Therapy Among Patients With HIV in Beijing, China, 2010–2020 |
| title_fullStr | Factors Associated With Delayed and Late Initiation of Antiretroviral Therapy Among Patients With HIV in Beijing, China, 2010–2020 |
| title_full_unstemmed | Factors Associated With Delayed and Late Initiation of Antiretroviral Therapy Among Patients With HIV in Beijing, China, 2010–2020 |
| title_short | Factors Associated With Delayed and Late Initiation of Antiretroviral Therapy Among Patients With HIV in Beijing, China, 2010–2020 |
| title_sort | factors associated with delayed and late initiation of antiretroviral therapy among patients with hiv in beijing china 2010 2020 |
| topic | associated factors China antiretroviral therapy HIV CD4 |
| url | https://www.ssph-journal.org/articles/10.3389/ijph.2023.1605824/full |
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