LBMPL Vaccine Therapy Induces Progressive Organization of the Spleen Microarchitecture, Improved Th1 Adaptative Immune Response and Control of Parasitism in <i>Leishmania infantum</i> Naturally Infected Dogs

LBMPL Vaccine Therapy Induces Progressive Organization of the Spleen Microarchitecture, Improved Th1 Adaptative Immune Response and Control of Parasitism in <i>Leishmania infantum</i> Naturally Infected Dogs

The spleen plays a central role in human and canine visceral leishmaniasis, where the activation of the immune response occurs in one of the tissues where <i>Leishmania infantum</i> reproduces. Therefore, this organ is both a target to understand the mechanisms involved in the parasite c...

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Bibliographic Details
Main Authors: Bruno Mendes Roatt, Jamille Mirelle de Oliveira Cardoso, Levi Eduardo Soares Reis, Gabriel José Lucas Moreira, Letícia Captein Gonçalves, Flávia de Souza Marques, Nádia das Dores Moreira, Paula Melo de Abreu Vieira, Rodrigo Dian de Oliveira Aguiar-Soares, Rodolfo Cordeiro Giunchetti, Alexandre Barbosa Reis
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pathogens
Subjects:
canine visceral leishmaniasis
<i>Leishmania infantum</i>
immunotherapy
LBMPL vaccine
spleen
Online Access:https://www.mdpi.com/2076-0817/11/9/974

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