Cubosomes-assisted transdermal delivery of doxorubicin and indocyanine green for chemo-photothermal combination therapy of melanoma
Melanoma is a highly aggressive form of skin cancer with limited therapeutic options. Chemo-photothermal combination therapy has demonstrated potential for effectively treating melanoma, and transdermal administration is considered the optimal route for treating skin diseases due to its ability to b...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223011071 |
| _version_ | 1797686900233863168 |
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| author | Zhenzhen Chen Qinbiao Huang Yutong Song Xianquan Feng Lingjun Zeng Zhihong Liu Xiaomu Hu Chun Tao Lie Wang Yafeng Qi Hongtao Song |
| author_facet | Zhenzhen Chen Qinbiao Huang Yutong Song Xianquan Feng Lingjun Zeng Zhihong Liu Xiaomu Hu Chun Tao Lie Wang Yafeng Qi Hongtao Song |
| author_sort | Zhenzhen Chen |
| collection | DOAJ |
| description | Melanoma is a highly aggressive form of skin cancer with limited therapeutic options. Chemo-photothermal combination therapy has demonstrated potential for effectively treating melanoma, and transdermal administration is considered the optimal route for treating skin diseases due to its ability to bypass first-pass metabolism and enhance drug concentration. However, the stratum corneum presents a formidable challenge as a significant barrier to drug penetration in transdermal drug delivery. Lipid-nanocarriers, particularly cubosomes, have been demonstrated to possess significant potential in augmenting drug permeation across the stratum corneum. Herein, cubosomes co-loaded with doxorubicin (DOX, a chemotherapeutic drug) and indocyanine green (ICG, a photothermal agent) (DOX-ICG-cubo) transdermal drug delivery system was developed to enhance the therapeutic efficiency of melanoma by improving drug permeation. The DOX-ICG-cubo showed high encapsulation efficiency of both DOX and ICG, and exhibited good stability under physiological conditions. In addition, the unique cubic structure of the DOX-ICG-cubo was confirmed through transmission electron microscopy (TEM) images, polarizing microscopy, and small angle X-ray scattering (SAXS). The DOX-ICG-cubo presented high photothermal conversion efficiency, as well as pH and thermo-responsive DOX release. Notably, the DOX-ICG-cubo exhibited enhanced drug permeation efficiency, good biocompatibility, and improved in vivo anti-melanoma efficacy through the synergistic effects of chemo-photothermal therapy. In conclusion, DOX-ICG-cubo presented a promising strategy for melanoma treatment. |
| first_indexed | 2024-03-12T01:11:15Z |
| format | Article |
| id | doaj.art-f0967bbfda394b30b08e396342a4d1bb |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T01:11:15Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-f0967bbfda394b30b08e396342a4d1bb2023-09-14T04:52:37ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-10-01166115316Cubosomes-assisted transdermal delivery of doxorubicin and indocyanine green for chemo-photothermal combination therapy of melanomaZhenzhen Chen0Qinbiao Huang1Yutong Song2Xianquan Feng3Lingjun Zeng4Zhihong Liu5Xiaomu Hu6Chun Tao7Lie Wang8Yafeng Qi9Hongtao Song10Department of Pharmacy, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou 350025, PR China; Department of Pharmacy, 900TH Hospital of Joint Logistics Support Force, People’s Liberation Army (PLA), Fuzhou 350025, PR ChinaDepartment of Pharmacy, 900TH Hospital of Joint Logistics Support Force, People’s Liberation Army (PLA), Fuzhou 350025, PR ChinaThe First School of Clinical Medicine, Nanjing Medical University, Nanjing 210029, PR ChinaDepartment of Pharmacy, 900TH Hospital of Joint Logistics Support Force, People’s Liberation Army (PLA), Fuzhou 350025, PR ChinaDepartment of Pharmacy, 900TH Hospital of Joint Logistics Support Force, People’s Liberation Army (PLA), Fuzhou 350025, PR ChinaDepartment of Pharmacy, 900TH Hospital of Joint Logistics Support Force, People’s Liberation Army (PLA), Fuzhou 350025, PR ChinaDepartment of Pharmacy, 900TH Hospital of Joint Logistics Support Force, People’s Liberation Army (PLA), Fuzhou 350025, PR ChinaDepartment of Pharmacy, 900TH Hospital of Joint Logistics Support Force, People’s Liberation Army (PLA), Fuzhou 350025, PR ChinaDepartment of General Surgery, 900TH Hospital of Joint Logistics Support Force, People’s Liberation Army (PLA), Fuzhou 350025, PR ChinaDepartment of General Surgery, 900TH Hospital of Joint Logistics Support Force, People’s Liberation Army (PLA), Fuzhou 350025, PR China; Corresponding authors.Department of Pharmacy, 900TH Hospital of Joint Logistics Support Force, People’s Liberation Army (PLA), Fuzhou 350025, PR China; Corresponding authors.Melanoma is a highly aggressive form of skin cancer with limited therapeutic options. Chemo-photothermal combination therapy has demonstrated potential for effectively treating melanoma, and transdermal administration is considered the optimal route for treating skin diseases due to its ability to bypass first-pass metabolism and enhance drug concentration. However, the stratum corneum presents a formidable challenge as a significant barrier to drug penetration in transdermal drug delivery. Lipid-nanocarriers, particularly cubosomes, have been demonstrated to possess significant potential in augmenting drug permeation across the stratum corneum. Herein, cubosomes co-loaded with doxorubicin (DOX, a chemotherapeutic drug) and indocyanine green (ICG, a photothermal agent) (DOX-ICG-cubo) transdermal drug delivery system was developed to enhance the therapeutic efficiency of melanoma by improving drug permeation. The DOX-ICG-cubo showed high encapsulation efficiency of both DOX and ICG, and exhibited good stability under physiological conditions. In addition, the unique cubic structure of the DOX-ICG-cubo was confirmed through transmission electron microscopy (TEM) images, polarizing microscopy, and small angle X-ray scattering (SAXS). The DOX-ICG-cubo presented high photothermal conversion efficiency, as well as pH and thermo-responsive DOX release. Notably, the DOX-ICG-cubo exhibited enhanced drug permeation efficiency, good biocompatibility, and improved in vivo anti-melanoma efficacy through the synergistic effects of chemo-photothermal therapy. In conclusion, DOX-ICG-cubo presented a promising strategy for melanoma treatment.http://www.sciencedirect.com/science/article/pii/S0753332223011071CubosomesDoxorubicinIndocyanine greenChemo-photothermal combination therapyTransdermal deliveryMelanoma |
| spellingShingle | Zhenzhen Chen Qinbiao Huang Yutong Song Xianquan Feng Lingjun Zeng Zhihong Liu Xiaomu Hu Chun Tao Lie Wang Yafeng Qi Hongtao Song Cubosomes-assisted transdermal delivery of doxorubicin and indocyanine green for chemo-photothermal combination therapy of melanoma Biomedicine & Pharmacotherapy Cubosomes Doxorubicin Indocyanine green Chemo-photothermal combination therapy Transdermal delivery Melanoma |
| title | Cubosomes-assisted transdermal delivery of doxorubicin and indocyanine green for chemo-photothermal combination therapy of melanoma |
| title_full | Cubosomes-assisted transdermal delivery of doxorubicin and indocyanine green for chemo-photothermal combination therapy of melanoma |
| title_fullStr | Cubosomes-assisted transdermal delivery of doxorubicin and indocyanine green for chemo-photothermal combination therapy of melanoma |
| title_full_unstemmed | Cubosomes-assisted transdermal delivery of doxorubicin and indocyanine green for chemo-photothermal combination therapy of melanoma |
| title_short | Cubosomes-assisted transdermal delivery of doxorubicin and indocyanine green for chemo-photothermal combination therapy of melanoma |
| title_sort | cubosomes assisted transdermal delivery of doxorubicin and indocyanine green for chemo photothermal combination therapy of melanoma |
| topic | Cubosomes Doxorubicin Indocyanine green Chemo-photothermal combination therapy Transdermal delivery Melanoma |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223011071 |
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