Low abundance of Akkermansia muciniphila and low consumption of polyphenols associated with metabolic disorders in child population
A polyphenol-rich diet modulates the abundance of Akkermansia muciniphila (A. muciniphila), protecting against metabolic disorders caused by several pathologies such as obesity. The aim of this study was to determine if the polyphenol intake and the A. muciniphila abundance are related to metabolic...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
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| Series: | Human Nutrition & Metabolism |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666149722000305 |
| _version_ | 1811187932090859520 |
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| author | Margarita Bahena-Román Ilse A. Gutiérrez-Pérez Yaneth Citlalli Orbe-Orihuela Cinthya E. Díaz-Benítez Alfredo Lagunas-Martínez Juan Carlos Ayala-García Ana Cristina Castañeda-Márquez Víctor Hugo Bermúdez-Morales Jesús Peralta-Romero Miguel Cruz Ana I. Burguete-García |
| author_facet | Margarita Bahena-Román Ilse A. Gutiérrez-Pérez Yaneth Citlalli Orbe-Orihuela Cinthya E. Díaz-Benítez Alfredo Lagunas-Martínez Juan Carlos Ayala-García Ana Cristina Castañeda-Márquez Víctor Hugo Bermúdez-Morales Jesús Peralta-Romero Miguel Cruz Ana I. Burguete-García |
| author_sort | Margarita Bahena-Román |
| collection | DOAJ |
| description | A polyphenol-rich diet modulates the abundance of Akkermansia muciniphila (A. muciniphila), protecting against metabolic disorders caused by several pathologies such as obesity. The aim of this study was to determine if the polyphenol intake and the A. muciniphila abundance are related to metabolic disorders in Mexican children aged from 6 to 12 years old. To determine if the polyphenol intake and the relative abundance (RA) of A. muciniphila to relate to the presence of metabolic disorders in the child population, we performed a Cross-sectional study of 1190 children between 6 and 12 years of age, all of them with complete information of anthropometry, biochemical parameters and RA of A. muciniphila. The polyphenol intake was assessed through a food consumption frequency questionnaire. The findings showed a positive association between low RA of A. muciniphila with triglycerides 6.89 mg/dL (95%CI 0.5, 14.2) and negative with high-density lipoproteins (HDL) −1.35 mg/dL (95%CI -3.4, −0.6). The low intake of anthocyanins and flavan-3-ols are positively associated with triglycerides, 7.35 mg/dL (95%CI 1.80, 12.89) and 5.66 mg/dL (95%CI 0.013, 11.32), respectively. Conclusion: The low RA of A. muciniphila and less intake of polyphenols are directly associated to lipid disorders in child. |
| first_indexed | 2024-04-11T14:10:51Z |
| format | Article |
| id | doaj.art-f09939f445504359972e11251e999b53 |
| institution | Directory Open Access Journal |
| issn | 2666-1497 |
| language | English |
| last_indexed | 2024-04-11T14:10:51Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Nutrition & Metabolism |
| spelling | doaj.art-f09939f445504359972e11251e999b532022-12-22T04:19:42ZengElsevierHuman Nutrition & Metabolism2666-14972022-12-0130200167Low abundance of Akkermansia muciniphila and low consumption of polyphenols associated with metabolic disorders in child populationMargarita Bahena-Román0Ilse A. Gutiérrez-Pérez1Yaneth Citlalli Orbe-Orihuela2Cinthya E. Díaz-Benítez3Alfredo Lagunas-Martínez4Juan Carlos Ayala-García5Ana Cristina Castañeda-Márquez6Víctor Hugo Bermúdez-Morales7Jesús Peralta-Romero8Miguel Cruz9Ana I. Burguete-García10Centro de Investigación sobre Enfermedades Infecciosas, INSP, Cuernavaca, Morelos, 62100, MexicoCentro de Investigación sobre Enfermedades Infecciosas, INSP, Cuernavaca, Morelos, 62100, MexicoCentro de Investigación sobre Enfermedades Infecciosas, INSP, Cuernavaca, Morelos, 62100, MexicoCentro de Investigación sobre Enfermedades Infecciosas, INSP, Cuernavaca, Morelos, 62100, MexicoCentro de Investigación sobre Enfermedades Infecciosas, INSP, Cuernavaca, Morelos, 62100, MexicoCentro de Investigación sobre Enfermedades Infecciosas, INSP, Cuernavaca, Morelos, 62100, MexicoCentro de Investigación sobre Enfermedades Infecciosas, INSP, Cuernavaca, Morelos, 62100, MexicoCentro de Investigación sobre Enfermedades Infecciosas, INSP, Cuernavaca, Morelos, 62100, MexicoUnidad de Investigación Médica en Bioquímica, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Juárez, Ciudad de México, CDMX, 06600, MexicoUnidad de Investigación Médica en Bioquímica, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Juárez, Ciudad de México, CDMX, 06600, MexicoCentro de Investigación sobre Enfermedades Infecciosas, INSP, Cuernavaca, Morelos, 62100, Mexico; Corresponding author. Centro de Investigación sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Mexico.A polyphenol-rich diet modulates the abundance of Akkermansia muciniphila (A. muciniphila), protecting against metabolic disorders caused by several pathologies such as obesity. The aim of this study was to determine if the polyphenol intake and the A. muciniphila abundance are related to metabolic disorders in Mexican children aged from 6 to 12 years old. To determine if the polyphenol intake and the relative abundance (RA) of A. muciniphila to relate to the presence of metabolic disorders in the child population, we performed a Cross-sectional study of 1190 children between 6 and 12 years of age, all of them with complete information of anthropometry, biochemical parameters and RA of A. muciniphila. The polyphenol intake was assessed through a food consumption frequency questionnaire. The findings showed a positive association between low RA of A. muciniphila with triglycerides 6.89 mg/dL (95%CI 0.5, 14.2) and negative with high-density lipoproteins (HDL) −1.35 mg/dL (95%CI -3.4, −0.6). The low intake of anthocyanins and flavan-3-ols are positively associated with triglycerides, 7.35 mg/dL (95%CI 1.80, 12.89) and 5.66 mg/dL (95%CI 0.013, 11.32), respectively. Conclusion: The low RA of A. muciniphila and less intake of polyphenols are directly associated to lipid disorders in child.http://www.sciencedirect.com/science/article/pii/S2666149722000305Akkermansia muciniphilaPolyphenolsMetabolic disordersChild population |
| spellingShingle | Margarita Bahena-Román Ilse A. Gutiérrez-Pérez Yaneth Citlalli Orbe-Orihuela Cinthya E. Díaz-Benítez Alfredo Lagunas-Martínez Juan Carlos Ayala-García Ana Cristina Castañeda-Márquez Víctor Hugo Bermúdez-Morales Jesús Peralta-Romero Miguel Cruz Ana I. Burguete-García Low abundance of Akkermansia muciniphila and low consumption of polyphenols associated with metabolic disorders in child population Human Nutrition & Metabolism Akkermansia muciniphila Polyphenols Metabolic disorders Child population |
| title | Low abundance of Akkermansia muciniphila and low consumption of polyphenols associated with metabolic disorders in child population |
| title_full | Low abundance of Akkermansia muciniphila and low consumption of polyphenols associated with metabolic disorders in child population |
| title_fullStr | Low abundance of Akkermansia muciniphila and low consumption of polyphenols associated with metabolic disorders in child population |
| title_full_unstemmed | Low abundance of Akkermansia muciniphila and low consumption of polyphenols associated with metabolic disorders in child population |
| title_short | Low abundance of Akkermansia muciniphila and low consumption of polyphenols associated with metabolic disorders in child population |
| title_sort | low abundance of akkermansia muciniphila and low consumption of polyphenols associated with metabolic disorders in child population |
| topic | Akkermansia muciniphila Polyphenols Metabolic disorders Child population |
| url | http://www.sciencedirect.com/science/article/pii/S2666149722000305 |
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