Hormonal Receptors, Human Epidermal Growth Factor Receptor-2 and Triple Negative Immunohistochemical Typing in Women with Breast Cancer in Kampala, Uganda
Angela T Mlole, 1 James J Yahaya, 2 Emmanuel Othieno, 3 Sam Kalungi, 3 Andrew L Okwi 1 1Department of Pathology, Makerere College of Health Sciences (MaKCHS), Makerere University, Kampala, Uganda; 2Department of Biomedical Science, College of Health Science (CHS), The University of Dodoma, Dodoma,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-11-01
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| Series: | International Journal of Women's Health |
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| Online Access: | https://www.dovepress.com/hormonal-receptors-human-epidermal-growth-factor-receptor-2-and-triple-peer-reviewed-article-IJWH |
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| author | Mlole AT Yahaya JJ Othieno E Kalungi S Okwi AL |
| author_facet | Mlole AT Yahaya JJ Othieno E Kalungi S Okwi AL |
| author_sort | Mlole AT |
| collection | DOAJ |
| description | Angela T Mlole, 1 James J Yahaya, 2 Emmanuel Othieno, 3 Sam Kalungi, 3 Andrew L Okwi 1 1Department of Pathology, Makerere College of Health Sciences (MaKCHS), Makerere University, Kampala, Uganda; 2Department of Biomedical Science, College of Health Science (CHS), The University of Dodoma, Dodoma, Tanzania; 3Department of Pathology, Mulago National Hospital, Kampala, UgandaCorrespondence: James J Yahaya Department of Biomedical ScienceCollege of Health Science (CHS), The University of Dodoma, P.O. Box 395, Dodoma, TanzaniaEmail mashimba2009@yahoo.comBackground: The expression of estrogen and progesterone receptors (ER and PR) and human epidermal growth factor receptor-2 (HER2) has been reported to have an invaluable prognostic role. The aim of this study was to determine the expression of ER, PR and HER2 in women with breast cancer (BC) in Kampala, Uganda.Methods: Expression of ER, PR and HER2 was determined immunohistochemically. Logistic regression was performed to determine the effect of the independent factors in predicting the risk of not expressing the breast markers. A two-tailed p< 0.05 was regarded to be statistically significant.Results: ER, PR and HER2 were expressed in 53.4%, 46.6% and 18.5%, respectively. ER and PR co-expression was present in 42.7% and 37.9% patients had triple negative breast cancer (TNBC). Age was an independent predictor of expression of ER (AOR = 0.18, 95% CI = 0.062– 0.541, p = 0.002) and PR (AOR = 0.35, 95% CI = 0.129– 0.968, p = 0.043).Conclusion: The majority of patients in this study had less than 50 years with high tumour grade. Interestingly, most of them had high expression of HER2 with TNBC which are molecular subtypes of BC with poor prognosis. Age was an independent predictor of expression of both ER and PR.Keywords: hormonal receptors, HER2, triple negative, breast cancer, Uganda |
| first_indexed | 2024-12-17T01:05:53Z |
| format | Article |
| id | doaj.art-f099a5fee5f047a8b64074e9e262a963 |
| institution | Directory Open Access Journal |
| issn | 1179-1411 |
| language | English |
| last_indexed | 2024-12-17T01:05:53Z |
| publishDate | 2020-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Women's Health |
| spelling | doaj.art-f099a5fee5f047a8b64074e9e262a9632022-12-21T22:09:17ZengDove Medical PressInternational Journal of Women's Health1179-14112020-11-01Volume 121109112359752Hormonal Receptors, Human Epidermal Growth Factor Receptor-2 and Triple Negative Immunohistochemical Typing in Women with Breast Cancer in Kampala, UgandaMlole ATYahaya JJOthieno EKalungi SOkwi ALAngela T Mlole, 1 James J Yahaya, 2 Emmanuel Othieno, 3 Sam Kalungi, 3 Andrew L Okwi 1 1Department of Pathology, Makerere College of Health Sciences (MaKCHS), Makerere University, Kampala, Uganda; 2Department of Biomedical Science, College of Health Science (CHS), The University of Dodoma, Dodoma, Tanzania; 3Department of Pathology, Mulago National Hospital, Kampala, UgandaCorrespondence: James J Yahaya Department of Biomedical ScienceCollege of Health Science (CHS), The University of Dodoma, P.O. Box 395, Dodoma, TanzaniaEmail mashimba2009@yahoo.comBackground: The expression of estrogen and progesterone receptors (ER and PR) and human epidermal growth factor receptor-2 (HER2) has been reported to have an invaluable prognostic role. The aim of this study was to determine the expression of ER, PR and HER2 in women with breast cancer (BC) in Kampala, Uganda.Methods: Expression of ER, PR and HER2 was determined immunohistochemically. Logistic regression was performed to determine the effect of the independent factors in predicting the risk of not expressing the breast markers. A two-tailed p< 0.05 was regarded to be statistically significant.Results: ER, PR and HER2 were expressed in 53.4%, 46.6% and 18.5%, respectively. ER and PR co-expression was present in 42.7% and 37.9% patients had triple negative breast cancer (TNBC). Age was an independent predictor of expression of ER (AOR = 0.18, 95% CI = 0.062– 0.541, p = 0.002) and PR (AOR = 0.35, 95% CI = 0.129– 0.968, p = 0.043).Conclusion: The majority of patients in this study had less than 50 years with high tumour grade. Interestingly, most of them had high expression of HER2 with TNBC which are molecular subtypes of BC with poor prognosis. Age was an independent predictor of expression of both ER and PR.Keywords: hormonal receptors, HER2, triple negative, breast cancer, Ugandahttps://www.dovepress.com/hormonal-receptors-human-epidermal-growth-factor-receptor-2-and-triple-peer-reviewed-article-IJWHhormonal receptorsher2triple negativebreast canceruganda. |
| spellingShingle | Mlole AT Yahaya JJ Othieno E Kalungi S Okwi AL Hormonal Receptors, Human Epidermal Growth Factor Receptor-2 and Triple Negative Immunohistochemical Typing in Women with Breast Cancer in Kampala, Uganda International Journal of Women's Health hormonal receptors her2 triple negative breast cancer uganda. |
| title | Hormonal Receptors, Human Epidermal Growth Factor Receptor-2 and Triple Negative Immunohistochemical Typing in Women with Breast Cancer in Kampala, Uganda |
| title_full | Hormonal Receptors, Human Epidermal Growth Factor Receptor-2 and Triple Negative Immunohistochemical Typing in Women with Breast Cancer in Kampala, Uganda |
| title_fullStr | Hormonal Receptors, Human Epidermal Growth Factor Receptor-2 and Triple Negative Immunohistochemical Typing in Women with Breast Cancer in Kampala, Uganda |
| title_full_unstemmed | Hormonal Receptors, Human Epidermal Growth Factor Receptor-2 and Triple Negative Immunohistochemical Typing in Women with Breast Cancer in Kampala, Uganda |
| title_short | Hormonal Receptors, Human Epidermal Growth Factor Receptor-2 and Triple Negative Immunohistochemical Typing in Women with Breast Cancer in Kampala, Uganda |
| title_sort | hormonal receptors human epidermal growth factor receptor 2 and triple negative immunohistochemical typing in women with breast cancer in kampala uganda |
| topic | hormonal receptors her2 triple negative breast cancer uganda. |
| url | https://www.dovepress.com/hormonal-receptors-human-epidermal-growth-factor-receptor-2-and-triple-peer-reviewed-article-IJWH |
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