Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region
We report two ciprofloxacin and ofloxacin-resistant Neisseria gonorrhoeae strains that were isolated from the urethral discharge of male patients at the sexually transmitted diseases outpatient clinic of the Alfredo da Matta Foundation (Manaus, state of Amazonas, Brazil). The gonococci displayed min...
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Format: | Article |
Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2011-08-01
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Series: | Memorias do Instituto Oswaldo Cruz |
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000500018&lng=en&tlng=en |
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author | William Antunes Ferreira Cristina Motta Ferreira Felipe Gomes Naveca Nayanne Cristina Oliveira da Silva Almeida Waldemara de Souza Vasconcelos Jairo de Souza Gomes Maria de Fátima Pinto da Silva Maria das Graças Costa Alecrim |
author_facet | William Antunes Ferreira Cristina Motta Ferreira Felipe Gomes Naveca Nayanne Cristina Oliveira da Silva Almeida Waldemara de Souza Vasconcelos Jairo de Souza Gomes Maria de Fátima Pinto da Silva Maria das Graças Costa Alecrim |
author_sort | William Antunes Ferreira |
collection | DOAJ |
description | We report two ciprofloxacin and ofloxacin-resistant Neisseria gonorrhoeae strains that were isolated from the urethral discharge of male patients at the sexually transmitted diseases outpatient clinic of the Alfredo da Matta Foundation (Manaus, state of Amazonas, Brazil). The gonococci displayed minimal inhibitory concentrations (> 32.00 µg/mL) and three mutations in the quinolone resistance-determining region (S91F and D95G in GyrA and S87R in ParC). Both isolates were genotyped using N. gonorrhoeae multi-antigen sequence typing and the analysis showed that the ST225 which represented an emerging widespread multi-resistant clone that has also been associated with reduced susceptibility to ceftriaxone. We recommend continued surveillance of this pathogen to assess the efficacy of anti-gonococcal antibiotics in Brazil. |
first_indexed | 2024-03-12T07:34:38Z |
format | Article |
id | doaj.art-f09a086fc9e04f459ae0e5baf6547260 |
institution | Directory Open Access Journal |
issn | 1678-8060 |
language | English |
last_indexed | 2024-03-12T07:34:38Z |
publishDate | 2011-08-01 |
publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
record_format | Article |
series | Memorias do Instituto Oswaldo Cruz |
spelling | doaj.art-f09a086fc9e04f459ae0e5baf65472602023-09-02T21:33:28ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602011-08-01106562963110.1590/S0074-02762011000500018S0074-02762011000500018Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon RegionWilliam Antunes Ferreira0Cristina Motta Ferreira1Felipe Gomes Naveca2Nayanne Cristina Oliveira da Silva Almeida3Waldemara de Souza Vasconcelos4Jairo de Souza Gomes5Maria de Fátima Pinto da Silva6Maria das Graças Costa Alecrim7Universidade Estadual do AmazonasFundação de Hematologia e Hemoterapia do AmazonasFundação Oswaldo CruzUniversidade Federal do AmazonasUniversidade Estadual do AmazonasUniversidade Estadual do AmazonasUniversidade Estadual do AmazonasFundação de Medicina Tropical Dr. Heitor Vieira DouradoWe report two ciprofloxacin and ofloxacin-resistant Neisseria gonorrhoeae strains that were isolated from the urethral discharge of male patients at the sexually transmitted diseases outpatient clinic of the Alfredo da Matta Foundation (Manaus, state of Amazonas, Brazil). The gonococci displayed minimal inhibitory concentrations (> 32.00 µg/mL) and three mutations in the quinolone resistance-determining region (S91F and D95G in GyrA and S87R in ParC). Both isolates were genotyped using N. gonorrhoeae multi-antigen sequence typing and the analysis showed that the ST225 which represented an emerging widespread multi-resistant clone that has also been associated with reduced susceptibility to ceftriaxone. We recommend continued surveillance of this pathogen to assess the efficacy of anti-gonococcal antibiotics in Brazil.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000500018&lng=en&tlng=enNeisseria gonorrhoeaefluroquinolone resistancegyrA and parCgenotypingMAST |
spellingShingle | William Antunes Ferreira Cristina Motta Ferreira Felipe Gomes Naveca Nayanne Cristina Oliveira da Silva Almeida Waldemara de Souza Vasconcelos Jairo de Souza Gomes Maria de Fátima Pinto da Silva Maria das Graças Costa Alecrim Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region Memorias do Instituto Oswaldo Cruz Neisseria gonorrhoeae fluroquinolone resistance gyrA and parC genotyping MAST |
title | Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region |
title_full | Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region |
title_fullStr | Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region |
title_full_unstemmed | Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region |
title_short | Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region |
title_sort | genotyping of two neisseria gonorrhoeae fluroquinolone resistant strains in the brazilian amazon region |
topic | Neisseria gonorrhoeae fluroquinolone resistance gyrA and parC genotyping MAST |
url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000500018&lng=en&tlng=en |
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