The epidemiology of varicella and effectiveness of varicella vaccine in Ganyu, China: a long-term community surveillance study
Abstract Background The real-world data of long-term protection under moderate vaccination coverage is limited. This study aimed to evaluate varicella epidemiology and the long-term effectiveness under moderate coverage levels in Ganyu District, Lianyungang City, Jiangsu Province. Methods This was a...
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| Format: | Article |
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BMC
2023-09-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-023-16304-4 |
| _version_ | 1797451236409081856 |
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| author | Lingxian Qiu Sheng Liu Minglei Zhang Guohua Zhong Siying Peng Jiali Quan Hongyan Lin Xiaowen Hu Kongxin Zhu Xingcheng Huang Junchao Peng Yue Huang Shoujie Huang Ting Wu Jinbo Xu Zifang Dong Qi Liang Wei Wang Yingying Su Jun Zhang Ningshao Xia |
| author_facet | Lingxian Qiu Sheng Liu Minglei Zhang Guohua Zhong Siying Peng Jiali Quan Hongyan Lin Xiaowen Hu Kongxin Zhu Xingcheng Huang Junchao Peng Yue Huang Shoujie Huang Ting Wu Jinbo Xu Zifang Dong Qi Liang Wei Wang Yingying Su Jun Zhang Ningshao Xia |
| author_sort | Lingxian Qiu |
| collection | DOAJ |
| description | Abstract Background The real-world data of long-term protection under moderate vaccination coverage is limited. This study aimed to evaluate varicella epidemiology and the long-term effectiveness under moderate coverage levels in Ganyu District, Lianyungang City, Jiangsu Province. Methods This was a population-based, retrospective birth cohort study based on the immunization information system (IIS) and the National Notifiable Disease Surveillance System (NNDSS) in Ganyu District. Varicella cases reported from 2009 to 2020 were included to describe the epidemiology of varicella, and eleven-year consecutive birth cohorts (2008–2018) were included to estimate the vaccine effectiveness (VE) of varicella by Cox regression analysis. Results A total of 155,232 native children and 3,251 varicella cases were included. The vaccination coverage was moderate with 37.1%, correspondingly, the annual incidence of varicella infection increased 4.4-fold from 2009 to 2020. A shift of the varicella cases to older age groups was observed, with the peak proportion of cases shifting from 5–6 year-old to 7–8 year-old. The adjusted effectiveness of one dose of vaccine waned over time, and the adjusted VE decreased from 72.9% to 41.8% in the one-dose group. Conclusions The insufficient vaccination coverage (37.1%) may have contributed in part to the rising annual incidence of varicella infection, and a shift of varicella cases to older age groups occurred. The effectiveness of one dose of varicella vaccine was moderate and waned over time. It is urgent to increase varicella vaccine coverage to 80% to reduce the incidence of varicella and prevent any potential shift in the age at infection in China. |
| first_indexed | 2024-03-09T14:51:48Z |
| format | Article |
| id | doaj.art-f09b23248773450aa764771a7cb7466f |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-03-09T14:51:48Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-f09b23248773450aa764771a7cb7466f2023-11-26T14:28:19ZengBMCBMC Public Health1471-24582023-09-0123111010.1186/s12889-023-16304-4The epidemiology of varicella and effectiveness of varicella vaccine in Ganyu, China: a long-term community surveillance studyLingxian Qiu0Sheng Liu1Minglei Zhang2Guohua Zhong3Siying Peng4Jiali Quan5Hongyan Lin6Xiaowen Hu7Kongxin Zhu8Xingcheng Huang9Junchao Peng10Yue Huang11Shoujie Huang12Ting Wu13Jinbo Xu14Zifang Dong15Qi Liang16Wei Wang17Yingying Su18Jun Zhang19Ningshao Xia20State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen UniversityGanyu County Center for Disease Control and Prevention, Ganyu CountyGanyu County Center for Disease Control and Prevention, Ganyu CountyState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen UniversityState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen UniversityState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen UniversityState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen UniversityState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen UniversityState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen UniversityState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen UniversityInformation Technology and Laboratory Management Center, Wuyi UniversityState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen UniversityState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen UniversityState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen UniversityGanyu County Center for Disease Control and Prevention, Ganyu CountyGanyu County Center for Disease Control and Prevention, Ganyu CountyJiangsu Provincial Center for Disease Control and PreventionState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen UniversityState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen UniversityState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen UniversityState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, Xiamen UniversityAbstract Background The real-world data of long-term protection under moderate vaccination coverage is limited. This study aimed to evaluate varicella epidemiology and the long-term effectiveness under moderate coverage levels in Ganyu District, Lianyungang City, Jiangsu Province. Methods This was a population-based, retrospective birth cohort study based on the immunization information system (IIS) and the National Notifiable Disease Surveillance System (NNDSS) in Ganyu District. Varicella cases reported from 2009 to 2020 were included to describe the epidemiology of varicella, and eleven-year consecutive birth cohorts (2008–2018) were included to estimate the vaccine effectiveness (VE) of varicella by Cox regression analysis. Results A total of 155,232 native children and 3,251 varicella cases were included. The vaccination coverage was moderate with 37.1%, correspondingly, the annual incidence of varicella infection increased 4.4-fold from 2009 to 2020. A shift of the varicella cases to older age groups was observed, with the peak proportion of cases shifting from 5–6 year-old to 7–8 year-old. The adjusted effectiveness of one dose of vaccine waned over time, and the adjusted VE decreased from 72.9% to 41.8% in the one-dose group. Conclusions The insufficient vaccination coverage (37.1%) may have contributed in part to the rising annual incidence of varicella infection, and a shift of varicella cases to older age groups occurred. The effectiveness of one dose of varicella vaccine was moderate and waned over time. It is urgent to increase varicella vaccine coverage to 80% to reduce the incidence of varicella and prevent any potential shift in the age at infection in China.https://doi.org/10.1186/s12889-023-16304-4Community surveillanceEpidemiologyLong-termVaricellaVaccine effectiveness |
| spellingShingle | Lingxian Qiu Sheng Liu Minglei Zhang Guohua Zhong Siying Peng Jiali Quan Hongyan Lin Xiaowen Hu Kongxin Zhu Xingcheng Huang Junchao Peng Yue Huang Shoujie Huang Ting Wu Jinbo Xu Zifang Dong Qi Liang Wei Wang Yingying Su Jun Zhang Ningshao Xia The epidemiology of varicella and effectiveness of varicella vaccine in Ganyu, China: a long-term community surveillance study BMC Public Health Community surveillance Epidemiology Long-term Varicella Vaccine effectiveness |
| title | The epidemiology of varicella and effectiveness of varicella vaccine in Ganyu, China: a long-term community surveillance study |
| title_full | The epidemiology of varicella and effectiveness of varicella vaccine in Ganyu, China: a long-term community surveillance study |
| title_fullStr | The epidemiology of varicella and effectiveness of varicella vaccine in Ganyu, China: a long-term community surveillance study |
| title_full_unstemmed | The epidemiology of varicella and effectiveness of varicella vaccine in Ganyu, China: a long-term community surveillance study |
| title_short | The epidemiology of varicella and effectiveness of varicella vaccine in Ganyu, China: a long-term community surveillance study |
| title_sort | epidemiology of varicella and effectiveness of varicella vaccine in ganyu china a long term community surveillance study |
| topic | Community surveillance Epidemiology Long-term Varicella Vaccine effectiveness |
| url | https://doi.org/10.1186/s12889-023-16304-4 |
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