Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice

Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice

Dysregulation of excitatory amino acid transporter 2 (EAAT2) contributes to the development of temporal lobe epilepsy (TLE). Several strategies for increasing total EAAT2 levels have been proposed. However, the mechanism underlying the oligomeric assembly of EAAT2, impairment of which inhibits the f...

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Bibliographic Details
Main Authors: Longze Sha, Guanjun Li, Xiuneng Zhang, Yarong Lin, Yunjie Qiu, Yu Deng, Wanwan Zhu, Qi Xu
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-08-01
Series:JCI Insight
Subjects:
Neuroscience
Online Access:https://doi.org/10.1172/jci.insight.160247

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