Evaluation of Antibacterial and Cytotoxicity Properties of Silver Nanowires and Their Composites with Carbon Nanotubes for Biomedical Applications
In this work, we prepared silver nanowires (AgNWs) via the polyol method in the presence or absence of single wall carbon nanotubes (CNTs) and tested their physicochemical, antibacterial and cytotoxic properties. Results showed that the introduction of CNTs lead to the formation of AgNWs at lower te...
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| Format: | Article |
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MDPI AG
2020-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/7/2303 |
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| author | Arianna De Mori Richard S. Jones Matteo Cretella Guido Cerri Roger R. Draheim Eugen Barbu Gianluca Tozzi Marta Roldo |
| author_facet | Arianna De Mori Richard S. Jones Matteo Cretella Guido Cerri Roger R. Draheim Eugen Barbu Gianluca Tozzi Marta Roldo |
| author_sort | Arianna De Mori |
| collection | DOAJ |
| description | In this work, we prepared silver nanowires (AgNWs) via the polyol method in the presence or absence of single wall carbon nanotubes (CNTs) and tested their physicochemical, antibacterial and cytotoxic properties. Results showed that the introduction of CNTs lead to the formation of AgNWs at lower temperature, but the final product characteristics of AgNWs and AgNWs-CNT were not significantly different. AgNWs exhibited antibacterial properties against all the studied bacterial species via the formation of oxygen reactive species (ROS) and membrane damage. Furthermore, AgNWs exhibited a dose-dependent and time-dependent toxicity at concentrations ≥ 10 µg/mL. Fibroblasts appeared to be more resistant than human colorectal adenocarcinoma (Caco-2) and osteoblasts to the toxicity of AgNWs. The cytotoxicity of AgNWs was found to be related to the formation of ROS, but not to membrane damage. Overall, these results suggest that AgNWs are potential antibacterial agents against <i>E. coli</i>, <i>S. aureus</i>, MRSA and <i>S. saprophyticus</i>, but their dosage needs to be adjusted according to the route of administration. |
| first_indexed | 2024-04-12T03:51:19Z |
| format | Article |
| id | doaj.art-f09b51b9909d46eb9ae9a883874ddfec |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T03:51:19Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f09b51b9909d46eb9ae9a883874ddfec2022-12-22T03:48:58ZengMDPI AGInternational Journal of Molecular Sciences1422-00672020-03-01217230310.3390/ijms21072303ijms21072303Evaluation of Antibacterial and Cytotoxicity Properties of Silver Nanowires and Their Composites with Carbon Nanotubes for Biomedical ApplicationsArianna De Mori0Richard S. Jones1Matteo Cretella2Guido Cerri3Roger R. Draheim4Eugen Barbu5Gianluca Tozzi6Marta Roldo7School of Pharmacy and Biomedical Science, University of Portsmouth, St Michael’s Building, White Swan Road, PO1 2DT, Portsmouth, UKSchool of Pharmacy and Biomedical Science, University of Portsmouth, St Michael’s Building, White Swan Road, PO1 2DT, Portsmouth, UKSchool of Pharmacy and Biomedical Science, University of Portsmouth, St Michael’s Building, White Swan Road, PO1 2DT, Portsmouth, UKDepartment of Architecture, Design and Urban Planning—GeoMaterials Lab, University of Sassari, Via Piandanna 4, 07100 Sassari, ItalySchool of Pharmacy and Biomedical Science, University of Portsmouth, St Michael’s Building, White Swan Road, PO1 2DT, Portsmouth, UKSchool of Pharmacy and Biomedical Science, University of Portsmouth, St Michael’s Building, White Swan Road, PO1 2DT, Portsmouth, UKZeiss Global Centre, School of Engineering, University of Portsmouth, Anglesea Building, Anglesea Road, PO1 3DJ Portsmouth, UKSchool of Pharmacy and Biomedical Science, University of Portsmouth, St Michael’s Building, White Swan Road, PO1 2DT, Portsmouth, UKIn this work, we prepared silver nanowires (AgNWs) via the polyol method in the presence or absence of single wall carbon nanotubes (CNTs) and tested their physicochemical, antibacterial and cytotoxic properties. Results showed that the introduction of CNTs lead to the formation of AgNWs at lower temperature, but the final product characteristics of AgNWs and AgNWs-CNT were not significantly different. AgNWs exhibited antibacterial properties against all the studied bacterial species via the formation of oxygen reactive species (ROS) and membrane damage. Furthermore, AgNWs exhibited a dose-dependent and time-dependent toxicity at concentrations ≥ 10 µg/mL. Fibroblasts appeared to be more resistant than human colorectal adenocarcinoma (Caco-2) and osteoblasts to the toxicity of AgNWs. The cytotoxicity of AgNWs was found to be related to the formation of ROS, but not to membrane damage. Overall, these results suggest that AgNWs are potential antibacterial agents against <i>E. coli</i>, <i>S. aureus</i>, MRSA and <i>S. saprophyticus</i>, but their dosage needs to be adjusted according to the route of administration.https://www.mdpi.com/1422-0067/21/7/2303silver nanowiresnanomaterialsbiocompatibility |
| spellingShingle | Arianna De Mori Richard S. Jones Matteo Cretella Guido Cerri Roger R. Draheim Eugen Barbu Gianluca Tozzi Marta Roldo Evaluation of Antibacterial and Cytotoxicity Properties of Silver Nanowires and Their Composites with Carbon Nanotubes for Biomedical Applications International Journal of Molecular Sciences silver nanowires nanomaterials biocompatibility |
| title | Evaluation of Antibacterial and Cytotoxicity Properties of Silver Nanowires and Their Composites with Carbon Nanotubes for Biomedical Applications |
| title_full | Evaluation of Antibacterial and Cytotoxicity Properties of Silver Nanowires and Their Composites with Carbon Nanotubes for Biomedical Applications |
| title_fullStr | Evaluation of Antibacterial and Cytotoxicity Properties of Silver Nanowires and Their Composites with Carbon Nanotubes for Biomedical Applications |
| title_full_unstemmed | Evaluation of Antibacterial and Cytotoxicity Properties of Silver Nanowires and Their Composites with Carbon Nanotubes for Biomedical Applications |
| title_short | Evaluation of Antibacterial and Cytotoxicity Properties of Silver Nanowires and Their Composites with Carbon Nanotubes for Biomedical Applications |
| title_sort | evaluation of antibacterial and cytotoxicity properties of silver nanowires and their composites with carbon nanotubes for biomedical applications |
| topic | silver nanowires nanomaterials biocompatibility |
| url | https://www.mdpi.com/1422-0067/21/7/2303 |
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