miR‐205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling

miR‐205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling

Abstract The onset of secondary resistance represents a major limitation to long‐term efficacy of target therapies in cancer patients. Thus, the identification of mechanisms mediating secondary resistance is the key to the rational design of therapeutic strategies for resistant patients. MiRNA profi...

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Bibliographic Details
Main Authors: Cristina Migliore, Elena Morando, Elena Ghiso, Sergio Anastasi, Vera P Leoni, Maria Apicella, Davide Cora', Anna Sapino, Filippo Pietrantonio, Filippo De Braud, Amedeo Columbano, Oreste Segatto, Silvia Giordano
Format: Article
Language:English
Published: Springer Nature 2018-07-01
Series:EMBO Molecular Medicine
Subjects:
EGFR
ERRFI1
MET
resistance
targeted therapy
Online Access:https://doi.org/10.15252/emmm.201708746

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