Identification Bioactive Compound of Ethanol-Water Fraction of Coleus atropurpureus for Anti-rheumatic Rheumatism in CFA-induced Rats
Nonsteroidal anti-inflammatory drugs are used for pain and to slow the progression of rheumatoid arthritis. Accordingly, the discovery of rheumatoid arthritis active compounds from the ethanol-water fraction Coleus atropurpureus (EWC) was conducted to characterize the isolated compounds as well as t...
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| Format: | Article |
| Language: | English |
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Universitas Sanata Dharma
2022-11-01
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| Series: | Jurnal Farmasi Sains dan Komunitas |
| Subjects: | |
| Online Access: | https://e-journal.usd.ac.id/index.php/JFSK/article/view/4746 |
| _version_ | 1797785764420911104 |
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| author | Ipang Djunarko Nanang Fakhrudin Arief Nurrochmad Subagus Wahyuono |
| author_facet | Ipang Djunarko Nanang Fakhrudin Arief Nurrochmad Subagus Wahyuono |
| author_sort | Ipang Djunarko |
| collection | DOAJ |
| description | Nonsteroidal anti-inflammatory drugs are used for pain and to slow the progression of rheumatoid arthritis. Accordingly, the discovery of rheumatoid arthritis active compounds from the ethanol-water fraction Coleus atropurpureus (EWC) was conducted to characterize the isolated compounds as well as the anti-rheumatic effects of the EWC induced Complete Freund's Adjuvant (CFA). We conducted in vivo study in rats which were randomly divided into 5 groups. Group 1 was only given CFA as a negative control. Group 2 as positive control was orally exposed to diclofenac potassium (9 mg/BW). Three groups were given different EWCs orally as follows: 11.25 mg/BW, 22.5 mg/BW, and 45 mg/BW, respectively. Rheumatism rates were then compared with positive controls using a visual arthritic scoring system. The compounds identified by isolation of the EWC of Coleus atropurpureus predicted forskolin. The ethanol-water fraction Coleus atropurpureus did not act as an anti-rheumatic arthritis agent in CFA-induced rats. |
| first_indexed | 2024-03-13T00:59:35Z |
| format | Article |
| id | doaj.art-f09e442ad9934e1880f281ac266ffa13 |
| institution | Directory Open Access Journal |
| issn | 1693-5683 2527-7146 |
| language | English |
| last_indexed | 2024-03-13T00:59:35Z |
| publishDate | 2022-11-01 |
| publisher | Universitas Sanata Dharma |
| record_format | Article |
| series | Jurnal Farmasi Sains dan Komunitas |
| spelling | doaj.art-f09e442ad9934e1880f281ac266ffa132023-07-06T14:00:50ZengUniversitas Sanata DharmaJurnal Farmasi Sains dan Komunitas1693-56832527-71462022-11-011929310210.24071/jpsc.0047462611Identification Bioactive Compound of Ethanol-Water Fraction of Coleus atropurpureus for Anti-rheumatic Rheumatism in CFA-induced RatsIpang Djunarko0Nanang Fakhrudin1Arief Nurrochmad2Subagus Wahyuono3Postgraduate Program of Pharmacy, Faculty of Pharmacy, Gadjah Mada UniversityDepartment of Pharmaceutical Biology, Faculty of Pharmacy, Gadjah Mada UniversityDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Gadjah Mada UniversityDepartment of Pharmaceutical Biology, Faculty of Pharmacy, Gadjah Mada UniversityNonsteroidal anti-inflammatory drugs are used for pain and to slow the progression of rheumatoid arthritis. Accordingly, the discovery of rheumatoid arthritis active compounds from the ethanol-water fraction Coleus atropurpureus (EWC) was conducted to characterize the isolated compounds as well as the anti-rheumatic effects of the EWC induced Complete Freund's Adjuvant (CFA). We conducted in vivo study in rats which were randomly divided into 5 groups. Group 1 was only given CFA as a negative control. Group 2 as positive control was orally exposed to diclofenac potassium (9 mg/BW). Three groups were given different EWCs orally as follows: 11.25 mg/BW, 22.5 mg/BW, and 45 mg/BW, respectively. Rheumatism rates were then compared with positive controls using a visual arthritic scoring system. The compounds identified by isolation of the EWC of Coleus atropurpureus predicted forskolin. The ethanol-water fraction Coleus atropurpureus did not act as an anti-rheumatic arthritis agent in CFA-induced rats.https://e-journal.usd.ac.id/index.php/JFSK/article/view/4746anti-rheumatic arthritiscoleus atropurpureuscomplete freund's adjuvant |
| spellingShingle | Ipang Djunarko Nanang Fakhrudin Arief Nurrochmad Subagus Wahyuono Identification Bioactive Compound of Ethanol-Water Fraction of Coleus atropurpureus for Anti-rheumatic Rheumatism in CFA-induced Rats Jurnal Farmasi Sains dan Komunitas anti-rheumatic arthritis coleus atropurpureus complete freund's adjuvant |
| title | Identification Bioactive Compound of Ethanol-Water Fraction of Coleus atropurpureus for Anti-rheumatic Rheumatism in CFA-induced Rats |
| title_full | Identification Bioactive Compound of Ethanol-Water Fraction of Coleus atropurpureus for Anti-rheumatic Rheumatism in CFA-induced Rats |
| title_fullStr | Identification Bioactive Compound of Ethanol-Water Fraction of Coleus atropurpureus for Anti-rheumatic Rheumatism in CFA-induced Rats |
| title_full_unstemmed | Identification Bioactive Compound of Ethanol-Water Fraction of Coleus atropurpureus for Anti-rheumatic Rheumatism in CFA-induced Rats |
| title_short | Identification Bioactive Compound of Ethanol-Water Fraction of Coleus atropurpureus for Anti-rheumatic Rheumatism in CFA-induced Rats |
| title_sort | identification bioactive compound of ethanol water fraction of coleus atropurpureus for anti rheumatic rheumatism in cfa induced rats |
| topic | anti-rheumatic arthritis coleus atropurpureus complete freund's adjuvant |
| url | https://e-journal.usd.ac.id/index.php/JFSK/article/view/4746 |
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