Solenoidal Micromagnetic Stimulation Enables Activation of Axons With Specific Orientation
Electrical stimulation of the central and peripheral nervous systems - such as deep brain stimulation, spinal cord stimulation, and epidural cortical stimulation are common therapeutic options increasingly used to treat a large variety of neurological and psychiatric conditions. Despite their remark...
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| Format: | Article |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.00724/full |
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| author | Laleh Golestanirad Laleh Golestanirad John T. Gale Nauman F. Manzoor Nauman F. Manzoor Hyun-Joo Park Lyall Glait Lyall Glait Frederick Haer James A. Kaltenbach Giorgio Bonmassar Giorgio Bonmassar |
| author_facet | Laleh Golestanirad Laleh Golestanirad John T. Gale Nauman F. Manzoor Nauman F. Manzoor Hyun-Joo Park Lyall Glait Lyall Glait Frederick Haer James A. Kaltenbach Giorgio Bonmassar Giorgio Bonmassar |
| author_sort | Laleh Golestanirad |
| collection | DOAJ |
| description | Electrical stimulation of the central and peripheral nervous systems - such as deep brain stimulation, spinal cord stimulation, and epidural cortical stimulation are common therapeutic options increasingly used to treat a large variety of neurological and psychiatric conditions. Despite their remarkable success, there are limitations which if overcome, could enhance outcomes and potentially reduce common side-effects. Micromagnetic stimulation (μMS) was introduced to address some of these limitations. One of the most remarkable properties is that μMS is theoretically capable of activating neurons with specific axonal orientations. Here, we used computational electromagnetic models of the μMS coils adjacent to neuronal tissue combined with axon cable models to investigate μMS orientation-specific properties. We found a 20-fold reduction in the stimulation threshold of the preferred axonal orientation compared to the orthogonal direction. We also studied the directional specificity of μMS coils by recording the responses evoked in the inferior colliculus of rodents when a pulsed magnetic stimulus was applied to the surface of the dorsal cochlear nucleus. The results confirmed that the neuronal responses were highly sensitive to changes in the μMS coil orientation. Accordingly, our results suggest that μMS has the potential of stimulating target nuclei in the brain without affecting the surrounding white matter tracts. |
| first_indexed | 2024-12-12T22:55:10Z |
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| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T22:55:10Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-f0a07341e6c44f6db10c0323a336a2cd2022-12-22T00:08:58ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-07-01910.3389/fphys.2018.00724373586Solenoidal Micromagnetic Stimulation Enables Activation of Axons With Specific OrientationLaleh Golestanirad0Laleh Golestanirad1John T. Gale2Nauman F. Manzoor3Nauman F. Manzoor4Hyun-Joo Park5Lyall Glait6Lyall Glait7Frederick Haer8James A. Kaltenbach9Giorgio Bonmassar10Giorgio Bonmassar11Athinoula A. Martinos Center, Massachusetts General Hospital, Charlestown, MA, United StatesHarvard Medical School, Boston, MA, United StatesDepartment of Neurosurgery, Emory University, Atlanta, GA, United StatesDepartment of Neurosciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United StatesEar, Nose and Throat Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, United StatesDepartment of Neurosciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United StatesDepartment of Neurosciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United StatesEar, Nose and Throat Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, United StatesFrederick Haer Corporation, Bowdoin, ME, United StatesDepartment of Neurosciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United StatesAthinoula A. Martinos Center, Massachusetts General Hospital, Charlestown, MA, United StatesHarvard Medical School, Boston, MA, United StatesElectrical stimulation of the central and peripheral nervous systems - such as deep brain stimulation, spinal cord stimulation, and epidural cortical stimulation are common therapeutic options increasingly used to treat a large variety of neurological and psychiatric conditions. Despite their remarkable success, there are limitations which if overcome, could enhance outcomes and potentially reduce common side-effects. Micromagnetic stimulation (μMS) was introduced to address some of these limitations. One of the most remarkable properties is that μMS is theoretically capable of activating neurons with specific axonal orientations. Here, we used computational electromagnetic models of the μMS coils adjacent to neuronal tissue combined with axon cable models to investigate μMS orientation-specific properties. We found a 20-fold reduction in the stimulation threshold of the preferred axonal orientation compared to the orthogonal direction. We also studied the directional specificity of μMS coils by recording the responses evoked in the inferior colliculus of rodents when a pulsed magnetic stimulus was applied to the surface of the dorsal cochlear nucleus. The results confirmed that the neuronal responses were highly sensitive to changes in the μMS coil orientation. Accordingly, our results suggest that μMS has the potential of stimulating target nuclei in the brain without affecting the surrounding white matter tracts.https://www.frontiersin.org/article/10.3389/fphys.2018.00724/fulleddy currentsTMSfinite element methodmicrocoilsinductive stimulationnumerical modeling |
| spellingShingle | Laleh Golestanirad Laleh Golestanirad John T. Gale Nauman F. Manzoor Nauman F. Manzoor Hyun-Joo Park Lyall Glait Lyall Glait Frederick Haer James A. Kaltenbach Giorgio Bonmassar Giorgio Bonmassar Solenoidal Micromagnetic Stimulation Enables Activation of Axons With Specific Orientation Frontiers in Physiology eddy currents TMS finite element method microcoils inductive stimulation numerical modeling |
| title | Solenoidal Micromagnetic Stimulation Enables Activation of Axons With Specific Orientation |
| title_full | Solenoidal Micromagnetic Stimulation Enables Activation of Axons With Specific Orientation |
| title_fullStr | Solenoidal Micromagnetic Stimulation Enables Activation of Axons With Specific Orientation |
| title_full_unstemmed | Solenoidal Micromagnetic Stimulation Enables Activation of Axons With Specific Orientation |
| title_short | Solenoidal Micromagnetic Stimulation Enables Activation of Axons With Specific Orientation |
| title_sort | solenoidal micromagnetic stimulation enables activation of axons with specific orientation |
| topic | eddy currents TMS finite element method microcoils inductive stimulation numerical modeling |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.00724/full |
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