The Effect of Moderate Hypothermia on Renin-Angiotensin – Aldosterone System in Male Rats
Hypothermia in nature occurs in hibernating animals. It has applications in medicine in open heart surgery,organ and connective tissue preserving, altitude medicine and geriatrics. Despite the vastness of studies on hypothermia many of its biologic and physiologic effects including endocrine system...
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| Format: | Article |
| Language: | fas |
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Hamadan University of Medical Sciences
2004-06-01
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| Series: | پزشکی بالینی ابن سینا |
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| Online Access: | http://sjh.umsha.ac.ir/article-1-625-en.html |
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| author | Masoumeh Kourosh Arami Saeed Khameneh Nosratollah Zarghami |
| author_facet | Masoumeh Kourosh Arami Saeed Khameneh Nosratollah Zarghami |
| author_sort | Masoumeh Kourosh Arami |
| collection | DOAJ |
| description | Hypothermia in nature occurs in hibernating animals. It has applications in medicine in open heart surgery,organ and connective tissue preserving, altitude medicine and geriatrics. Despite the vastness of studies on hypothermia many of its biologic and physiologic effects including endocrine system alterations are still poorly recognized. In this study the effect of hypothermia on renin- angiotensin-aldosterone axis was explored.
Ten male wistar albino rats (mean age 5 months) were anesthetized by intraperitoneal injection of chloralhydrat (0.5 m1/100gr body weight). Then animals were placed in hypothermia apparatus . Their body temperature were reduced to 250 C. AngiotensinI(ANGI) and aldosterone (ALD) levels of serum were measured by radioimmunoassay before and after hypothermia
induction and once every 24 hours for three days. Plasma renin activity (PRA) was also measured by using the standard formula of angiotensin determinates at two temperatures of 40C and 370C .
The results showed that PRA,ANGI and ALD increased significantly immedietly after hypothermia (p<0.03). Later changes were followed as these factors decreased to basal level, except in the case of aldosterone which maintained its increased level significantly for 24 hours (p<0.05).
It seems that moderate hypothermia have stimulatory effect on PRA,ANGI and ALD that results of this study confirm it. |
| first_indexed | 2024-12-21T04:43:45Z |
| format | Article |
| id | doaj.art-f0a126f097fd41548b6c264478078506 |
| institution | Directory Open Access Journal |
| issn | 2588-722X 2588-7238 |
| language | fas |
| last_indexed | 2024-12-21T04:43:45Z |
| publishDate | 2004-06-01 |
| publisher | Hamadan University of Medical Sciences |
| record_format | Article |
| series | پزشکی بالینی ابن سینا |
| spelling | doaj.art-f0a126f097fd41548b6c2644780785062022-12-21T19:15:37ZfasHamadan University of Medical Sciencesپزشکی بالینی ابن سینا2588-722X2588-72382004-06-0111159The Effect of Moderate Hypothermia on Renin-Angiotensin – Aldosterone System in Male RatsMasoumeh Kourosh Arami0Saeed Khameneh1Nosratollah Zarghami2 Hypothermia in nature occurs in hibernating animals. It has applications in medicine in open heart surgery,organ and connective tissue preserving, altitude medicine and geriatrics. Despite the vastness of studies on hypothermia many of its biologic and physiologic effects including endocrine system alterations are still poorly recognized. In this study the effect of hypothermia on renin- angiotensin-aldosterone axis was explored. Ten male wistar albino rats (mean age 5 months) were anesthetized by intraperitoneal injection of chloralhydrat (0.5 m1/100gr body weight). Then animals were placed in hypothermia apparatus . Their body temperature were reduced to 250 C. AngiotensinI(ANGI) and aldosterone (ALD) levels of serum were measured by radioimmunoassay before and after hypothermia induction and once every 24 hours for three days. Plasma renin activity (PRA) was also measured by using the standard formula of angiotensin determinates at two temperatures of 40C and 370C . The results showed that PRA,ANGI and ALD increased significantly immedietly after hypothermia (p<0.03). Later changes were followed as these factors decreased to basal level, except in the case of aldosterone which maintained its increased level significantly for 24 hours (p<0.05). It seems that moderate hypothermia have stimulatory effect on PRA,ANGI and ALD that results of this study confirm it.http://sjh.umsha.ac.ir/article-1-625-en.htmlhypothermiaratsrenin-angiotensin system |
| spellingShingle | Masoumeh Kourosh Arami Saeed Khameneh Nosratollah Zarghami The Effect of Moderate Hypothermia on Renin-Angiotensin – Aldosterone System in Male Rats پزشکی بالینی ابن سینا hypothermia rats renin-angiotensin system |
| title | The Effect of Moderate Hypothermia on Renin-Angiotensin – Aldosterone System in Male Rats |
| title_full | The Effect of Moderate Hypothermia on Renin-Angiotensin – Aldosterone System in Male Rats |
| title_fullStr | The Effect of Moderate Hypothermia on Renin-Angiotensin – Aldosterone System in Male Rats |
| title_full_unstemmed | The Effect of Moderate Hypothermia on Renin-Angiotensin – Aldosterone System in Male Rats |
| title_short | The Effect of Moderate Hypothermia on Renin-Angiotensin – Aldosterone System in Male Rats |
| title_sort | effect of moderate hypothermia on renin angiotensin aldosterone system in male rats |
| topic | hypothermia rats renin-angiotensin system |
| url | http://sjh.umsha.ac.ir/article-1-625-en.html |
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