Urolithin A Attenuates Hyperuricemic Nephropathy in Fructose-Fed Mice by Impairing STING-NLRP3 Axis-Mediated Inflammatory Response via Restoration of Parkin-Dependent Mitophagy

Urolithin A Attenuates Hyperuricemic Nephropathy in Fructose-Fed Mice by Impairing STING-NLRP3 Axis-Mediated Inflammatory Response via Restoration of Parkin-Dependent Mitophagy

Urolithin A (UroA) is one of the primary intestinal metabolites of ellagitannins, showing translational potential as a nutritional intervention in humans. Mounting evidence suggests that fructose consumption contributes to the progression of chronic kidney disease (CKD) that manifests in hyperuricem...

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Bibliographic Details
Main Authors: Cong Zhang, Yingying Song, Liang Chen, Peng Chen, Ming Yuan, Yan Meng, Qi Wang, Guohua Zheng, Zhenpeng Qiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
urolithin A
hyperuricemic nephropathy
mitophagy
STING
NLRP3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.907209/full

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