HDL modification by secretory phospholipase A2 promotes scavenger receptor class B type I interaction and accelerates HDL catabolism

HDL modification by secretory phospholipase A2 promotes scavenger receptor class B type I interaction and accelerates HDL catabolism

During inflammatory states plasma levels of high density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I) are reduced. Secretory group IIa phospholipase A2 (sPLA2) is a cytokine-induced acute-phase enzyme associated with HDL. Transgenic mice overexpressing sPLA2 have reduced HDL levels....

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Bibliographic Details
Main Authors: Frederick C. de Beer, Patrice M. Connell, J. Yu, Maria C. de Beer, Nancy R. Webb, Deneys R. van der Westhuyzen
Format: Article
Language:English
Published: Elsevier 2000-11-01
Series:Journal of Lipid Research
Subjects:
high density lipoprotein
SR-BI
selective cholesteryl ester uptake
adenoviral vector
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520319799

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