Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in individuals without obesity. Here, gut microbiome analysis using a biopsy-proven NAFLD cohort reveal distinct signatures of microbiome-metabolites associated with significant fibrosis in patients with NAFLD without...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18754-5 |
| _version_ | 1818345318867009536 |
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| author | Giljae Lee Hyun Ju You Jasmohan S. Bajaj Sae Kyung Joo Junsun Yu Seoyeon Park Hyena Kang Jeong Hwan Park Jung Ho Kim Dong Hyeon Lee Seonhwa Lee Won Kim GwangPyo Ko |
| author_facet | Giljae Lee Hyun Ju You Jasmohan S. Bajaj Sae Kyung Joo Junsun Yu Seoyeon Park Hyena Kang Jeong Hwan Park Jung Ho Kim Dong Hyeon Lee Seonhwa Lee Won Kim GwangPyo Ko |
| author_sort | Giljae Lee |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in individuals without obesity. Here, gut microbiome analysis using a biopsy-proven NAFLD cohort reveal distinct signatures of microbiome-metabolites associated with significant fibrosis in patients with NAFLD without obesity. |
| first_indexed | 2024-12-13T17:00:28Z |
| format | Article |
| id | doaj.art-f0a332ee4e09467eb4716ab3b8b926a7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T17:00:28Z |
| publishDate | 2020-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f0a332ee4e09467eb4716ab3b8b926a72022-12-21T23:37:49ZengNature PortfolioNature Communications2041-17232020-10-0111111310.1038/s41467-020-18754-5Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLDGiljae Lee0Hyun Ju You1Jasmohan S. Bajaj2Sae Kyung Joo3Junsun Yu4Seoyeon Park5Hyena Kang6Jeong Hwan Park7Jung Ho Kim8Dong Hyeon Lee9Seonhwa Lee10Won Kim11GwangPyo Ko12Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National UniversityDepartment of Environmental Health Sciences, Graduate School of Public Health, Seoul National UniversityDivision of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical CenterDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical CenterDepartment of Environmental Health Sciences, Graduate School of Public Health, Seoul National UniversityDepartment of Environmental Health Sciences, Graduate School of Public Health, Seoul National UniversityDepartment of Environmental Health Sciences, Graduate School of Public Health, Seoul National UniversityDepartment of Pathology, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical CenterDepartment of Pathology, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical CenterDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical CenterDepartment of Bio-convergence Engineering, Korea UniversityDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical CenterDepartment of Environmental Health Sciences, Graduate School of Public Health, Seoul National UniversityNonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in individuals without obesity. Here, gut microbiome analysis using a biopsy-proven NAFLD cohort reveal distinct signatures of microbiome-metabolites associated with significant fibrosis in patients with NAFLD without obesity.https://doi.org/10.1038/s41467-020-18754-5 |
| spellingShingle | Giljae Lee Hyun Ju You Jasmohan S. Bajaj Sae Kyung Joo Junsun Yu Seoyeon Park Hyena Kang Jeong Hwan Park Jung Ho Kim Dong Hyeon Lee Seonhwa Lee Won Kim GwangPyo Ko Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD Nature Communications |
| title | Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD |
| title_full | Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD |
| title_fullStr | Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD |
| title_full_unstemmed | Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD |
| title_short | Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD |
| title_sort | distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non obese nafld |
| url | https://doi.org/10.1038/s41467-020-18754-5 |
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