Gamma-Aminobutyric Acid Increases Erythropoietin by Activation of Citrate Cycle and Stimulation of Hypoxia-Inducible Factors Expression in Rats

Gamma-Aminobutyric Acid Increases Erythropoietin by Activation of Citrate Cycle and Stimulation of Hypoxia-Inducible Factors Expression in Rats

Erythropoietin (EPO) is the primary regulator of erythropoiesis in the mammalian fetus and adult. Deficiency of EPO induces anemia. In this study, we investigated the effect of gamma-aminobutyric acid (GABA) on serum EPO levels and erythropoiesis in rats. Expression levels of <i>Epo</i>-...

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Bibliographic Details
Main Authors: Keun-Tae Park, Jong-Kwon Han, Seong Jin Kim, Young-Hee Lim
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biomolecules
Subjects:
gamma-aminobutyric acid
erythropoietin
erythropoietin receptor
hypoxia-inducible factor
anemia
Online Access:https://www.mdpi.com/2218-273X/10/4/595

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