Feasibility and safety of integrating mass drug administration for helminth control with seasonal malaria chemoprevention among Senegalese children: a randomized controlled, observer-blind trial
Abstract Background The overlap in the epidemiology of malaria and helminths has been identified as a potential area to exploit for the development of an integrated control strategy that may help to achieve elimination of malaria and helminths. A randomized, controlled, observer-blind trial was cond...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12936-023-04784-z |
| _version_ | 1827724518589726720 |
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| author | Muhammed O. Afolabi Doudou Sow Schadrac C. Agbla El Hadji Babacar Fall Fatimata Bintou Sall Amadou Seck Isaac Akhénaton Manga Ibrahima Marietou Mbaye Mor Absa Loum Baba Camara Diatou Niang Babacar Gueye Doudou Sene Ndéye M’backé Kane Boubacar Diop Awa Diouf Ndéye Aida Gaye Marie Pierre Diouf Aminata Colle Lo Brian Greenwood Jean Louis A. Ndiaye |
| author_facet | Muhammed O. Afolabi Doudou Sow Schadrac C. Agbla El Hadji Babacar Fall Fatimata Bintou Sall Amadou Seck Isaac Akhénaton Manga Ibrahima Marietou Mbaye Mor Absa Loum Baba Camara Diatou Niang Babacar Gueye Doudou Sene Ndéye M’backé Kane Boubacar Diop Awa Diouf Ndéye Aida Gaye Marie Pierre Diouf Aminata Colle Lo Brian Greenwood Jean Louis A. Ndiaye |
| author_sort | Muhammed O. Afolabi |
| collection | DOAJ |
| description | Abstract Background The overlap in the epidemiology of malaria and helminths has been identified as a potential area to exploit for the development of an integrated control strategy that may help to achieve elimination of malaria and helminths. A randomized, controlled, observer-blind trial was conducted to assess the feasibility and safety of combining mass drug administration (MDA) for schistosomiasis and soil transmitted helminths (STH) with seasonal malaria chemoprevention (SMC) among children living in Senegal. Methods Female and male children aged 1–14 years were randomized 1:1:1, to receive Vitamin A and Zinc on Day 0, followed by SMC drugs (sulfadoxine-pyrimethamine and amodiaquine) on Days 1–3 (control group); or praziquantel and Vitamin A on Day 0, followed by SMC drugs on Days 1–3 (treatment group 1); or albendazole and praziquantel on Day 0, followed by SMC drugs on Days 1–3 (treatment group 2). Safety assessment was performed by collecting adverse events from all children for six subsequent days following administration of the study drugs. Pre- and post-intervention, blood samples were collected for determination of haemoglobin concentration, malaria microscopy, and PCR assays. Stool samples were analyzed using Kato-Katz, Merthiolate-iodine-formalin and PCR methods. Urine filtration, PCR and circulating cathodic antigen tests were also performed. Results From 9 to 22 June 2022, 627 children aged 1–14 years were randomized into the three groups described above. Mild, transient vomiting was observed in 12.6% (26/206) of children in treatment group 2, in 10.6% (22/207) in group 1, and in 4.2% (9/214) in the control group (p = 0.005). Pre-intervention, the geometric mean value of Plasmodium falciparum parasite density was highest among children who received albendazole, praziquantel with SMC drugs. Post-intervention, the parasite density was highest among children who received SMC drugs only. Children who received praziquantel and SMC drugs had a lower risk of developing severe anaemia than their counterparts who received SMC drugs alone (OR = 0.81, 95% CI 0.13–5.00, p = 0.63). Conclusions Integration of MDA for helminths with SMC drugs was safe and feasible among Senegalese children. These findings support further evaluation of the integrated control model. Trial registration: The study is registered at Clinical Trial.gov NCT05354258. |
| first_indexed | 2024-03-10T22:16:53Z |
| format | Article |
| id | doaj.art-f0a5b2606b444acbba75951d501e08ac |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-03-10T22:16:53Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-f0a5b2606b444acbba75951d501e08ac2023-11-19T12:26:32ZengBMCMalaria Journal1475-28752023-11-0122111510.1186/s12936-023-04784-zFeasibility and safety of integrating mass drug administration for helminth control with seasonal malaria chemoprevention among Senegalese children: a randomized controlled, observer-blind trialMuhammed O. Afolabi0Doudou Sow1Schadrac C. Agbla2El Hadji Babacar Fall3Fatimata Bintou Sall4Amadou Seck5Isaac Akhénaton Manga6Ibrahima Marietou Mbaye7Mor Absa Loum8Baba Camara9Diatou Niang10Babacar Gueye11Doudou Sene12Ndéye M’backé Kane13Boubacar Diop14Awa Diouf15Ndéye Aida Gaye16Marie Pierre Diouf17Aminata Colle Lo18Brian Greenwood19Jean Louis A. Ndiaye20London School of Hygiene & Tropical MedicineUniversité Gaston Berger de Saint-LouisLondon School of Hygiene & Tropical MedicineUniversité de ThiesUniversité de ThiesUniversité de ThiesUniversité Cheikh Anta DiopUniversité de ThiesUniversité de ThiesSaraya Health CentreSaraya Health CentreMinistry of Health and Social ActionMinistry of Health and Social ActionMinistry of Health and Social ActionMinistry of Health and Social ActionUniversité de ThiesUniversité de ThiesUniversité de ThiesUniversité Cheikh Anta DiopLondon School of Hygiene & Tropical MedicineUniversité de ThiesAbstract Background The overlap in the epidemiology of malaria and helminths has been identified as a potential area to exploit for the development of an integrated control strategy that may help to achieve elimination of malaria and helminths. A randomized, controlled, observer-blind trial was conducted to assess the feasibility and safety of combining mass drug administration (MDA) for schistosomiasis and soil transmitted helminths (STH) with seasonal malaria chemoprevention (SMC) among children living in Senegal. Methods Female and male children aged 1–14 years were randomized 1:1:1, to receive Vitamin A and Zinc on Day 0, followed by SMC drugs (sulfadoxine-pyrimethamine and amodiaquine) on Days 1–3 (control group); or praziquantel and Vitamin A on Day 0, followed by SMC drugs on Days 1–3 (treatment group 1); or albendazole and praziquantel on Day 0, followed by SMC drugs on Days 1–3 (treatment group 2). Safety assessment was performed by collecting adverse events from all children for six subsequent days following administration of the study drugs. Pre- and post-intervention, blood samples were collected for determination of haemoglobin concentration, malaria microscopy, and PCR assays. Stool samples were analyzed using Kato-Katz, Merthiolate-iodine-formalin and PCR methods. Urine filtration, PCR and circulating cathodic antigen tests were also performed. Results From 9 to 22 June 2022, 627 children aged 1–14 years were randomized into the three groups described above. Mild, transient vomiting was observed in 12.6% (26/206) of children in treatment group 2, in 10.6% (22/207) in group 1, and in 4.2% (9/214) in the control group (p = 0.005). Pre-intervention, the geometric mean value of Plasmodium falciparum parasite density was highest among children who received albendazole, praziquantel with SMC drugs. Post-intervention, the parasite density was highest among children who received SMC drugs only. Children who received praziquantel and SMC drugs had a lower risk of developing severe anaemia than their counterparts who received SMC drugs alone (OR = 0.81, 95% CI 0.13–5.00, p = 0.63). Conclusions Integration of MDA for helminths with SMC drugs was safe and feasible among Senegalese children. These findings support further evaluation of the integrated control model. Trial registration: The study is registered at Clinical Trial.gov NCT05354258.https://doi.org/10.1186/s12936-023-04784-zFalciparum malariaSoil-transmitted helminthiasisSchistosomiasisCo-infectionIntegrated control strategy |
| spellingShingle | Muhammed O. Afolabi Doudou Sow Schadrac C. Agbla El Hadji Babacar Fall Fatimata Bintou Sall Amadou Seck Isaac Akhénaton Manga Ibrahima Marietou Mbaye Mor Absa Loum Baba Camara Diatou Niang Babacar Gueye Doudou Sene Ndéye M’backé Kane Boubacar Diop Awa Diouf Ndéye Aida Gaye Marie Pierre Diouf Aminata Colle Lo Brian Greenwood Jean Louis A. Ndiaye Feasibility and safety of integrating mass drug administration for helminth control with seasonal malaria chemoprevention among Senegalese children: a randomized controlled, observer-blind trial Malaria Journal Falciparum malaria Soil-transmitted helminthiasis Schistosomiasis Co-infection Integrated control strategy |
| title | Feasibility and safety of integrating mass drug administration for helminth control with seasonal malaria chemoprevention among Senegalese children: a randomized controlled, observer-blind trial |
| title_full | Feasibility and safety of integrating mass drug administration for helminth control with seasonal malaria chemoprevention among Senegalese children: a randomized controlled, observer-blind trial |
| title_fullStr | Feasibility and safety of integrating mass drug administration for helminth control with seasonal malaria chemoprevention among Senegalese children: a randomized controlled, observer-blind trial |
| title_full_unstemmed | Feasibility and safety of integrating mass drug administration for helminth control with seasonal malaria chemoprevention among Senegalese children: a randomized controlled, observer-blind trial |
| title_short | Feasibility and safety of integrating mass drug administration for helminth control with seasonal malaria chemoprevention among Senegalese children: a randomized controlled, observer-blind trial |
| title_sort | feasibility and safety of integrating mass drug administration for helminth control with seasonal malaria chemoprevention among senegalese children a randomized controlled observer blind trial |
| topic | Falciparum malaria Soil-transmitted helminthiasis Schistosomiasis Co-infection Integrated control strategy |
| url | https://doi.org/10.1186/s12936-023-04784-z |
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