Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies
Pretomanid has been approved for use in cases of multi-drug resistant pulmonary tuberculosis, yet the penetration of this antibiotic into other target tissues is not well established. Authors provide insight on pretomanid pharmacokinetics in the central nervous system, using positron emission tomogr...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35730-3 |
| _version_ | 1828083304933359616 |
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| author | Filipa Mota Camilo A. Ruiz-Bedoya Elizabeth W. Tucker Daniel P. Holt Patricia De Jesus Martin A. Lodge Clara Erice Xueyi Chen Melissa Bahr Kelly Flavahan John Kim Mary Katherine Brosnan Alvaro A. Ordonez Charles A. Peloquin Robert F. Dannals Sanjay K. Jain |
| author_facet | Filipa Mota Camilo A. Ruiz-Bedoya Elizabeth W. Tucker Daniel P. Holt Patricia De Jesus Martin A. Lodge Clara Erice Xueyi Chen Melissa Bahr Kelly Flavahan John Kim Mary Katherine Brosnan Alvaro A. Ordonez Charles A. Peloquin Robert F. Dannals Sanjay K. Jain |
| author_sort | Filipa Mota |
| collection | DOAJ |
| description | Pretomanid has been approved for use in cases of multi-drug resistant pulmonary tuberculosis, yet the penetration of this antibiotic into other target tissues is not well established. Authors provide insight on pretomanid pharmacokinetics in the central nervous system, using positron emission tomography in animal models, and human studies. |
| first_indexed | 2024-04-11T04:06:54Z |
| format | Article |
| id | doaj.art-f0a782321c4e4e36aa37ab969660b2e2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T04:06:54Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f0a782321c4e4e36aa37ab969660b2e22023-01-01T12:22:37ZengNature PortfolioNature Communications2041-17232022-12-011311910.1038/s41467-022-35730-3Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studiesFilipa Mota0Camilo A. Ruiz-Bedoya1Elizabeth W. Tucker2Daniel P. Holt3Patricia De Jesus4Martin A. Lodge5Clara Erice6Xueyi Chen7Melissa Bahr8Kelly Flavahan9John Kim10Mary Katherine Brosnan11Alvaro A. Ordonez12Charles A. Peloquin13Robert F. Dannals14Sanjay K. Jain15Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of MedicineCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of MedicineCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of MedicineRussell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of MedicineCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of MedicineRussell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of MedicineCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of MedicineCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of MedicineCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of MedicineCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of MedicineCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of MedicineRussell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of MedicineCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of MedicineInfectious Disease Pharmacokinetics Laboratory, Pharmacotherapy and Translational Research, University of Florida College of PharmacyRussell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of MedicineCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of MedicinePretomanid has been approved for use in cases of multi-drug resistant pulmonary tuberculosis, yet the penetration of this antibiotic into other target tissues is not well established. Authors provide insight on pretomanid pharmacokinetics in the central nervous system, using positron emission tomography in animal models, and human studies.https://doi.org/10.1038/s41467-022-35730-3 |
| spellingShingle | Filipa Mota Camilo A. Ruiz-Bedoya Elizabeth W. Tucker Daniel P. Holt Patricia De Jesus Martin A. Lodge Clara Erice Xueyi Chen Melissa Bahr Kelly Flavahan John Kim Mary Katherine Brosnan Alvaro A. Ordonez Charles A. Peloquin Robert F. Dannals Sanjay K. Jain Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies Nature Communications |
| title | Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies |
| title_full | Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies |
| title_fullStr | Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies |
| title_full_unstemmed | Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies |
| title_short | Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies |
| title_sort | dynamic 18f pretomanid pet imaging in animal models of tb meningitis and human studies |
| url | https://doi.org/10.1038/s41467-022-35730-3 |
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