Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with non-metastatic and metastatic prostate cancer: A meta-analysis and systematic review
Objective: To analyze data available in the literature regarding a possible prognostic value of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in prostate cancer (PCa) patients stratified in non-metastatic and metastatic diseases. Methods: A literature search process...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-04-01
|
| Series: | Asian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388223000218 |
| _version_ | 1797198822143688704 |
|---|---|
| author | Stefano Salciccia Marco Frisenda Giulio Bevilacqua Pietro Viscuso Paolo Casale Ettore De Berardinis Giovanni Battista Di Pierro Susanna Cattarino Gloria Giorgino Davide Rosati Francesco Del Giudice Alessandro Sciarra Gianna Mariotti Alessandro Gentilucci |
| author_facet | Stefano Salciccia Marco Frisenda Giulio Bevilacqua Pietro Viscuso Paolo Casale Ettore De Berardinis Giovanni Battista Di Pierro Susanna Cattarino Gloria Giorgino Davide Rosati Francesco Del Giudice Alessandro Sciarra Gianna Mariotti Alessandro Gentilucci |
| author_sort | Stefano Salciccia |
| collection | DOAJ |
| description | Objective: To analyze data available in the literature regarding a possible prognostic value of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in prostate cancer (PCa) patients stratified in non-metastatic and metastatic diseases. Methods: A literature search process was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. In our meta-analysis, the pooled event rate estimated and the pooled hazard ratio were calculated using a random effect model. Results: Forty-two articles were selected for our analysis. The pooled risk difference for non-organ confined PCa between high and low NLR cases was 0.06 (95% confidence interval [CI]: −0.03–0.15) and between high and low PLR cases increased to 0.30 (95% CI: 0.16–0.43). In non-metastatic PCa cases, the pooled hazard ratio for overall mortality between high and low NLR was 1.33 (95% CI: 0.78–1.88) and between high and low PLR was 1.47 (95% CI: 0.91–2.03), whereas in metastatic PCa cases, between high and low NLR was 1.79 (95% CI: 1.44–2.13) and between high and low PLR was 1.05 (95% CI: 0.87–1.24). Conclusion: The prognostic values of NLR and PLR in terms of PCa characteristics and responses after treatment show a high level of heterogeneity of results among studies. These two ratios can represent the inflammatory and immunity status of the patient related to several conditions. A higher predictive value is related to a high NLR in terms of risk for overall mortality in metastatic PCa cases under systemic treatments. |
| first_indexed | 2024-04-24T07:05:58Z |
| format | Article |
| id | doaj.art-f0a7c9b7969442d18423587643e0dd15 |
| institution | Directory Open Access Journal |
| issn | 2214-3882 |
| language | English |
| last_indexed | 2024-04-24T07:05:58Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj.art-f0a7c9b7969442d18423587643e0dd152024-04-22T04:11:41ZengElsevierAsian Journal of Urology2214-38822024-04-01112191207Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with non-metastatic and metastatic prostate cancer: A meta-analysis and systematic reviewStefano Salciccia0Marco Frisenda1Giulio Bevilacqua2Pietro Viscuso3Paolo Casale4Ettore De Berardinis5Giovanni Battista Di Pierro6Susanna Cattarino7Gloria Giorgino8Davide Rosati9Francesco Del Giudice10Alessandro Sciarra11Gianna Mariotti12Alessandro Gentilucci13Department of Urology, Sapienza Rome University, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, 00161 Rome, Italy; Corresponding author.Department of Urology, Sapienza Rome University, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Urology, Humanitas, 20089 Rozzano, MI, ItalyDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Urology, Sapienza Rome University, Policlinico Umberto I, 00161 Rome, ItalyObjective: To analyze data available in the literature regarding a possible prognostic value of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in prostate cancer (PCa) patients stratified in non-metastatic and metastatic diseases. Methods: A literature search process was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. In our meta-analysis, the pooled event rate estimated and the pooled hazard ratio were calculated using a random effect model. Results: Forty-two articles were selected for our analysis. The pooled risk difference for non-organ confined PCa between high and low NLR cases was 0.06 (95% confidence interval [CI]: −0.03–0.15) and between high and low PLR cases increased to 0.30 (95% CI: 0.16–0.43). In non-metastatic PCa cases, the pooled hazard ratio for overall mortality between high and low NLR was 1.33 (95% CI: 0.78–1.88) and between high and low PLR was 1.47 (95% CI: 0.91–2.03), whereas in metastatic PCa cases, between high and low NLR was 1.79 (95% CI: 1.44–2.13) and between high and low PLR was 1.05 (95% CI: 0.87–1.24). Conclusion: The prognostic values of NLR and PLR in terms of PCa characteristics and responses after treatment show a high level of heterogeneity of results among studies. These two ratios can represent the inflammatory and immunity status of the patient related to several conditions. A higher predictive value is related to a high NLR in terms of risk for overall mortality in metastatic PCa cases under systemic treatments.http://www.sciencedirect.com/science/article/pii/S2214388223000218Prostatic neoplasmNeutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratioMeta-analysisRadical prostatectomyMetastatic |
| spellingShingle | Stefano Salciccia Marco Frisenda Giulio Bevilacqua Pietro Viscuso Paolo Casale Ettore De Berardinis Giovanni Battista Di Pierro Susanna Cattarino Gloria Giorgino Davide Rosati Francesco Del Giudice Alessandro Sciarra Gianna Mariotti Alessandro Gentilucci Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with non-metastatic and metastatic prostate cancer: A meta-analysis and systematic review Asian Journal of Urology Prostatic neoplasm Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Meta-analysis Radical prostatectomy Metastatic |
| title | Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with non-metastatic and metastatic prostate cancer: A meta-analysis and systematic review |
| title_full | Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with non-metastatic and metastatic prostate cancer: A meta-analysis and systematic review |
| title_fullStr | Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with non-metastatic and metastatic prostate cancer: A meta-analysis and systematic review |
| title_full_unstemmed | Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with non-metastatic and metastatic prostate cancer: A meta-analysis and systematic review |
| title_short | Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with non-metastatic and metastatic prostate cancer: A meta-analysis and systematic review |
| title_sort | prognostic role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in patients with non metastatic and metastatic prostate cancer a meta analysis and systematic review |
| topic | Prostatic neoplasm Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Meta-analysis Radical prostatectomy Metastatic |
| url | http://www.sciencedirect.com/science/article/pii/S2214388223000218 |
| work_keys_str_mv | AT stefanosalciccia prognosticroleofplatelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnonmetastaticandmetastaticprostatecancerametaanalysisandsystematicreview AT marcofrisenda prognosticroleofplatelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnonmetastaticandmetastaticprostatecancerametaanalysisandsystematicreview AT giuliobevilacqua prognosticroleofplatelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnonmetastaticandmetastaticprostatecancerametaanalysisandsystematicreview AT pietroviscuso prognosticroleofplatelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnonmetastaticandmetastaticprostatecancerametaanalysisandsystematicreview AT paolocasale prognosticroleofplatelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnonmetastaticandmetastaticprostatecancerametaanalysisandsystematicreview AT ettoredeberardinis prognosticroleofplatelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnonmetastaticandmetastaticprostatecancerametaanalysisandsystematicreview AT giovannibattistadipierro prognosticroleofplatelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnonmetastaticandmetastaticprostatecancerametaanalysisandsystematicreview AT susannacattarino prognosticroleofplatelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnonmetastaticandmetastaticprostatecancerametaanalysisandsystematicreview AT gloriagiorgino prognosticroleofplatelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnonmetastaticandmetastaticprostatecancerametaanalysisandsystematicreview AT daviderosati prognosticroleofplatelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnonmetastaticandmetastaticprostatecancerametaanalysisandsystematicreview AT francescodelgiudice prognosticroleofplatelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnonmetastaticandmetastaticprostatecancerametaanalysisandsystematicreview AT alessandrosciarra prognosticroleofplatelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnonmetastaticandmetastaticprostatecancerametaanalysisandsystematicreview AT giannamariotti prognosticroleofplatelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnonmetastaticandmetastaticprostatecancerametaanalysisandsystematicreview AT alessandrogentilucci prognosticroleofplatelettolymphocyteratioandneutrophiltolymphocyteratioinpatientswithnonmetastaticandmetastaticprostatecancerametaanalysisandsystematicreview |