Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms
Retinal degenerative diseases are the major factors leading to severe visual impairment and even irreversible blindness worldwide. The therapeutic approach for retinal degenerative diseases is one extremely urgent and hot spot in science research. The sigma-1 receptor is a novel, multifunctional lig...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/14/7572 |
| _version_ | 1797446663039614976 |
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| author | Zifen Xu Yushuang Lei Huan Qin Shiyao Zhang Ping Li Kai Yao |
| author_facet | Zifen Xu Yushuang Lei Huan Qin Shiyao Zhang Ping Li Kai Yao |
| author_sort | Zifen Xu |
| collection | DOAJ |
| description | Retinal degenerative diseases are the major factors leading to severe visual impairment and even irreversible blindness worldwide. The therapeutic approach for retinal degenerative diseases is one extremely urgent and hot spot in science research. The sigma-1 receptor is a novel, multifunctional ligand-mediated molecular chaperone residing in endoplasmic reticulum (ER) membranes and the ER-associated mitochondrial membrane (ER-MAM); it is widely distributed in numerous organs and tissues of various species, providing protective effects on a variety of degenerative diseases. Over three decades, considerable research has manifested the neuroprotective function of sigma-1 receptor in the retina and has attempted to explore the molecular mechanism of action. In the present review, we will discuss neuroprotective effects of the sigma-1 receptor in retinal degenerative diseases, mainly in aspects of the following: the localization in different types of retinal neurons, the interactions of sigma-1 receptors with other molecules, the correlated signaling pathways, the influence of sigma-1 receptors to cellular functions, and the potential therapeutic effects on retinal degenerative diseases. |
| first_indexed | 2024-03-09T13:43:48Z |
| format | Article |
| id | doaj.art-f0a8dd6a11c843dd804412d9531c90be |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T13:43:48Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f0a8dd6a11c843dd804412d9531c90be2023-11-30T21:03:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012314757210.3390/ijms23147572Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential MechanismsZifen Xu0Yushuang Lei1Huan Qin2Shiyao Zhang3Ping Li4Kai Yao5Institute of Visual Neuroscience and Stem Cell Engineering, College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan 430065, ChinaInstitute of Visual Neuroscience and Stem Cell Engineering, College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan 430065, ChinaInstitute of Visual Neuroscience and Stem Cell Engineering, College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan 430065, ChinaInstitute of Visual Neuroscience and Stem Cell Engineering, College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan 430065, ChinaInstitute of Visual Neuroscience and Stem Cell Engineering, College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan 430065, ChinaInstitute of Visual Neuroscience and Stem Cell Engineering, College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan 430065, ChinaRetinal degenerative diseases are the major factors leading to severe visual impairment and even irreversible blindness worldwide. The therapeutic approach for retinal degenerative diseases is one extremely urgent and hot spot in science research. The sigma-1 receptor is a novel, multifunctional ligand-mediated molecular chaperone residing in endoplasmic reticulum (ER) membranes and the ER-associated mitochondrial membrane (ER-MAM); it is widely distributed in numerous organs and tissues of various species, providing protective effects on a variety of degenerative diseases. Over three decades, considerable research has manifested the neuroprotective function of sigma-1 receptor in the retina and has attempted to explore the molecular mechanism of action. In the present review, we will discuss neuroprotective effects of the sigma-1 receptor in retinal degenerative diseases, mainly in aspects of the following: the localization in different types of retinal neurons, the interactions of sigma-1 receptors with other molecules, the correlated signaling pathways, the influence of sigma-1 receptors to cellular functions, and the potential therapeutic effects on retinal degenerative diseases.https://www.mdpi.com/1422-0067/23/14/7572sigma-1 receptordegenerative retinal diseasesneuroprotectionNrf2 signaling pathwayMAPK signaling pathway |
| spellingShingle | Zifen Xu Yushuang Lei Huan Qin Shiyao Zhang Ping Li Kai Yao Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms International Journal of Molecular Sciences sigma-1 receptor degenerative retinal diseases neuroprotection Nrf2 signaling pathway MAPK signaling pathway |
| title | Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms |
| title_full | Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms |
| title_fullStr | Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms |
| title_full_unstemmed | Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms |
| title_short | Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms |
| title_sort | sigma 1 receptor in retina neuroprotective effects and potential mechanisms |
| topic | sigma-1 receptor degenerative retinal diseases neuroprotection Nrf2 signaling pathway MAPK signaling pathway |
| url | https://www.mdpi.com/1422-0067/23/14/7572 |
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